Details

Upstream Industrial Biotechnology, 2 Volume Set


Upstream Industrial Biotechnology, 2 Volume Set


1. Aufl.

von: Michael C. Flickinger

475,99 €

Verlag: Wiley
Format: PDF
Veröffentl.: 18.07.2013
ISBN/EAN: 9781118619230
Sprache: englisch
Anzahl Seiten: 1854

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Beschreibungen

Biotechnology represents a major area of research focus, and many universities are developing academic programs in the field. This guide to biomanufacturing contains carefully selected articles from Wiley's <i>Encyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology</i> as well as new articles (80 in all,) and features the same breadth and quality of coverage and clarity of presentation found in the original. For instructors, advanced students, and those involved in regulatory compliance, this two-volume desk reference offers an accessible and comprehensive resource.
<p>VOLUME I: EXPRESSION SYSTEMS & PROCESS DEVELOPMENT</p> <p>PREFACE xi</p> <p>CONTRIBUTORS xiii</p> <p><b>PART I INTRODUCTION 3</b></p> <p><b>PART II INDUSTRIAL CELL GROWTH AND GENE EXPRESSION SYSTEMS 7</b></p> <p>1 Animal Cells, Suspension Culture 9<br /><i>John R. Birch</i></p> <p>2 Baculovirus Expression Systems 19<br /><i>Robert D. Possee, Richard B. Hitchman, and Linda A. King</i></p> <p>3 Baculovirus Kinetics, Insect Culture 33<br /><i>Leslie Chan, Steve Reid, and Lars Keld Nielsen</i></p> <p>4 Cell Culture, Aseptic Techniques 49<br /><i>John M. Davis and Kevin L. Shade</i></p> <p>5 Cell Cycle in Bioprocesses 71<br /><i>Mariam Naciri and Mohamed Al-rubeai</i></p> <p>6 Cell Growth and Protein Expression Kinetics 85<br /><i>Dhinakar S. Kompala</i></p> <p>7 Cell Viability Measurement 97<br /><i>Ning Wei and Benjamin Sommer</i></p> <p>8 Contamination Detection in Animal Cell Culture 105<br /><i>Carol Mclean and Colin Harbour</i></p> <p>9 Culture Collections and Biological Resource Centers (BRCs) 131<br /><i>David Smith</i></p> <p>10 Culture Preservation 153<br /><i>Robert L. Gherna</i></p> <p>11 Expression and Secretion of Heterologous Proteins, Bacillus and Other Gram-Positive Bacteria 163<br /><i>Boyke Bunk, Rebekka Biedendieck, Dieter Jahn, and Patricia S. Vary</i></p> <p>12 Gene Expression in Human Cells 181<br /><i>Marco A. Cacciuttolo, Gene Lee, John Chon, and John Lewis</i></p> <p>13 Gene expression in Pichia and other methylotroph yeast 195<br /><i>Koti Sreekrishna</i></p> <p>14 Gene Expression in Recombinant Animal Cells and Transgenic Animals 213<br /><i>Richard M. Twyman and Bruce Whitelaw</i></p> <p>15 Inoculum Expansion Methods, Animal Cell Lines 297<br /><i>Claudia Kloth, Glenn Maclsaac, Haile Ghebremariam, and Alahari Arunakumari</i></p> <p>16 Insect Cell Culture 311<br /><i>Someet Narang, Erik M. Whiteley, Sunyia Hussain, and Michael J. Betenbaugh</i></p> <p>17 Kinetics of Microbial Growth 331<br /><i>Nicolai S. Panikov</i></p> <p>18 Microalgae, Mass Culture Methods 371<br /><i>Emílio Molina Grima, Jose María Fernández Sevilla, and Francisco Gabriel Acién Fernández</i></p> <p>19 Microbial Growth Measurement 399<br /><i>Arthur L. Koch</i></p> <p>20 Microbial Media Composition 413<br /><i>Rosalie J. Cote</i></p> <p>21 Microscopic Characterization of Cells 437<br /><i>Erwin Huebner</i></p> <p>22 Mycoplasma Contamination of Cell Cultures 467<br /><i>Cord C. Uphoff and Hans G. Drexler</i></p> <p>23 Protein Glycosylation: Analysis, Characterization, and Engineering 489<br /><i>Mikael R. Andersen, Jong Hyun Nam, and Susan T. Sharfstein</i></p> <p>24 Secretion of Heterologous Proteins, Gram Positive Bacteria 543<br /><i>Eric Morello, Isabelle Poquet, Philippe Langella</i></p> <p>25 Soluble Protein Expression in Bacteria 557<br /><i>Catherine H. Schein</i></p> <p><b>PART III MEDIA, CELL LINES AND PROCESS DEVELOPMENT 579</b></p> <p>26 Animal Cell Culture Media 581<br /><i>Natarajan Vijayasankaran, Jincai Li, Robert Shawley, Aaron Chen, Masaru Shiratori, Martin Gawlitzek, Feng Li, Robert Kiss, and Ashraf Amanullah</i></p> <p>27 Animal Cell Culture, Effects of Osmolality and Temperature 599<br /><i>James C. Warren and Shyamsundar Subramanian</i></p> <p>28 Animal Cell Stability 617<br /><i>Martin S. Sinacore, Timothy S. Charlebois, Denis Drapeau, Mark Leonard, Scott Harrison, and S. Robert Adamson</i></p> <p>29 Animal Cell Types, Hybridomas 635<br /><i>K. Heilmann and B. Micheel</i></p> <p>30 Antibody Production, Human Recombinant 645<br /><i>Stefan Dübel</i></p> <p>31 Antifoams and Pluronic Polyols, Cell Protection 663<br /><i>David W. Murhammer</i></p> <p>32 Biominiaturization of Bioreactors 669<br /><i>Michael A. Hanson and Govind Rao</i></p> <p>33 Inoculum Preparation 699<br /><i>Craig J.L. Gershater</i></p> <p>34 Microcarrier Culture 711<br /><i>Susan T. Sharfstein and Christian Kaisermayer</i></p> <p>35 Monoclonal Antibody Production, Cell Lines 733<br /><i>Julia F. Markusen and David K. Robinson</i></p> <p>36 Plant Cell Culture, Laboratory Techniques 747<br /><i>Mark Richard Fowler</i></p> <p>37 Scale-Up of Biotechnological Processes 759<br /><i>Marko Zlokarnik</i></p> <p><b>VOLUME II: EQUIPMENT, PROCESS DESIGN, SENSING, CONTROL, AND cGMP OPERATIONS</b></p> <p>PREFACE ix</p> <p>CONTRIBUTORS xi</p> <p><b>PART IV BIOREACTOR DESIGN, ENGINEERING, PROCESS SENSING AND CONTROL 789</b></p> <p>38 Aeration, Mixing, and Hydrodynamics in Animal Cell Bioreactors 791<br /><i>Ruben Godoy-Silva, Claudia Berdugo, and Jeffrey J. Chalmers</i></p> <p>39 Biocatalytic Membrane Reactors 821<br /><i>Lidietta Giorno and Enrico Drioli</i></p> <p>40 Bioreactor Scale-Down 847<br /><i>Laura A. Palomares, Alvaro R. Lara, and Octavio T. Ramírez</i></p> <p>41 Bioreactor Scale-Up 863<br /><i>Laura A. Palomares and Octavio T. Ramírez</i></p> <p>42 Bioreactors: Airlift Reactors 887<br /><i>J.C. Merchuk and F. Garcia Camacho</i></p> <p>43 Bioreactors, Continuous Culture of Plant Cells 955<br /><i>H.J.G. Ten Hoopen</i></p> <p>44 Bioreactors, Fluidized-Bed 963<br /><i>Winfried Storhas</i></p> <p>45 Bioreactors, Gas-Treatment 979<br /><i>Graham Andrews and William Apel</i></p> <p>46 Bioreactors, Perfusion 995<br /><i>Wei Wen Su</i></p> <p>47 Bioreactors: Rotating Biological Contactors 1013<br /><i>Susana Cortez, Pilar Teixeira, Rosário Oliveira, and Manuel Mota</i></p> <p>48 Bioreactors, Stirred Tank for Culture of Plant Cells 1031<br /><i>Pauline M. Doran</i></p> <p>49 Cell Immobilization, Engineering Aspects 1069<br /><i>Ronnie Willaert</i></p> <p>50 Fermenter/Bioreactor Design 1101<br /><i>Marvin Charles and Jack Wilson</i></p> <p>51 Gas-Holdup in Bioreactors 1137<br /><i>Christian Sieblist and Andreas Lübbert</i></p> <p>52 Immobilization of Proteins and Enzymes, Mesoporous Supports 1147<br /><i>Martin Hartmann and Dirk Jung</i></p> <p>53 Immobilized Cells 1179<br /><i>Manojlovic Verica, Bugarski Branko, and Nedovic Viktor</i></p> <p>54 Immobilized Enzymes 1201<br /><i>Jose M. Guisan, Lorena Betancor, and Gloria Fernandez-Lorente</i></p> <p>55 Impeller Selection, Animal Cell Culture 1219<br /><i>Alvin W. Nienow</i></p> <p>56 Mammalian Cell Bioreactors 1233<br /><i>Weichang Zhou, Gargi Seth, Maria J. Guardia, and Wei-Shou Hu</i></p> <p>57 Mammalian Cell Culture Reactors, Scale-Up 1245<br /><i>J. Bryan Griffiths</i></p> <p>58 Mass Transfer 1261<br /><i>Yusuf Chisti</i></p> <p>59 Oxygen Transfer Rate Determination Methods 1303<br /><i>Felix Garcia-Ochoa and Emilio Gomez</i></p> <p>60 Photobioreactors 1327<br /><i>Mario R. Tredici, Graziella Chini Zittelli and Liliana Rodolfi</i></p> <p>61 Rheological Behavior of Fermentation Fluids 1347<br /><i>Colin R. Thomas and Grainne L. Riley</i></p> <p>62 Rheology of Filamentous Microorganisms, Submerged Culture 1359<br /><i>Maria Papagianni</i></p> <p>63 Sampling and Sample Handling for Process Control 1377<br /><i>Bo Mattiasson and Martin Hedström</i></p> <p>64 Solid State Fermentation, Kinetics 1387<br /><i>David A. Mitchell, Deidre M. Stuart, and Robert D. Tanner</i></p> <p>65 Solid Substrate Fermentation, Automation 1413<br /><i>Mario Fernández-fernández and J. Ricardo Pérez-correa</i></p> <p>66 Stainless Steels 1427<br /><i>C.P. Dillon</i></p> <p>67 Static Mixing, Fermentation Processes 1435<br /><i>Radu Z. Tudose and Maria Gavrilescu</i></p> <p>68 Transfer Phenomena in Multiphase Systems 1451<br /><i>Rodica-Viorica Roman</i></p> <p><b>PART V PROCESS ANALYTICAL TECHNOLOGIES (PAT) 1469</b></p> <p>69 Bioprocess and Fermentation Monitoring 1471<br /><i>Michael Pohlscheidt, Salim Charaniya, Marco Jenzsch, Christopher Bork, Tim L. Noetzel, and Andreas Luebbert</i></p> <p>70 Flow Injection Analysis in Industrial Biotechnology 1493<br /><i>Elo Harald Hansen and Manuel Miró</i></p> <p>71 Fluorescence Techniques for Bioprocess Monitoring 1511<br /><i>Fabienne Anton, Carsten Lindemann, Bernd Hitzmann, Kenneth F. Reardon, and Thomas Scheper</i></p> <p>72 Off-Line Analysis in Animal Cell Culture 1523<br /><i>Heino Büntemeyer</i></p> <p>73 Process Analytical Technology: Strategies for Biopharmaceuticals 1543<br /><i>Anurag S. Rathore and Gautam Kapoor</i></p> <p>74 Vent Gas Analysis 1567<br /><i>David Pollard and Jens Christensen</i></p> <p><b>PART VI UPSTREAM cGMP OPERATIONS 1585</b></p> <p>75 Antibody Manufacture, Disposable Systems 1587<br /><i>Regine Eibl and Dieter Eibl</i></p> <p>76 Bioreactor Operations 1595<br /><i>David R. Gray</i></p> <p>77 Bioreactors, Cell Culture, Commercial Production 1635<br /><i>Tan-Che Zhou, Wen-Wen Zhou, Weiwei Hu, and Jian-Jiang Zhong</i></p> <p>78 Biotransformation, Process Optimization 1665<br /><i>Lutz Hilterhaus, Andreas Liese, and Udo Kragl</i></p> <p>79 Foam Formation and Control in Bioreactors 1679<br /><i>Frank Delvigne and Jean-Paul Lecomte</i></p> <p>80 Pilot Plants, Design and Operation 1695<br /><i>Beth H. Junker</i></p> <p>81 Shear Sensitivity 1719<br /><i>Yusuf Chisti</i></p> <p>82 Sterilization and Decontamination, Bioprocess Equipment 1763<br /><i>Peter L. Roberts</i></p> <p>INDEX 1781</p>
<p><strong>Editor-in-Chief, Dr. Michael C. Flickinger</strong> is the Associate Director for Academic Programs of the Golden LEAF Biomanufacturing Training and Education Center (BTEC) and a Professor of Microbiology and Chemical and Biomolecular Engineering at North Carolina State University, Raleigh.<br />Dr. Flickinger was Director of the University of Minnesota's Institute for Advanced Studies in Biological Process Technology, which was later renamed the Biotechnology Institute ), and a Professor of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota, St. Paul. Prior to coming to Minnesota Dr. Flickinger was Director of the Fermentation Program at the National Cancer Institute in Frederick, Maryland.<br />Dr. Flickinger received his academic training at the University of Wisconsin, Madison.?(B.S.?(1973) in microbial biochemistry;? M.S. (1975) and Ph.D.?(1977) in pharmaceutical biochemistry.)? He did his postdoctoral work at the Laboratory for Renewable Resources Engineering? in the School of Chemical Engineering, Purdue University.<br />He is Editor-in-Chief of the <em>Encyclopedia of Industrial Biotechnology</em> (Wiley, 2010) and Co-Editor of the <em>Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis and Bioseparation</em> (Wiley, 1999).

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