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Preface.<br /> <br /> Acknowledgments.<br /> <br /> Introduction.<br /> <br /> Biomaterials.<br /> <br /> Proteins.<br /> <br /> Protein-Surface Interactions.<br /> <br /> Blood-Biomaterial Interactions and Coagulation.<br /> <br /> Inflammation and Infection.<br /> <br /> The Immune System and Inflammation.<br /> <br /> Wound Healing.<br /> <br /> Biomaterial Surface and the Physiological Environment.<br /> <br /> Biocompatibility.<br /> <br /> Example 1: Opening Occluded Vessels: Vascular Grafts, Intimal Hyperplasia.<br /> <br /> Example 2: Replacing Joints and Teeth.<br /> <br /> Answers to Quiz Questions.<br /> <br /> Gloassry.<br /> <br /> Index.

"...well illustrated with a glossary, end-chapter summaries, and references...materials, scientists, medical device designers and manufacturers, corrosion researchers and practitioners, surgeons, and clinicians will profit from reading this book." (<i>CORROSION</i>, February 2006) <p>"…a concise, topical, and not overly technical hardbound…the strengths of this book are its crisp information and condensed summaries. The jewels of this book are the diagrams and tables." (<i>Annals of Biomedical Engineering</i>, Issue 31:11)</p> <p>"...delivers precisely what the authors intended...excellent book...great introduction...nicely complements existing texts..." (<i>Advanced Materials</i>, Vol 16(4), 17 Feb 2004)</p> <p>"This text would be of great use for faculty teaching courses on tissue-biomaterial interactions." (<i>IEEE Engineering in Medicine and Biology</i>, May/ June 2003)</p> <p>"...a pleasure to read...highly recommendable..." (<i>Biomateria.com</i>)</p> <p>"...excellent attention to detail…recommended for graduate students, faculty and researchers, and bioengineers and physicians." (<i>Choice</i>, Vol. 40, No. 6, February 2003)</p>

<p><strong>Dr. Rena Bizios</strong> received her B.S. in Chemical Engineering from the University of Massachusetts, M.S. in Chemical Engineering from the California Institute of Technology, and Ph.D. in Biomedical Engineering from the Massachusetts Institute of Technology. She is currently a Professor with the faculty of the Biomedical Engineering Department, School of Engineering at Rensselaer Polytechnic Institute in Troy, New York. <p><strong>Dr. Kay C Dee</strong> earned her M.Eng. and Ph.D. degrees in biomedical engineering from Rensselaer Polytechnic Institute. Her research has been awarded by the Biomedical Engineering Society and the National Science Foundation. Dr. Dee has been voted "Teacher of the Year" by the biomedical engineering seniors each of the four years that she has been at Tulane University, and she received the University-wide Inspirational Undergraduate Professor Award in 2001. <p><strong>Dr. David Puleo</strong> received his B.S. and Ph.D. degrees in Biomedical Engineering from Rensselaer Polytechnic Institute, and is currently an Associate Professor in the Center for Biomedical Engineering at the University of Kentucky.

The interaction of tissue and synthetic material can be the pivotal element in the artificial replacement of a body part damaged by disease or trauma. Hip replacements, dental implants, pacemaker leads, vascular grafts, heart valves, and dialysis machines all involve microscopic, tissue-level events that determine the success or failure of such devices. An Introduction to Tissue-Biomaterial Interactions acquaints an undergraduate audience with the fundamental biological processes that influence these sophisticated, cutting-edge procedures.<br /> <br /> Chapters one through three provide more detail about the molecular-level events that happen at the tissue-implant interface, while chapters four through ten explore selected material, biological, and physiological consequences of these events. The importance of the body's wound-healing response is emphasized throughout. Specific topics covered include:<br /> * Structure and properties of biomaterials<br /> * Proteins<br /> * Protein-surface interactions<br /> * Blood-biomaterial interactions<br /> * Inflammation and infection<br /> * The immune system<br /> * Biomaterial responses to implantation<br /> * Biomaterial surface engineering<br /> * Intimal hyperplasia and osseointegration as examples of tissue-biomaterial interactions<br /> <br /> The text also provides extensive coverage of the three pertinent interfaces between the body and the biomaterial, between the body and the living cells, and between the cells and the biomaterial that are critical in the development of tissue-engineered products that incorporate living cells within a biomaterial matrix.<br /> <br /> Ideal for a one-semester, biomedical engineering course, An Introduction to Tissue-Biomaterial Interactions provides a solid framework for understanding today's and tomorrow's implantable biomedical devices.

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