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Carbon Monoxide in Drug Discovery


Carbon Monoxide in Drug Discovery

Basics, Pharmacology, and Therapeutic Potential
Wiley Series in Drug Discovery and Development 1. Aufl.

von: Binghe Wang, Leo E. Otterbein

192,99 €

Verlag: Wiley
Format: EPUB
Veröffentl.: 10.05.2022
ISBN/EAN: 9781119783428
Sprache: englisch
Anzahl Seiten: 560

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Beschreibungen

<b>CARBON MONOXIDE IN DRUG DISCOVERY</b> <p><b>An insightful reference for the latest physiological and therapeutic studies of carbon monoxide</b> <p>In <i>Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential,</i> a team of distinguished authors delivers foundational knowledge, the latest research, and remaining challenges regarding the physiological roles and therapeutic efficacy of carbon monoxide (CO). The editors have included a broad selection of resources from leading experts in the field that discuss the background and physiological roles of CO, a variety of delivery forms including CO prodrugs using benign carriers, CO sensing, therapeutic applications, and clinical trials. <p>Organized by topic to allow each chapter to be read individually, the book covers a wide range of topics, from physiological and patho-physiological mechanisms at the molecular level to clinical applications for multiple disease processes. <p>The editors of <i>Carbon Monoxide in Drug Discovery</i> have created a compelling argument for shifting the accepted understanding of CO from poison to bioactive molecule with enormous clinical benefits. Readers will also benefit from: <ul><li>A thorough introduction to the background and physiological actions of carbon monoxide, including endogenous CO production in sickness and in health</li> <li>Comprehensive explorations of CO delivery forms, including non-carrier formulations, metal-carbonyl complexes, and organic CO donors</li> <li>Practical discussions of carbon monoxide sensing and scavenging, including fluorescent probes for intracellular carbon monoxide detection</li> <li>In-depth examinations of the therapeutic applications of CO, including CO in solid organ transplantation</li></ul> <p>Perfect for professors, graduate students, and postdocs in the fields of biology, pharmacology, immunology, medicinal chemistry, toxicology, and drug delivery, <i>Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential </i>is also an invaluable resource for industrial scientists in these areas.
<p>List of Contributors viii</p> <p>Preface: Carbon Monoxide: Promises and Challenges in Its Pharmaceutical Development xii</p> <p><b>Section I General Background and Physiological Actions 1</b></p> <p>1 Endogenous CO Production in Sickness and in Health 3<br /> <i>Ladie Kimberly De La Cruz and Binghe Wang</i></p> <p>2 Molecular Mechanisms of Actions for CO: An Overview 27<br /> <i>Rodrigo W. Alves de Souza, Leo E. Otterbein, and Nils Schallner</i></p> <p>3 Pharmacokinetic Characteristics of Carbon Monoxide 44<br /> <i>Xiaoxiao Yang, Mingjia Wang, Chalet Tan, Wen Lu, and Binghe Wang</i></p> <p>4 Carbon Monoxide and Energy Metabolism 88<br /> <i>Daniela Dias-Pedroso, Nuno Soares, and Helena L.A. Vieira</i></p> <p>5 Role of CO in Circadian Clock 97<br /> <i>Hiroaki Kitagishi and Ikuko Sagami</i></p> <p>6 Carbon Monoxide and Mitochondria 108<br /> <i>Claude A. Piantadosi</i></p> <p>7 Carbon Monoxide, Oxygen, and Pseudohypoxia 118<br /> <i>Grace E. Otterbein, Michael S. Tift, and Ghee Rye Lee</i></p> <p>8 Nitric Oxide in Human Physiology: Production, Regulation, and Interaction</p> <p>with Carbon Monoxide Signaling 136<br /> <i>Maryam K. Mohammed and Brian S. Zuckerbraun</i></p> <p>9 When Carbon Monoxide Meets Hydrogen Sulfide 160<br /> <i>Rui Wang Copyrighted Material</i></p> <p>10 Biliverdin and Bilirubin as Parallel Products of CO Formation: Not Just Bystanders 175<br /> <i>Libor Vitek</i></p> <p><b>Section II Delivery Forms 195</b></p> <p>11 Delivery Systems and Noncarrier Formulations 197<br /> <i>James Byrne, Christoph Steiger, Jakob Wollborn, and Giovanni Traverso</i></p> <p>12 Metal-Based Carbon Monoxide-Releasing Molecules (CO-RMs) as Pharmacologically Active Therapeutics 203<br /> <i>Roberta Foresti, Djamal Eddine Benrahla, Shruti Mohan, and Roberto Motterlini</i></p> <p>13 Organic CO Donors that Rely on Photolysis for CO Release 223<br /> <i>Yi Liao</i></p> <p>14 Organic Carbon Monoxide Prodrugs that Release CO Under Physiological Conditions 232<br /> <i>Zhengnan Yuan and Binghe Wang</i></p> <p>15 Targeted Delivery of Carbon Monoxide 259<br /> <i>Lisa M. Berreau</i></p> <p>16 Anesthesia-Related Carbon Monoxide Exposure 286<br /> <i>Richard J. Levy</i></p> <p>17 Natural Products that Generate Carbon Monoxide: Chemistry and Nutritional Implications 302<br /> <i>Ladie Kimberly De La Cruz and Binghe Wang</i></p> <p><b>Section III Carbon Monoxide Sensing and Scavenging 319</b></p> <p>18 Fluorescent Probes for Intracellular Carbon Monoxide Detection 321<br /> <i>Ryan R. Walvoord, Morgan R. Schneider, and Brian W. Michel</i></p> <p><b>Section IV Therapeutic Applications 345</b></p> <p>19 CO in Solid Organ Transplantation 347<br /> <i>Roberta Foresti, Roberto Motterlini, and Stephan Immenschuh</i></p> <p>20 Carbon Monoxide in Lung Injury and Disease 360<br /> <i>Stefan W. Ryter</i></p> <p>21 Carbon Monoxide in Acute Brain Injury and Brain Protection 377<br /> <i>Alexandra Mazur, Madison Fangman, Rani Ashouri, Hannah Pamplin, Shruti Patel, and Sylvain Doré</i></p> <p>22 CO as a Protective Mediator of Liver Injury: The Role of PERK in HO-1/ CO-Mediated Maintenance of Cellular Homeostasis in the Liver 385<br /> <i>Yeonsoo Joe, Jeongmin Park, Mihyang Do, Stefan W. Ryter, Young-Joon Surh, Uh-Hyun Kim, and Hun Taeg Chung</i></p> <p>23 CO and Cancer 401<br /> <i>James N. Arnold and Joanne E. Anstee</i></p> <p>24 CO and Diabetes 423<br /> <i>Rebecca P. Chow and Hongjun Wang</i></p> <p>25 Carbon Monoxide and Acute Kidney Injury 434<br /> <i>Mark de Caestecker</i></p> <p>26 CO as an Antiplatelet Agent: An Energy Metabolism Perspective 453<br /> <i>Patrycja Kaczara, Kamil Przyborowski, Roberto Motterlini, and Stefan Chlopicki</i></p> <p>27 CO in Gastrointestinal Physiology and Protection 466<br /> <i>Katarzyna Magierowska and Marcin Magierowski</i></p> <p>28 Carbon Monoxide and Sickle Cell Disease 482<br /> <i>Edward Gomperts, John Belcher, Howard Levy, and Greg Vercellotti</i></p> <p>29 CO and Pain Management 497<br /> <i>Olga Pol</i></p> <p>30 Clinical Trials of Low-Dose Carbon Monoxide 511<br /> <i>Edward Gomperts, Andrew Gomperts, and Howard Levy</i></p> <p>Index 528</p>
<p><b>Binghe Wang, PhD,</b> is Regents’ Professor of Chemistry, Georgia Research Alliance Eminent Scholar, and Director for the Center for Diagnostics and Therapeutics at Georgia State University.</p> <p><b>Leo E. Otterbein, PhD,</b> is Professor of Surgery at Harvard Medical School.
<p><b>An insightful reference for the latest physiological and therapeutic studies of carbon monoxide</b></p> <p>In <i>Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential,</i> a team of distinguished authors delivers foundational knowledge, the latest research, and remaining challenges regarding the physiological roles and therapeutic efficacy of carbon monoxide (CO). The editors have included a broad selection of resources from leading experts in the field that discuss the background and physiological roles of CO, a variety of delivery forms including CO prodrugs using benign carriers, CO sensing, therapeutic applications, and clinical trials. <p>Organized by topic to allow each chapter to be read individually, the book covers a wide range of topics, from physiological and patho-physiological mechanisms at the molecular level to clinical applications for multiple disease processes. <p>The editors of <i>Carbon Monoxide in Drug Discovery</i> have created a compelling argument for shifting the accepted understanding of CO from poison to bioactive molecule with enormous clinical benefits. Readers will also benefit from: <ul><li>A thorough introduction to the background and physiological actions of carbon monoxide, including endogenous CO production in sickness and in health</li> <li>Comprehensive explorations of CO delivery forms, including non-carrier formulations, metal-carbonyl complexes, and organic CO donors</li> <li>Practical discussions of carbon monoxide sensing and scavenging, including fluorescent probes for intracellular carbon monoxide detection</li> <li>In-depth examinations of the therapeutic applications of CO, including CO in solid organ transplantation</li></ul> <p>Perfect for professors, graduate students, and postdocs in the fields of biology, pharmacology, immunology, medicinal chemistry, toxicology, and drug delivery, <i>Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential </i>is also an invaluable resource for industrial scientists in these areas.

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