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<p>Contributors vii</p> <p>Preface xi</p> <p><b>Part 1 Molecular Signaling Mechanisms: From Pathways to Networks 1</b></p> <p>1 Wnt Signal Production, Secretion, and Diffusion 3<br /> <i>Madelon M. Maurice and Hendrik C. Korswagen</i></p> <p>2 Wnt Signaling at the Membrane 15<br /> <i>Gary Davidson and Christof Niehrs</i></p> <p>3 Wnt Signal Transduction in the Cytoplasm: an Introduction to the Destruction Complex 33<br /> <i>Tony W. Chen, Heather A. Wallace, Yashi Ahmed, and Ethan Lee</i></p> <p>4 An Overview of Gene Regulation by Wnt/β-Catenin Signaling 51<br /> <i>Chen U. Zhang and Ken M. Cadigan</i></p> <p>5 Finding a Needle in a Genomic Haystack: Genome-Wide Approaches to Identify Wnt/TCF Transcriptional Targets 73<br /> <i>Chandan Bhambhani and Ken M. Cadigan</i></p> <p>6 Introduction to β-Catenin-Independent Wnt Signaling Pathways 89<br /> <i>Susanne Kühl and Michael Kühl</i></p> <p>7 Molecular Mechanisms of Wnt Pathway Specificity 101<br /> <i>Alexandra Schambony, Guido J.R. Zaman, and Folkert Verkaar</i></p> <p>8 Modulation of Wnt Signaling by Endocytosis of Receptor Complexes 113<br /> <i>Akira Kikuchi, Shinji Matsumoto, Katsumi Fumoto, and Akira Sato</i></p> <p>9 New Insights from Proteomic Analysis of Wnt Signaling 125<br /> <i>Matthew P. Walker, Dennis Goldfarb, and Michael B. Major</i></p> <p>10 New Insights about Wnt/β-Catenin Pathway Mechanisms from Global siRNA Screens 137<br /> <i>Tenzin Gocha and Ramanuj DasGupta</i></p> <p>11 Mathematical Models of Wnt Signaling Pathways 153<br /> <i>Michael Kühl, Barbara Kracher, Alexander Groß, and Hans A. Kestler</i></p> <p>12 The Wnt’s Tale: On the Evolution of a Signaling Pathway 161<br /> <i>Jenifer C. Croce and Thomas W. Holstein</i></p> <p><b>Part 2 Selected Key Molecules in Wnt Signaling 177</b></p> <p>13 Secreted Wnt Inhibitors or Modulators 179<br /> <i>Paola Bovolenta, Anne-Kathrin Gorny, Pilar Esteve, and Herbert Steinbeisser</i></p> <p>14 Frizzleds as G Protein-Coupled Receptors 195<br /> <i>Gunnar Schulte</i></p> <p>15 Dishevelled at the Crossroads of Pathways 207<br /> <i>Vítìzslav Bryja and Ondøej Bernatík</i></p> <p>16 β-Catenin: a Key Player in Both Cell Adhesion and Wnt Signaling 217<br /> <i>Jonathan Pettitt</i></p> <p>17 Evolutionary Diversification of Vertebrate TCF/LEF Structure, Function, and Regulation 225<br /> <i>Stefan Hoppler and Marian L. Waterman</i></p> <p>18 Insights from Structural Analysis of Protein–Protein Interactions by Wnt Pathway Components and Functional Multiprotein Complex Formation 239<br /> <i>Zhihong Cheng and Wenqing Xu</i></p> <p><b>Part 3 Wnt Signaling in Embryonic Development and Adult Tissue Homeostasis 251</b></p> <p>19 Wnt Signaling in Early Vertebrate Development: From Fertilization to Gastrulation 253<br /> <i>Eliza Zylkiewicz, Sergei Y. Sokol, and Stefan Hoppler</i></p> <p>20 Wnt/β-Catenin Signaling in Embryonic Stem Cells: Insights into Early Mammalian Development 267<br /> <i>Kathryn C. Davidson</i></p> <p>21 Wnt Signaling in Neural Development 279<br /> <i>Richard I. Dorsky</i></p> <p>22 Wnt Signaling in Heart Organogenesis 293<br /> <i>Stefan Hoppler, Silvia Mazzotta, and Michael Kühl</i></p> <p>23 Wnt Signaling in Kidney Organogenesis 303<br /> <i>Kimmo Halt and Seppo Vainio</i></p> <p>24 Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer 315<br /> <i>Theodora Fifis, Bang M. Tran, Renate H.M. Schwab, Timothy M. Johanson, Nadia Warner, Nick Barker, and Elizabeth Vincan</i></p> <p><i>25 Wnt Signaling in Adult Stem Cells: Tissue Homeostasis and Regeneration 329</i><br /> <i>Frank J.T. Staal and Riccardo Fodde</i></p> <p>26 Restoring Tissue Homeostasis: Wnt Signaling in Tissue Regeneration After Acute Injury 339<br /> <i>Günes Özhan and Gilbert Weidinger</i></p> <p><b>Part 4 Wnt Signaling in Chronic Disease 357</b></p> <p>27 Wnt Signaling and Colorectal Cancer 359<br /> <i>Kevin Myant and Owen J. Sansom</i></p> <p>28 Wnt Signaling in Melanoma 369<br /> <i>Jamie N. Anastas and Andy J. Chien</i></p> <p>29 Wnt Signaling in Mood and Psychotic Disorders 379<br /> <i>Stephen J. Haggarty, Karun Singh, Roy H. Perlis, and  Rakesh Karmacharya</i></p> <p>30 Neuropsychiatric Disease-Associated Genetic Variation in the Wnt Pathway 393<br /> <i>Stephen J. Haggarty, Karun Singh, Roy H. Perlis, and Rakesh Karmacharya</i></p> <p>31 Wnt Signaling in Dementia 411<br /> <i>Stephen J. Haggarty</i></p> <p>32 Therapeutic Targeting of the Wnt Signaling Network 421<br /> <i>Felicity Rudge and Trevor Dale</i></p> <p>Index 445</p>

<b>Stefan P. Hoppler</b>, PhD, is Professor in Developmental Biology at the School of Medical Sciences at the University of Aberdeen. In addition to his teaching duties Prof. Hoppler runs research programs looking at Wnt inhibitors in heart muscle differentiation and tissue-specific regulation of gene expression by Wnt/beta-catenin signalling, and he also serves on the editorial board for the journal <i>Developmental Dynamics</i>. <p><b>Randall T. Moon</b>, PhD, is Professor of Pharmacology at the University of Washington School of Medicine. His lab focuses on identifying the normal roles of Wnt signaling in embryos and adults and applying that knowledge to develop therapies for acute and chronic medical conditions involving Wnt signaling. Dr. Moon is Founding Director of the University of Washington Institute for Stem Cell and Regenerative Medicine, and a member of the Paul Allen Brain Institute Cell Networks Advisory Council, the HHMI Medical Research Fellows Program panel, and College of CSR Reviewers for NIH.</p>

<i>Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions</i> reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion of cutting-edge scientific research. Focused on the biological insights and current scientific questions of Wnt signaling, this book will be a comprehensive and definitive resource for a wide range of researchers and students in cell signaling, cell physiology, developmental biology, and biomedical engineering, as well as anyone interested in learning more about this important and complex protein network. <br /> <br /> • A definitive source of information on Wnt signaling and its role in development and disease, written by leaders in the field.<br /> <br /> • Explores the role of Wnt signaling in chronic disease such as melanoma, colorectal cancer, dementia, and psychiatric diseases<br /> <br /> • Reviews the complex processes of signal integration and regulation<br /> <br /> • Features broad discussion of Wnt signaling biology as well as detailed discussion of the pathway’s role in diseases and potential clinical applications.

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