Details

Preface. <p>Acnowldegments.</p> <p>1. Introduction to DNA Microarray Technology.</p> <p>2. Image Analysis.</p> <p>3. Basic Data Analysis.</p> <p>4. Visualization by Reduction of Dimensionality.</p> <p>5. Cluster Analysis.</p> <p>6. Molecular Classifiers for Cancer.</p> <p>7. Survival Analysis.</p> <p>8. Meta-Analysis.</p> <p>9. The Design of Probes.</p> <p>10. Software Issues and Data Formats.</p> <p>11. Breast Cancer.</p> <p>12. Leukemia.</p> <p>13. Lymphoma.</p> <p>14. Lung Cancer.</p> <p>15. Bladder Cancer.</p> <p>16. Colon Cancer.</p> <p>17. Ovarian Cancer.</p> <p>18. Prostate Cancer.</p> <p>19. Melanoma.</p> <p>20. Brain Tumors.</p> <p>21. Organ or Tissue Specific Classification.</p> <p>22. Sample Collection and Stability.</p> <p>References.</p> <p>Index.</p>

"…a ground-breaking addition…the best manual presently available on the use of DNA Microarrays in frontline cancer research." (<i>Electric Review</i>, February/March 2007)

<b>STEEN KNUDSEN</b>, PhD, is Director of Research at the Medical Prognosis Institute where he is now taking DNA microarrays into the clinic. Dr. Knudsen is a pioneer in the field of bioinformatics, having published a groundbreaking paper in Nature in 1990. He is also author of the critically acclaimed <i>Guide to the Analysis of DNA Microarray Data</i> (Wiley).

Learn how to use DNA microarrays in the fight against cancer<br /> <br /> <p>This text provides a first-time comprehensive review and analysis of the state of the art in clinical applications of DNA microarray data in cancer diagnostics. The acclaimed author, an international authority in the field, reviews published clinical trials for ten common cancer types. Moreover, the text provides a meta-analysis of these trials to highlight where the results concur.</p> <p>The author begins with a discussion of the state of DNA microarray technology, emphasizing important aspects of data analysis. Emerging technologies within the field of DNA microarrays are presented. Next, readers learn the statistical analysis techniques needed to interpret the data. Finally, the author examines some major human cancer types where microarrays have been applied with success. The author concludes, based on the evidence and his own studies in the field, that the results are so convincing for several cancer types that DNA microarrays are ready to be deployed in clinical practice.</p> <p>The text provides many features for researchers and clinicians who want to use microarrays as a hands-on diagnostic tool, including:</p> <ul> <li>Examples and mini-cases that illustrate real-world applications</li> <li>Further reading suggestions in each chapter to facilitate continued investigation of particular topics</li> <li>Detailed recipes and software code for executing the techniques and analysis described in the text</li> <li>Accessible, straightforward presentations that do not presume special training in statistics or bioinformatics</li> </ul> <p>With the promise of DNA microarrays leading to more accurate cancer diagnoses, this text is an invaluable guide that opens the door to better care for cancer patients.</p>

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