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<p>Contributors xi</p> <p>Editors’ Note xxi</p> <p>Acknowledgments xxii</p> <p><b>Section I Veterinary Practice 1</b></p> <p>1 Herd Evaluation 3<br /> Records, benchmarks, four circles approach, diagnostic approaches, prioritizing interventions, reporting, blood sample collection, oral fluid collection.</p> <p>2 Behavior and Welfare 17<br /> Definitions of welfare, normal vs. abnormal behaviors, maternal behaviors, minimizing welfare impact of invasiveprocedures, feeding and drinking behaviors, human interactions, behavior responses due to disease, recognizing pain, vices, objective measures of pain.</p> <p>3 Genetics and Health 42<br /> Genetic influences on mortality, disease resistance, immune response and sow productive lifetime, with a summary of recent genetic advances.</p> <p>4 Effect of Environment on Health 50<br /> Evaluation of the environment, recommended air temperatures, minimum ventilation rates, space recommendations, water requirements, feeder space recommendations. Investigation of death due to ventilation failure.Impact of noise levels and stray voltage.</p> <p>5 Differential Diagnosis of Diseases 59<br /> Diarrhea, vomiting, rectal prolapses, respiratory distress, anemia, sneezing, skin, neurologic, lameness, reproductive, congenital, zoonotic, vesicular lesions, urinary tract.</p> <p>6 Diagnostic Tests, Test Performance, and Considerations for Interpretation 75<br /> How diagnostic tests are performed, advantages, and disadvantages. PCR testing considerations including quantitative interpretation. Appropriate uses of genetic sequencing. Descriptions of metagenomics technology.</p> <p>7 Optimizing Sample Selection, Collection, and Submission to Optimize Diagnostic Value 98<br /> Developing the diagnostic plan, diagnostic sample selection, pig necropsy, necropsy safety, knife sharpening.</p> <p>8 Collecting Evidence and Establishing Causality 112<br /> Sources of variation in test results, sensitivity and specificity, testing in series or parallel, selecting test cutoff values, selecting appropriate sample size, screening and confirmatory tests. Evidence-based medicine, establishing baselines, evaluating interventions.</p> <p>9 Disease Control, Prevention, and Elimination 123<br /> Routes of transmission, ecology of disease, pathogen cycles, biological risk management, principles of biosecurity, biocontainment, bioexclusion.</p> <p>10 Drug Pharmacology, Therapy, and Prophylaxis 158<br /> Antimicrobial drug classes, considerations for treatment, residue avoidance, establishing treatment regimens, limiting the development of resistance, parasiticides, impact of drug treatment on immunity, bacteriophages, probiotics, hormones, anti-inflammatory drugs.</p> <p>11 Anesthesia and Surgical Procedures in Swine 171<br /> Injectable anesthetic agents, sedation, catheterization techniques, epidural injection, anesthetic drug combinations, reversal agents and pain management. Surgical procedures including castration, correction of prolapses, cystostomy procedures, cesarean section, fracture repair, tusk removal, abdominal and musculoskeletal procedures.</p> <p>12 Preharvest Food Safety, Zoonotic Diseases, and the Human Health Interface 197<br /> Physical, chemical, and biologic hazards, drug residues, MRSA, feed safety, certification programs.</p> <p>13 Special Considerations for Show and Pet Pigs 211<br /> Dynamics of the show pig industry, biosecurity, zoonotic implications, vaccination protocols, behavior and training, ethics, teeth trimming, hoof trimming, obesity, and parasites.</p> <p><b>Section II Body Systems 221</b></p> <p>14 Cardiovascular and Hematopoietic Systems 223<br /> Anatomy, pathophysiology, mulberry heart disease, anemia, shock, clinical pathology.</p> <p>15 Digestive System 234<br /> Interactions of flora, nutrition, immune system, anatomy, pathophysiology, gastric ulcers, hemorrhagic bowel syndrome, prolapses, hernias.</p> <p>16 Immune System 264<br /> Innate and adaptive immunity. Cellular, humoral, mucosal and passive immune mechanisms. Stress, nutrition, immunosuppression, vaccination. Lactogenic immunity.</p> <p>17 Integumentary System: Skin, Hoof, and Claw 292<br /> Pathophysiology of skin, infectious conditions, vesicles, ear necrosis, porcine dermatopathy and nephropathy syndrome. Pathophysiology of coronary band, foot and claw. Traumatic and nutritional contributors to foot and claw lesions.</p> <p>18 Mammary System 313<br /> Structure and development, physiology of lactation, physiology of maternal immunity, pathophysiology of lactation dysfunction, mastitis, dysgalactia, risk factors.</p> <p>19 Nervous and Locomotor System <i>339<br /> </i>Pathophysiology of nervous system, muscle, bone, joint, and eye. Congenital abnormalities, splayleg, congenital tremor, myopathy, porcine stress syndrome, arthritis, metabolic bone disease, rickets, osteochondrosis.</p> <p>20 Diseases of the Reproductive System 373<br /> Control of estrus, pregnancy, and parturition. Pregnancy diagnosis, dystocia, prolapse, discharge, malereproductive function, semen quality. Laboratory investigation of abortion and reproductive failure.</p> <p>21 Respiratory System 393<br /> Anatomy, structure, function, pathophysiology.</p> <p>22 Urinary System 408<br /> Anatomy, structure, function, pathophysiology.</p> <p><b>Section III Viral Diseases 425</b></p> <p>23 Overview of Viruses 427<br /> General characteristics of viruses, virus taxonomy, detection, characterization of viruses.</p> <p>24 Adenoviruses 438</p> <p>25 African Swine Fever Virus 443</p> <p>26 Anelloviruses 453<br /> Torque teno sus viruses.</p> <p>27 Astroviruses 457</p> <p>28 Bunyaviruses 461<br /> Akabane virus, Lumbo virus, Oya virus, Tahyna virus.</p> <p>29 Caliciviruses 464<br /> Porcine noroviruses, porcine sapoviruses, St-Valérien virus, vesicular exanthema of swine virus.</p> <p>30 Circoviruses 473</p> <p>31 Coronaviruses 488<br /> Hemagglutinating encephalomyelitis virus, porcine deltacoronavirus, porcine epidemic diarrhea virus, porcine respiratory coronavirus, porcine torovirus, transmissible gastroenteritis virus.</p> <p>32 Filoviruses 524<br /> Reston ebolavirus, Zaire ebolavirus.</p> <p>33 Flaviviruses 530<br /> Japanese encephalitis virus, Murray Valley encephalitis virus, West Nile virus, other flaviviruses.</p> <p>34 Hepatitis E Virus 544</p> <p>35 Herpesviruses 548<br /> Malignant catarrhal fever (ovine herpesvirus 2), porcine cytomegalovirus, porcine lymphotropic herpesviruses, pseudorabies (Aujeszky’s disease) virus.</p> <p>36 Influenza Viruses 576</p> <p>37 Paramyxoviruses 594<br /> Menangle virus, Nipah virus, porcine parainfluenza virus 1, porcine rubulavirus (blue eye paramyxovirus).</p> <p>38 Parvoviruses 611</p> <p>39 Pestiviruses 622<br /> Atypical porcine pestivirus, border disease virus, bovine viral diarrhea virus, Bungowannah virus, classical swine fever virus.</p> <p>40 Picornaviruses 641<br /> Encephalomyocarditis virus, foot-and-mouth disease virus, porcine enteroviruses, porcine kobuvirus, porcine picornavirus Japan, porcine sapelovirus, porcine teschovirus, Seneca Valley virus, swine pasivirus, swine vesicular disease virus.</p> <p>41 Porcine Reproductive and Respiratory Syndrome Viruses (Porcine Arteriviruses) 685</p> <p>42 Swinepox Virus 709</p> <p>43 Reoviruses (Rotaviruses and Reoviruses) 715</p> <p>44 Retroviruses 728</p> <p>45 Rhabdoviruses 733<br /> Rabies virus, vesicular stomatitis viruses.</p> <p>46 Togaviruses 740<br /> Eastern equine encephalitis virus, Getah virus, Sagiyama virus, Ross River virus.</p> <p><b>Section IV Bacterial Diseases 743</b></p> <p>47 Overview of Bacteria 745<br /> Characteristics of genera, disease mechanisms, table of bacterial diseases. Issues in the development of bacterial disease (normal flora, biofilms, dysbacteriosis).</p> <p>48 Actinobacillosis 749<br /> <i>Actinobacillus pleuropneumoniae </i>– pleuropneumonia; <i>Actinobacillus suis </i>– septicemia, pleuropneumonia; <i>Actinobacillus equuli </i>– septicemia.</p> <p>49 Bordetellosis 767<br /> <i>Bordetella bronchiseptica </i>– nonprogressive atrophic rhinitis, bronchopneumonia.</p> <p>50 Brucellosis 778<br /> <i>Brucella suis </i>– infertility, abortion, perinatal mortality.</p> <p>51 Clostridial Diseases 792<br /> <i>Clostridium perfringens </i>type C – necrohemorrhagic enteritis; <i>Clostridium perfringens </i>type A – enteritis;<i> Clostridium difficile </i>– necrotizing colitis; <i>Clostridium septicum, perfringens </i>type A, <i>novyi, chauvoei </i>– <i>cellulitis </i>and gas gangrene; <i>Clostridium tetani </i>– tetanus; <i>Clostridium botulinum </i>– botulism.</p> <p>52 Colibacillosis 807<br /> Neonatal <i>E. coli </i>diarrhea, post weaning <i>E. coli </i>diarrhea and edema disease, <i>E. coli </i>causing fatal shock, systemic<i> E. coli </i>infections, coliform mastitis, nonspecific urinary tract infection.</p> <p>53 Erysipelas 835<br /> <i>Erysipelothrix rhusiopathiae </i>– <i>septicemia, arthritis</i>, endocarditis; <i>Erysipelothrix tonsillarum </i>– arthritis, endocarditis.</p> <p>54 Glässer’s Disease 844<br /> <i>Haemophilus parasuis </i>– fibrinous polyserositis and arthritis.</p> <p>55 Leptospirosis 854<br /> <i>Leptospira </i>spp. – abortion and stillbirths.</p> <p>56 Mycoplasmosis 863<br /> <i>Mycoplasma hyopneumoniae </i>– enzootic pneumonia; <i>Mycoplasma hyorhinis </i>– polyserositis, arthritis; <i>Mycoplasma hyosynoviae </i>– arthritis; <i>Mycoplasma suis (Eperythrozoon suis) </i>– anemia.</p> <p>57 Pasteurellosis 884<br /> <i>Pasteurella multocida </i>– progressive atrophic rhinitis, pneumonia, septicemia.</p> <p>58 Proliferative Enteropathy 898<br /> <i>Lawsonia intracellularis </i>– acute proliferative hemorrhagic enteropathy (PHE), chronic porcine proliferative enteropathy (PPE).</p> <p>59 Salmonellosis 912<br /> <i>Salmonella typhimurium</i>, <i>typhimurium </i>I 1,4,[5],12:i:-variant, <i>heidelberg, typhisuis </i>– enterocolitis; <i>Salmonella choleraesuis </i>var. <i>kunzendorf </i>– septicemia, enterocolitis; <i>Salmonella dublin, enteriditis </i>– meningitis.</p> <p>60 Staphylococcosis 926<br /> <i>Staphylococcus hyicus </i>– exudative epidermitis; <i>Staphylococcus aureus </i>– skin infections, mastitis, others.</p> <p>61 Streptococcosis <i>934<br /> </i>Streptococcus suis – septicemia, meningitis, others; Streptococcus porcinus – cervical lymphadenitis; <i>Streptococcus dysgalactiae </i>subsp. equisimilis – septicemia, arthritis, others. Other streptococci – various conditions. <i>Enterococcus durans </i>and <i>hirae </i>– diarrhea.</p> <p>62 Swine Dysentery and Brachyspiral Colitis 951<br /> <i>Brachyspira hyodysenteriae, hampsonii, suanatina </i>– swine dysentery; <i>Brachyspira pilosicoli </i>– intestinal (colonic) spirochetosis; <i>Brachyspira intermedia, murdochii </i>– brachyspiral (mild) colitis.</p> <p>63 Tuberculosis 971<br /> <i>Mycobacterium avium </i>subsps. <i>avium </i>and <i>hominissuis</i>, <i>M. bovis, M. caprae, M. tuberculosis </i>– localized alimentary lymphadenitis, rare disseminated tuberculosis.</p> <p>64 Miscellaneous Bacterial Infections 981<br /> <i>Actinobaculum suis (Eubacterium suis) </i>– cystitis, pyelonephritis; <i>Actinomyces hyovaginalis </i>– abortion, lung abscesses; <i>Bacillus anthracis </i>– anthrax; <i>Burkholderia pseudomallei </i>– melioidosis; <i>Campylobacter </i>spp. – enterocolitis; <i>Chlamydia </i>– enteritis, pneumonia, abortion, etc.; <i>Enterococci </i>– neonatal diarrhea; <i>Klebsiella pneumoniae </i>– septicemia; <i>Listeria monocytogenes </i>– septicemia, encephalitis, abortion; <i>Rhodococcus equi </i>– granulomatous lymphadenitis<i>; Treponema pedis </i>– ear necrosis, other skin lesions; <i>Trueperella abortisuis </i>– <i>abortion; Trueperella pyogenes </i>– pyogenic sepsis; <i>Yersinia </i>spp. – enterocolitis.</p> <p><b>Section V Parasitic Diseases 1003</b></p> <p>65 External Parasites 1005<br /> Mange <i>(Sarcoptes, Demodex)</i>, lice, fleas, mosquitoes, flies (myiasis), ticks.</p> <p>66 Coccidia and Other Protozoa 1015<br /> Coccidia <i>(Cystoisospora, Eimeria)</i>, <i>Toxoplasma</i>, <i>Sarcocystis</i>, <i>Cryptosporidium</i>, <i>Giardia</i>, microsporidia <i>(Entercytozoon, Encephalitozoon)</i>, <i>Balantidium coli, Entamoeba.</i></p> <p>67 Internal Parasites: Helminths 1028<br /> Nematodes – <i>Gongylonema, Hyostrongylus, Strongyloides, Ascaris, Trichinella, Trichuris, Oesophagostomum, Metastrongylus, Paragonimus, Stephanurus</i>, and others; Cestodes – <i>Echinococcus, Taenia</i>, and others; parasiticides.</p> <p><b>Section VI Noninfectious Diseases 1041</b></p> <p>68 Nutrient Deficiencies and Excesses 1043<br /> Investigation of nutrient deficiencies or excesses, critical control points, inclusion rates, feed analysis, common nutrient concerns including amino acids, vitamins, and minerals.</p> <p>69 Mycotoxins in Grains and Feeds 1055<br /> Aflatoxin, ochratoxin, citrinin, trichothecenes (T2 toxin, DON), zearalenone, fumonisins.</p> <p>70 Toxic Minerals, Chemicals, Plants, and Gases 1072<br /> Minerals, feed additives, pesticides, toxic plants, nitrite, effects of water quality, toxic gases, ventilation failure.</p> <p>Index 1088</p>

<p>"The 11th edition of Diseases of Swine continues to serve as the gold-standard resource for anything and everything related to swine herd health. With an industry that is constantly changing, this edition does an outstanding job of keeping up with the advanced diagnostic technologies and the latest research on new or emerging diseases and syndromes. The quality of the color images has been greatly improved in this edition, which enhances the presentation of gross and histologic lesions to readers. In a world where animal welfare continues to be moved to the forefront of the minds of consumers, the additions to the animal welfare chapter provide readers with critical science-based research that is necessary for evaluating pig behavior and understanding the animals’ needs to provide optimal welfare. This edition is well organized, and it is easy to search for content by either pathogen or clinical signs. <br />In my opinion, there is no other informational resource that comes close to providing the depth or quality of information on the topic of swine diseases as does this book"- <b>JAVMA - DEC 15, 2019, VOL 255- NO. 12</b></p>

<p><b>THE EDITORS</b> <p><b>JEFFREY J. ZIMMERMAN,</b> DVM, PhD, DACVPM, is Professor of Disease Ecology in the Department of Veterinary Diagnostic and Production Animal Medicine at Iowa State University in Ames, Iowa, USA. <p><b>LOCKE A. KARRIKER,</b> DVM, MS, DACVPM, is Professor of Veterinary Diagnostic and Production Animal Medicine and Director of the Swine Medicine Education Center at Iowa State University in Ames, Iowa, USA. <p><b>ALEJANDRO RAMIREZ,</b> DVM, MPH, PhD, DACVPM, is Associate Professor of Veterinary Diagnostic and Production Animal Medicine at Iowa State University in Ames, Iowa, USA. <p><b>KENT J. SCHWARTZ,</b> DVM, MS, is Clinical Professor and Diagnostician at the Iowa State University Veterinary Diagnostic Laboratory in Ames, Iowa, USA. <p><b>GREGORY W. STEVENSON,</b> DVM, PhD, DACVP, is Professor of Veterinary Pathology and Diagnostic Pathologist at Iowa State University in Ames, Iowa, USA. <p><b>JIANQIANG ZHANG,</b> MD, MS, PhD, is Associate Professor of Veterinary Diagnostic and Production Animal Medicine at Iowa State University in Ames, Iowa, USA.

<p><b>Provides a fully revised Eleventh Edition of the definitive reference to swine health and disease</b> <p><i>Diseases of Swine</i> has been the definitive reference on swine health and disease for over 60 years. This new edition has been completely revised to include the latest information, developments, and research in the field. Now with full color images throughout, this comprehensive and authoritative resource has been redesigned for improved consistency and readability, with a reorganized format for more intuitive access to information. <p><i>Diseases of Swine</i> covers a wide range of essential topics on swine production, health, and management, with contributions from more than 100 of the foremost international experts in the field. This revised edition makes the information easy to find and includes expanded information on welfare and behavior. <p>A key reference for anyone involved in the swine industry, <i>Diseases of Swine, Eleventh Edition:</i> <ul> <li>Presents a thorough revision to the gold-standard reference on pig health and disease</li> <li>Features full color images throughout the book</li> <li>Includes information on the most current advances in the field</li> <li>Provides comprehensive information on swine welfare and behavior</li> <li>Offers a reorganized format to make the information more accessible</li> </ul> <p>Written for veterinarians, academicians, students, and individuals and agencies responsible for swine health and public health, <i>Diseases of Swine, Eleventh Edition</i> is an essential guide to swine health.

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