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<p>PREFACE ix</p> <p>CONTRIBUTORS xi</p> <p><b>SECTION 1: UREMIC TOXINS 1</b></p> <p>1. Uremic Toxins: An Integrated Overview of Definition and Classification 3<br /> <i>Richard J. Glassock and Shaul G. Massry</i></p> <p>2. Classification and a List of Uremic Toxins 13<br /> <i>Nathalie Neirynck, Rita De Smet, Eva Schepers, Raymond Vanholder, and Griet Glorieux</i></p> <p>3. Analysis of Uremic Toxins with Mass Spectrometry 35<br /> <i>Toshimitsu Niwa</i></p> <p><b>SECTION 2: SELECTED UREMIC TOXINS 51</b></p> <p>4. Indoxyl Sulfate 53<br /> <i>Toshimitsu Niwa</i></p> <p>5. p-Cresyl Sulfate 77<br /> <i>Anneleen Pletinck, Raymond Vanholder, and Griet Glorieux</i></p> <p>6. 3-Carboxy-4-methyl-5-propyl-2-furanpropionic Acid 87<br /> <i>Toshimitsu Niwa</i></p> <p>7. Phenylacetic Acid 99<br /> <i>Anna Schulz and Joachim Jankowski</i></p> <p>8. Homocysteine and Hydrogen Sulfide, Two Opposing Aspects in the Pathobiology of Sulfur Compounds in Chronic Renal Failure 109<br /> <i>Alessandra F. Perna and Diego Ingrosso</i></p> <p>9. Guanidino Compounds 125<br /> <i>Sunny Eloot, Griet Glorieux, Peter Paul De Deyn, and Raymond Vanholder</i></p> <p>10. Asymmetric Dimethylarginine 143<br /> <i>Vladimýr Teplan and Jaroslav Racek</i></p> <p>11. Nicotinamide Metabolites 163<br /> <i>Boleslaw Rutkowski and Przemyslaw Rutkowski</i></p> <p>12. Dicarbonyls (Glyoxal, Methylglyoxal, and 3-Deoxyglucosone) 177<br /> <i>Naila Rabbani and Paul J. Thornalley</i></p> <p>13. Glucose Degradation Products in Peritoneal Dialysis 193<br /> <i>Monika Pischetsrieder and Sabrina Gensberger</i></p> <p>14. Dinucleoside Polyphosphates 209<br /> <i>Joachim Jankowski and Vera Jankowski</i></p> <p>15. Parathyroid Hormone 227<br /> <i>Shaul G. Massry and Miroslaw Smogorzewski</i></p> <p>16. b2-Microglobulin 249<br /> <i>Suguru Yamamoto, Junichiro James Kazama, Hiroki Maruyama, Ichiei Narita, and Fumitake Gejyo</i></p> <p>17. Cytokines 259<br /> <i>Bj€orn Anderstam, Bengt Lindholm, and Peter Stenvinkel</i></p> <p>18. Free Immunoglobulin Light Chains 279<br /> <i>Gerald Cohen and Walter H. H€orl</i></p> <p>19. Advanced Glycation Endproducts (AGEs) 293<br /> <i>Naila Rabbani and Paul J. Thornalley</i></p> <p>20. Oxidized Albumin 305<br /> <i>Maurizio Bruschi, Giovanni Candiano, Laura Santucci, and Gian Marco Ghiggeri</i></p> <p><b>SECTION 3: THERAPEUTIC REMOVAL OF UREMIC TOXINS 315</b></p> <p>21. Therapeutic Removal of Uremic Toxins by Hemodialysis 317<br /> <i>Tammy L. Sirich, Pavel Aronov, and Timothy W. Meyer</i></p> <p>22. Therapeutic Removal of Uremic Toxins by Peritoneal Dialysis 331<br /> Malgorzata Debowska, Elvia Garcýa-Lopez, Jacek Waniewski, and Bengt Lindholm</p> <p>23. Therapeutic Removal of Uremic Toxins by Oral Sorbent 359<br /> <i>Toshimitsu Niwa</i></p> <p>INDEX 373</p>

<p><b>TOSHIMITSU NIWA, MD, PhD,</b> is Professor in the Department of Advanced Medicine for Uremia at the Nagoya University Graduate School of Medicine. President of the Japanese Society for Biomedical Mass Spectrometry, Dr. Niwa has received many honors for his research, including the Kimoto Prize of the Japanese Society for Dialysis Therapy and the International Society of Uremia Research and Toxicity Award. He has published more than 300 articles in peer-reviewed journals.</p>

<p><b>Reviews all the latest basic and clinical research findings</b></p> <p>With contributions from leading international experts in the field, this book is dedicated to all facets of uremic toxins research, including low molecular weight solutes, protein-bound solutes, and middle molecules. Moreover, it covers everything from basic mass spectrometry research to the latest clinical findings and practices.</p> <p><i>Uremic Toxins</i> is divided into three sections:</p> <ul> <li><b>Section One,</b> Uremic Toxins, explores the definition, classification, listing, and mass spectrometric analysis of uremic toxins</li> <li><b>Section Two,</b> Selected Uremic Toxins, describes key uremic toxins, explaining chemical structures, metabolism, analytical methods, plasma levels, toxicity, clinical implications, and removal methods. Among the uremic toxins covered are indoxyl sulfate, asymmetric dimethylarginine, PTH, ß2-microglobulin, and AGEs</li> <li><b>Section Three,</b> Therapeutic Removal of Uremic Toxins, describes how uremic toxins can be removed by hemodialysis, peritoneal dialysis, and oral sorbent</li> </ul> <p>All chapters are based on the authors' thorough review of the literature as well as their own personal laboratory and clinical experience. References at the end of each chapter provide a gateway to the literature in the field.</p> <p>Reviewing all the latest basic and clinical research findings, <i>Uremic Toxins</i> will help bench scientists in nephrology advance their own investigations. It will also help clinicians take advantage of the latest tested and proven treatments for the management of chronic kidney disease.</p>

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