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Preface. <p>1. The Regulation of Gene Expression.</p> <p>2. The Regulation of Enzyme Activity.</p> <p>3. Structure and Function of Signal Pathways.</p> <p>4. Signaling by Nuclear Receptors.</p> <p>5. G Protein-Coupled Signal Transmission Pathways.</p> <p>6. Intracellular Messenger Substances: Second Messengers.</p> <p>7. Ser/Thr-specific Protein Kinases and Protein Phosphatases.</p> <p>8. Signal Transmission via Transmembrane Receptors with Tyrosine-Specific Protein Kinase Activity.</p> <p>9. Signal Transmission via Ras Proteins.</p> <p>10. Intracellular Signal Transduction: The Protein Cascades of the MAP Kinase Pathways.</p> <p>11. Membrane Receptors with Associated Tyrosine Kinase Activity.</p> <p>12. Other Receptor Classes.</p> <p>13. Regulation of the Cell Cycle.</p> <p>14. Malfunction of Signaling Pathways and Tumorigenesis: Oncogenes and Tumor Suppressor Genes.</p> <p>15. Apoptosis.</p> <p>Index.</p>

"This valuable up-to-date information on biochemistry of signal transduction and regulation is directed to advanced students, teachers, and researchers in biochemistry or molecular biology and describes the molecular basis of signal transduction, regulated gene expression, the cell cycle, tumorigenesis and apoptosis. Therefore, this book can be warmly recommended to this above clientele, but it is also a must in the library of all scientists engaged in neighboured or in this special field." (<i>AFS</i>, VOL. 26 2004)

<b>Gerhard Krauss</b> is Professor of Biochemistry at the University of Bayreuth (Germany). His resarch is centered on the mechanism of interaction of DNA binding proteins and their target DNA. He is specifically interested in transcription factor, DNA methyl transferases and nucleotide excision repair.<br /> The idea for a textbook on Signal Transduction and Gene Regulation originated from a lecture course that he has been teaching at Bayreuth since the middle of the 1990s.

This all-new edition of a classic text has been thoroughly revised to keep pace with the rapid progress in signal transduction research. With didactic skill and clarity the author relates the observed biological phenomena to the underlying biochemical processes. <p>Directed to advanced students, teachers, and researchers in biochemistry and molecular biology, this book describes the molecular basis of signal transduction, regulated gene expression, the cell cycle, tumorigenesis and apoptosis.</p> <p>"Provides a comprehensive account of cell signaling and signal transduction and, where possible, explains these processes at the molecular level"<br /> —<i>Angewandte Chemie</i></p> <p>"The clear and didactic presentation makes it a textbook very useful for students and researchers not familiar with all aspects of cell regulation."<br /> —<i>Biochemistry</i></p> <p>"This book is actually two books: Regulation and Signal Transduction."<br /> —<i>Drug Research</i></p>

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