Details

Translational Medicine


Translational Medicine

Molecular Pharmacology and Drug Discovery
Current Topics from the Encyclopedia of Molecular Cell Biology and Molecular Medicine 1. Aufl.

von: Robert A. Meyers

358,99 €

Verlag: Wiley-Blackwell
Format: PDF
Veröffentl.: 02.03.2018
ISBN/EAN: 9783527687190
Sprache: englisch
Anzahl Seiten: 1100

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Beschreibungen

This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.
Cancer Biomarkers Inflammatory and Immunological Biomarkers Metabolic phenotyping Neurological Biomarkers Protein Biomarkers Translation of Biomarkers into Clinical Practice Antibody Molecules, Genetic Engineering of Genetic Engineering of Hemoglobin Genetic Engineering of Vaccines Pharmacology and Emerging Clinical Application of RNA Plant-based Expression of Biopharmaceuticals RNAi Gene Therapy to Combat HIV-1 Infection RNAi to Treat Chronic Hepatitis B Virus Infection RNAi to Treat Chronic Hepatitis C Infection Sex Hormones (Male): Analogs and Antagonists Somatic Gene Therapy Vaccine Research and Development Biotransformations of Drugs and Chemicals Drug Bioavailability, Distribution and Clearance Prediction Microbial Metagenomics and Drug Bioavailability, Toxicity and Efficacy Pharmacokinetics and Pharmacodynamics of Biotech Drugs Liposome Gene Transfection Nanometer-scale Polymers for Enhancing Drug Delivery Physical Pharmacy and Biopharmaceutics Preclinical Form & Formulation for Drug Discovery Targeting and Intracellular Delivery of Drugs Transporters in Translational Medicine Vaccination, Genetic Vector Targeting in Gene Therapy Virus-free Gene Transfer systems in Somatic Gene Therapy Alzheimer's Disease Drug Development Antisense Oligonucleotides as Potential Drugs Artificial Organs and Tissues for Drug Discovery Biomarkers in oncology drug development Exploiting Model Organisms for Disease Intervention Generic versions of therapeutic proteins (Biosimilars) Approaches and Problems HIV Prevention Pharmaceuticals Development (pre-exposure prophylaxis (PrEP). ) Natural Products Based Drug Discovery Nucleic Acid Metabolism and Drug Discovery Organic Chemistry in Drug Discovery Pharmacogenomics and Drug Design Predictive Drug Safety Receptor Targets in Drug Discovery Structure-based Drug Design and NMR-based Screening Therapeutic Compounds in Nature as Leads for New Pharmaceuticals Triacylglycerol Storage and Mobilization, Storage of Tuberculosis Drug Development Combinations of Agents for the Diagnosis, Therapeutic or Prognosis Testing Experimental Design, Conduct, and Analysis of Clinical Trials Novel Therapeutics for Targeting Pain Analysis and Pharmaceutical Quality Bioprocess Engineering Pharmaceutical Process Chemistry Production and Commercialization of new Biotechnology Based Pharmaceuticals Xenotransplantation in Pharmaceutical Biotechnology Antibody-enabled small-molecule drug discovery Antimalarial Drug Discovery Discovery and Development of Small Molecule Cancer Drugs High-throughput behavioral profiling to discover and Characterize Psychotropic Drugs Hit-to-Lead Medicinal Chemistry
Robert A. Meyers obtained his Ph.D. in Chemistry at the University of California at Los Angeles. He was a post-doctoral fellow at the California Institute of Technology and has more than 17 patents, 50 technical papers and 12 books to his name. As Editor-in-Chief he conceived and edited several ambitious multivolume reference works, e.g. the Encyclopedia of Analytical Chemistry (Wiley), the Encyclopedia of Molecular Biology and Molecular Medicine (Wiley-VCH) and the Encyclopedia of Physical Science and Technology (Academic Press).

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