Details

Zika Virus and Diseases


Zika Virus and Diseases

From Molecular Biology to Epidemiology
1. Aufl.

von: Suzane R. da Silva, Fan Cheng, Shou-Jiang Gao

116,99 €

Verlag: Wiley-Blackwell
Format: PDF
Veröffentl.: 14.02.2018
ISBN/EAN: 9781119408659
Sprache: englisch
Anzahl Seiten: 264

DRM-geschütztes eBook, Sie benötigen z.B. Adobe Digital Editions und eine Adobe ID zum Lesen.

Beschreibungen

<p><b>Compiles the most current information on the Zika virus and its associated diseases</b> </p> <p>This comprehensive book provides the most up-to-date information for students, medical students, and scientists on Zika virus and its associated diseases. It includes all the information related to the Zika virus since its discovery in 1947; its epidemic outbreak in 2007-2014; how the epidemiology changed in America in 2015-2016; its mode of transmission; how to prevent and treat it; and associated diseases.</p> <p><i>Zika Virus and Diseases: From Molecular Biology to Epidemiology</i> offers complete and up-to-date coverage in 10 chapters. It presents information from papers that attempted to associate the virus with diseases in Africa until the first animal experiment; discusses its association with Guillain-Barré syndrome and microcephaly; describes the basic mechanisms for Zika (ZIKV) replication, including important differences between Dengue (DENV), West-Nile virus (WNV), and ZIKV; explains the difference between the strains and discusses the pathogenesis of them; covers the papers that showed all the interferences that Zika can cause, and the pathways which can be modified; and more.</p> <ul> <li>The first book since 1947 to put together all the scientific information</li> <li>Compiles all the information received in the last year about Zika virus</li> <li>Clearly demonstrates the origin and discovery of the virus</li> </ul> <p><i>Zika Virus and Diseases: From Molecular Biology to Epidemiology</i> will appeal to graduate students, medical students, basic researchers, clinicians in infectious disease, microbiology, and virology, as well as people in related disciplines interested in learning more about this topic.</p>
<p>Preface ix</p> <p>List of Abbreviations xi</p> <p><b>1 The History of ZIKV Discovery 1</b></p> <p>1.1 ZIKV Isolation from Monkeys and Mosquitos 1</p> <p>1.2 ZIKV Infection in Humans 6</p> <p>1.3 ZIKV Infection Spread to Other Hosts and Regions 7</p> <p>1.4 Cross‐Paths between ZIKV and Other Flaviviruses 9</p> <p>References 10</p> <p><b>2 ZIKV: From Silent to Epidemic 15</b></p> <p>2.1 Outbreak in Yap Island (2007) 15</p> <p>2.2 Outbreak in French Polynesia (2013) 16</p> <p>2.3 How Did ZIKV Reach Brazil? 18</p> <p>2.4 Outbreak in Brazil (2015) 18</p> <p>2.5 ZIKV Spread through South, Central, and North Americas 20</p> <p>References 22</p> <p><b>3 ZIKV Transmission and Prevention 29</b></p> <p>3.1 Modes of Transmission 29</p> <p>3.2 Prevention 37</p> <p>References 40</p> <p><b>4 Association with Guillain‐Barre Syndrome and Microcephaly 49</b></p> <p>4.1 Association with Neurological Disorders 49</p> <p>References 58</p> <p><b>5 ZIKV Animal Models 69</b></p> <p>5.1 Animal Models: Embryonated Hen Eggs 69</p> <p>5.2 Animal Models: Landrace Piglet 69</p> <p>5.3 Animal Models: Mice 70</p> <p>5.4 Animal Model: Nonhuman Primate 74</p> <p>References 78</p> <p><b>6 Biology of ZIKV 83</b></p> <p>6.1 Structural and Physical Properties of ZIKV Virion 84</p> <p>6.2 Binding and Entry 87</p> <p>6.3 Genome Structure 89</p> <p>6.4 Translation and Proteolytic Processing 91</p> <p>6.5 Features of the Nonstructural Proteins 92</p> <p>6.6 RNA Replication 100</p> <p>6.7 Features of the Structural Proteins 104</p> <p>6.8 Virus Assembly and Release from Virus‐Infected Cells 107</p> <p>References 109</p> <p><b>7 Zika Virus (ZIKV) Strains and Lineages 131</b></p> <p>7.1 East and West African Lineage 131</p> <p>7.2 Africa vs. Asian/American Lineage 132</p> <p>References 140</p> <p><b>8 ZIKV‐Host Interactions 147</b></p> <p>8.1 Systematic Studies to Identify ZIKV Affected Functions and Pathways 147</p> <p>8.2 Induction and Dysregulation of Innate Immune Responses during ZIKV Infection 150</p> <p>8.3 Induction of Cell Death and Apoptosis by ZIKV 156</p> <p>8.4 Induction of Autophagy by ZIKV 160</p> <p>8.5 Dysregulation of Cell Cycle and Induction of Abnormal Mitosis by ZIKV 163</p> <p>References 164</p> <p><b>9 Inhibitors of ZIKV Replication and Infection 179</b></p> <p>9.1 Drugs That Lead to the Destruction of ZIKV Virions 179</p> <p>9.2 Drugs That Inhibit ZIKV Entry and Endocytosis 180</p> <p>9.3 Drugs That Target ZIKV NS2B‐NS3 Protease Activity 186</p> <p>9.4 Drugs That Target ZIKV NS5 RNA‐Dependent RNA Polymerase Activity 191</p> <p>9.5 Neutralizing Antibodies That Target ZIKV Structural Protein 200</p> <p>9.6 Drugs That Inhibit ZIKV Infection by Targeting Host Machinery 201</p> <p>9.7 Drugs That Show Neuroprotective Activity but Do Not Suppress ZIKV Replication: Emricasan 205</p> <p>9.8 Other Drugs That Inhibit ZIKV Infection Identified from a Screening of FDA‐Approved Drugs 206</p> <p>References 210</p> <p><b>10 Long‐Term Care and Perspectives 229</b></p> <p>10.1 Prenatal Care and Diagnosis of Abnormal Fetus Development 229</p> <p>10.2 Long‐Term Care for Patients Affected by ZIKV 230</p> <p>10.3 Assistance to Families with Children Affected by ZIKV 230</p> <p>10.4 Perspectives 231</p> <p>References 232</p> <p>Index 237</p>
<p><b>Suzane Ramos da Silva, Fan Cheng and Shou-Jiang Gao,</b> Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
<p><b>Compiles the most current information on the Zika virus and its associated diseases</b> <p>This comprehensive book provides the most up-to-date information for students, medical students, and scientists on Zika virus and its associated diseases. It includes all the information related to the Zika virus since its discovery in 1947; its epidemic outbreak in 2007–2014; how the epidemiology changed in America in 2015–2016; its mode of transmission; how to prevent and treat it; and associated diseases. <p><i>Zika Virus and Diseases: From Molecular Biology to Epidemiology</i> offers complete and up-to-date coverage in 10 chapters. It presents information from papers that attempted to associate the virus with diseases in Africa until the first animal experiment; discusses its association with Guillain-Barré syndrome and microcephaly; describes the basic mechanisms for Zika (ZIKV) replication, including important differences between Dengue (DENV), West-Nile virus (WNV), and ZIKV; explains the difference between the strains and discusses the pathogenesis of them; covers the papers that showed all the interferences that Zika can cause, and the pathways which can be modified; and more. <ul> <li>The first book since 1947 to put together all the scientific information</li> <li>Compiles all the information received in the last year about Zika virus</li> <li>Clearly demonstrates the origin and discovery of the virus</li></ul>

Diese Produkte könnten Sie auch interessieren:

Zukunftstechnologie Tissue Engineering
Zukunftstechnologie Tissue Engineering
von: Will W. Minuth, Raimund Strehl, Karl Schumacher
PDF ebook
114,99 €
Biologische Bodensanierung
Biologische Bodensanierung
von: Kassem Alef
PDF ebook
40,99 €
Zukunftstechnologie Tissue Engineering
Zukunftstechnologie Tissue Engineering
von: Will W. Minuth, Raimund Strehl, Karl Schumacher
EPUB ebook
114,99 €