The PancreasAn Integrated Textbook of Basic Science, Medicine, and Surgery
This brand new updated edition of the most comprehensive reference book on pancreatic disease details the very latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known disorders. Included for the first time, are two brand new sections on the key areas of Autoimmune Pancreatitis and Benign Cystic Neoplasms. In addition, this edition is filled with over 500 high-quality illustrations, line drawings, and radiographs that provide a step-by-step approach to all endoscopic techniques and surgical procedures. Each of these images can be downloaded via an online image bank for use in scientific presentations. Every existing chapter in The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition has been thoroughly revised and updated to include the many changes in clinical practice since publication of the current edition. The book includes new guidelines for non-surgical and surgical treatment; new molecular biologic pathways to support clinical decision making in targeted treatment of pancreatic cancer; new minimally invasive surgical approaches for pancreatic diseases; and the latest knowledge of neuroendocrine tumors and periampullary tumors. The most encyclopedic book on the pancreas—providing outstanding and clear guidance for the practicing clinician Covers every known pancreatic disorder in detail including its anatomy, physiology, pathology, pathophysiology, diagnosis, and management Completely updated with brand new chapters Over 500 downloadable illustrations An editor and author team of high international repute who present global best-practice The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition is an important book for gastroenterologists and gastrointestinal surgeons worldwide.
Contents Contributors, Preface to the Third Edition, List of abbreviations, Section 1: Anatomy of the Pancreas 1. Development of the pancreas and related structuresBrian Lewis, Junhao Mao 2. Anatomy and the fine structure of the pancreasDaniel S. Longnecker, Fred Gorelick, Elizabeth D. Thompson 3. Congenital and inherited anomaliesMartin Zenker, Markus M. Lerch Section 2: Physiology and Pathophysiology of Pancreatic Functions 4. Physiology of acinus cell secretionOle H. Petersen 5. Physiology of duct cell secretionMei Zeng, Laura Vachel, Shmuel Muallem 6. Pathophysiology of experimental pancreatitisVikas Dudeja, Rajinder Dawra, Ashok Saluja 7. Physiology and pathophysiology of function of sphincter of OddiSavio George Barreto, James Toouli 8. Neurohormonal and hormonal control of pancreatic secretionChung Owyang 9. Regulation of pancreatic protein synthesis and growthMaria Dolors Sans, John A. Williams 10. Fibrogenesis of the pancreas: The role of stellate cellsMinoti V. Apte, Romano C. Pirola, Jeremy S. Wilson 11. Fibrogenesis of the pancreas: The role of macrophagesAida Habtezion 12. Insulo-acinar relationshipKeiko Shiratori, Kyoko Shimizu Section 3: Acute Pancreatitis 13. Epidemiology and etiology of alcohol-induced pancreatitisJeremy Wilson, Romano Pirola, Minoti Apte 14. Etiology and epidemiology of biliary acute pancreatitisMichael G. T. Raraty, Andrea Sheel, John Neoptolemos 15. Genetic factors in acute pancreatitisZachary Zator, Georgios I. Papachristou 16. The role of the intestine and the mesenteric lymph in the development of SIRS and MODS in severe acute pancreatitisAlistair B. J. Escott, Anthony R. J. Phillips, John A. Windsor 17. Neuroinflammation in acute pancreatitisJami L. Saloman, Kathryn M. Albers, Brian M. Davis 18. Molecular biochemical and metabolic abnormalities of acute pancreatitisJulia Mayerle, F. Ulrich Weiss, Walter Halangk, Markus M. Lerch 19. Histopathology of acute pancreatitisGünter Klöppel 20. Clinical classification systems of acute pancreatitisJohn A. Windsor, M. S. Petrov 21. Clinical assessment and biochemical markers to objectify severity and prognosisBettina M. Rau, Guido Alsfasser 22. Acute pancreatitis associated with congenital anomaliesChristopher R. Schlieve, Andrew L. Warshaw, Tracy C. Grikscheit 23. Acute pancreatitis in childrenMark E. Lowe, Véronique D. Morinville 24. Acute pancreatitis associated with metabolic, infections and drug-related diseasesAli A. Aghdassi, Markus M. Lerch 25. Radiologic diagnosis and staging of severe acute pancreatitisYoshihisa Tsuji Clinical course and medical treatment of acute pancreatitis (26–29) 26. Conservative therapy of acute pancreatitis: Volume substitution and enteral and parenteral nutritionTimothy B. Gardner 27. ICU treatment of severe acute pancreatitisScott R. Gunn, David C. Whitcomb 28. The use of antibiotics in severe acute pancreatitis: Indications and limitationsRainer Isenmann, Mathias Wittau 29. Indication for interventional and surgical treatment of necrotizing pancreatitisThomas E. Clancy 30. Management of infected pancreatic necroses: An endoscopic approachEduardo Rodrigues-Pinto, Todd H. Baron 31. Minimal-invasive debridement and lavage of necrotizing pancreatitisRebecca Saunders, Michael Raraty, Chris Halloran, John Neoptolemos 32. Open surgical debridement of necrotizing pancreatitisLutz Schneider, Markus W. Büchler 33. Endoscopic treatment of biliary acute pancreatitisIchiro Yasuda, Shinpei Doi, Masatoshi Mabuchi 34. Strategies of management of pseudo cysts and walled-off necroses after acute pancreatitis: Interventional endoscopic approachGeorg Beyer, Julia Mayerle, Markus M. Lerch 35. Surgical treatment of pseudo cysts and walled-off necroses after acute pancreatitisNaohiro Sata, Masaru Koizumi, Alan K. Lefor 36. Management of fluid collection in acute pancreatitisFelix Lämmerhirt, Frank Ulrich Weiss, Markus M. Lerch 37. Management of pancreatic fistula in acute pancreatitisJörg Kaiser, Thilo Hackert, Markus W. Büchler 38. Long-term outcome after acute pancreatitisChristin Tjaden, Thilo Hackert Section 4: Chronic Pancreatitis 39. Molecular understanding of chronic pancreatitisJohn F. Eisses, Sohail Z. Husain 40. Epidemiology and pathophysiology of alcoholic chronic pancreatitisAtsushi Masamune, Tooru Shimosegawa 41. Pain mechanisms in chronic pancreatitisPierluigi di Sebastiano, Tommaso Grottola, Francesco F. di Mola 42. Natural history of recurrent acute and chronic pancreatitisRohit Das, Dhiraj Yadav 43. Chronic pancreatitis with inflammatory mass in the pancreatic headUlrich F. Wellner, Tobias Keck 44. Early stage chronic pancreatitisTetsuhide Ito, Masayuki Hijioka, Tooru Shimosegawa 45. Hereditary chronic pancreatitis: Molecular pattern, clinical consequences, management principlesCeleste Shelton, David C. Whitcomb 46. Epidemiology and pathophysiology of tropical chronic pancreatitisShailesh V. Shrikhande, Savio G. Barreto 47. Cystic fibrosis (CFTR)-associated pancreatic diseaseChee Y. Ooi, Aliye Uc 48. Clinical and laboratory diagnosis of chronic pancreatitisJulia Mayerle, Peter Simon, Markus M. Lerch 49. Evidence of contrast enhanced CT and MRI/MRCPJ. Enrique Domínguez-Muñoz, Roberto García-Figueiras, Julio Iglesias-García 50. Chronic pancreatitis: Risk factors in cancerAlbert B. Lowenfels, Patrick Maisonneuve 51. Pain management of chronic pancreatitisKai Bachmann, Stephanie Plagemann, Yogesh Kumar Vashist, Jakob Robert Izbicki 52. Medical treatment of chronic pancreatitis: Pancreatic digestive enzymes: lipases, proteasesMark E. Lowe 53. Nutritional support of chronic pancreatitisSinead N. Duggan, Stephen J. O’Keefe 54. Medical treatment of chronic pancreatitis: AntioxidantsChris E. Forsmark Strategies for surgical treatment of chronic pancreatitis (55–60) 55. Evidence of endoscopic and interventional treatment of chronic pancreatitis and pseudocystsJörg Schirra, Markus M. Lerch, Julia Mayerle 56. Indications and goals of surgical treatmentRyan T. Groeschl, Michael B. Farnell 57. Pancreatic duct drainage procedureD. Bausch, Tobias Keck 58. Duodenum preserving pancreatic head resectionHans G. Beger, Bertram Poch, Yang Yinmo, Waldemar Uhl 59. Major pancreatic resectionMay C. Tee, Michael B. Farnell 60. Laparoscopic surgeryVernissia Tam, Melissa Hogg, Amer Zureikat 61. Chronic pancreatitis: Late outcome after medical and surgical treatmentVolker Aßfalg, Norbert Hüser, Helmut Friess 62. Management of pancreatic diabetes secondary to chronic pancreatitisKeiko Shiratori Section 5: Autoimmune Pancreatitis 63. Epidemiology of autoimmune pancreatitisTerumi Kamisawa, Tooru Shimosegawa 64. Pathogenesis of autoimmune pancreatitisYoh Zen 65. Histology of autoimmune pancreatitisRajib Gupta, Vikram Deshpande 66. Clinical manifestation of type 1 autoimmune pancreatitisTooru Shimosegawa, Morihisa Hirota, Atsushi Kanno 67. Clinical manifestation of type 2 autoimmune pancreatitisEmma L. Culver, George Webster 68. Laboratory diagnosis of autoimmune pancreatitisJ.-Matthias Löhr, Pia Maier, Stephan L. Haas 69. What is the evidence measuring immune markersShigeyuki Kawa 70. Imaging diagnosis of autoimmune pancreatitisKazuichi Okazaki, Tsukasa Ikeura, Kazushige Uchida, Makoto Takaoka 71. Medical treatment of autoimmune pancreatitisShounak Majumder, Suresh T. Chari 72. Long-term outcomes after treatment of autoimmune pancreatitisLuca Frulloni, Nicolò de Pretis Section 6: Neoplastic Tumors of the Exocrine Tissue: Benign Cystic Neoplasms of the Pancreas 73. Epidemiology of cystic neoplasm of the pancreasSaurabh Mukewar, Suresh Chari 74. Histologic classification and staging of cystic neoplasmNoriyoshi Fukushima, Giuseppe Zamboni 75. Molecular mechanisms of cystic neoplasmNickolas Papadopoulos, Ralph H. Hruban 76. Clinical presentation of cystic neoplasmSusumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, Kenji Yamao 77. Evaluation of cystic lesions using EUS, MRT, and CTAnne Marie Lennon, Hiroyuki Maguchi 78. Cytologic evaluation of cystic neoplasmMartha Bishop Pitman 79. Natural history of cystic neoplasm: IPMN, MCN, SCN, and SPNAnna-Katharina Stadler, Thilo Hackert, Stefan Fritz, Markus W. Büchler 80. Surveillance or surgical treatment in asymptomatic cystic neoplasmKlaus Sahora, Carlos Fernández-del Castillo Local and Standard Surgical Treatment of Cystic Neoplasms (81–85) 81. Duodenum-preserving partial or total pancreatic head resectionHans G. Beger,Bertram Poch 82. Pancreatic middle segment resection of cystic neoplasmsCalogero Iacono 83. Enucleation of cystic neoplasms: Indication and limitationRosalie A. Carr, C. Max Schmidt, Henry A. Pitt 84. Standard surgical management of IPMN, MCN, SPN, and SCN lesions: An open approachMiral Sadaria Grandhi, Barish H. Edil, Richard D. Schulick 85. Surgical treatment of cystic neoplasm: Laparoscopic approachRichard A. Burkhart, Christopher L. Wolfgang, Markus W. Büchler, Thilo Hackert 86. Management of recurrence of cystic neoplasmZhi Ven Fong, Christopher L. Wolfgang, Keith D. Lillemoe 87. Long-term outcome after observation and surgical treatment of cystic neoplasm. What is the evidence?Giovanni Marchegiani, Giuseppe Malleo, Claudio Bassi Section 7: Neoplastic Tumors of Exocrine Tissue: Pancreatic Cancer 88. Epidemiology of pancreatic cancerEvelina Mocci, Alison P. Klein 89. Smoking, a risk for pancreatic cancer: Experimental and clinical dataUwe A. Wittel, Bradley R. Hall , Surinder K. Batra 90. Molecular understanding of development of ductal pancreatic cancerLaura D. Wood, Ralph H. Hruban 91. Familial pancreatic cancerAlison P. Klein 92. Pathology of exocrine pancreatic tumorsMeredith E. Pittman, Ralph H. Hruban 93. Pancreatic cancer: Precancerous lesionsMichaël Noë, Lodewijk A. A. Brosens, Johan Offerhaus 94. Clinical history and risk factors of pancreatic cancerNorbert Hüser, Volker Aßfalg, Helmut Friess 95. Pancreatic cancer within uncinate process: Radiologic and clinical characteristicsSebastian Holländer, Dieter Birk 96. The role of EUS for diagnosis and differential diagnosis of neoplastic lesionsSusumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, Kenji Yamao 97. Radiological diagnosis of pancreatic cancer: CT, MRISiva P. Raman, Elliot K. Fishman 98. Screening of hereditary pancreatic cancerMichael Goggins 99. The role of PET in diagnosis of pancreatic cancer and cancer recurrenceNorbert Hüser, Volker Aßfalg, Isabel Rauscher, Helmut Friess 100. Tumor markers in pancreatic malignanciesShin Hamada, Atsushi Masamune, Tooru Shimosegawa 101. The role of laparoscopy and peritoneal cytology in the management of pancreatic cancerKyoichi Takaori, Shinji Uemoto 102. Clinical assessment and staging of advanced pancreatic cancerJennifer LaFemina, Ann K. Friedrich, Giles F. Whalen Surgical Treatment of Pancreatic Cancer (103–110) 103. Pancreatic cancer: Indications for resectionAkimasa Nakao 104. Pancreaticoduodenectomy for pancreatic cancer, short and long-term outcome after Kausch-Whipple and pylorus-preserving resectionJin He, John L. Cameron 105. Left pancreatectomy for body and tail cancerGeorgios Gemenetzis, Christopher L. Wolfgang 106. Total pancreatectomy: Indication and limitationsSeiko Hirono, Hiroki Yamaue 107. Laparoscopic and robotic resection for pancreatic cancerD. Magge, Herbert J. Zeh, Melissa E. Hogg 108. Extended radical surgery for pancreatic cancerThilo Hackert, Alexis Ulrich, Markus W. Büchler 109. Palliative pancreaticoduodenectomy: Benefits and limitationsChristoph W. Michalski, Max Heckler, Mert Erkan, Markus W. Büchler 110. Bypass surgery for advanced pancreatic cancerJürgen Weitz, Thomas Pausch, Christoph W. Michalski, Thilo Hackert 111. Endoscopic and interventional palliation of pancreatic cancerTakao Itoi 112. Neoadjuvant treatment of pancreatic cancer: Downstaging resultsRobert A. Wolff, Gauri Varadhachary 113. Adjuvant chemotherapy in pancreatic cancer: First line and second line treatment: Benefits of survivalRobert P. Jones, Paula Ghaneh, John P. Neoptolemos 114. Immunotherapy for pancreatic cancerAdrian G. Murphy, Elizabeth M. Jaffee, Lei Zheng 115. Targeted therapies for pancreatic cancerVincent Bernard, Anirban Maitra 116. Palliative chemotherapy for advanced pancreatic cancer: Treatment modalities, side effects and benefits of survivalOlusola O. Faluyi, Madhuchanda Chatterjee, Daniel H. Palmer 117. Management of pain in pancreatic cancerMichael Erdek 118. Role of radio and proton beam therapy for pancreatic cancerAmol K. Narang, Lauren M. Rosati, Michael D. Chuong, Joseph M. Herman 119. Management of cancer recurrenceOliver Strobel, Markus W. Büchler 120. Survival and late morbidity after resection of pancreatic cancerAvinoam Nevler, Charles J. Yeo, Jordan M. Winter Section 8: Neoplastic Tumors of the Endocrine Pancreas: Neuroendocrine Tumors of the Pancreas 121. Epidemiology and classification of neuroendocrine tumors of the pancreasJ. J. Mukherjee, Kok-Onn Lee, Gregory Kaltsas 122. Pathology of neuroendocrine tumors Atsuko Kasajima, Hironobu Sasano 123. Molecular genetic of neuroendocrine tumorsNickolas Papadopoulos, Ralph H. Hruban 124. Clinical manifestation of endocrine tumors of the pancreasKen Kawabe, Tetsuhide Ito 125. Evidence of hormonal, laboratory, biochemistric and instrumental diagnostics of neuroendocrine tumors of the pancreasKok-Onn Lee, Gregory Kaltsas, J. J. Mukherjee 126. Pancreatic neuroendocrine tumors in multiple neoplasia syndromesA. Rinke, T. M. Gress 127. Non-functioning neuroendocrine tumors: Diagnosis and management principlesTakao Ohtsuka, Hideyo Kimura, Masafumi Nakamura 128. Medical and nucleotid treatment of neuroendocrine tumors of the pancreasGregory Kaltsas, J. J. Mukherjee, Kok-Onn Lee 129. Interventional radiology treatment of neuroendocrine tumorsTakao Ohtsuka, Hideyo Kimura, Masafumi Nakamura Surgical Treatment of Endocrine Tumors of the Pancreas (130–136) 130. Enucleation of neuroendocrine tumorsHenning Dralle, Phuong Nguyen Thanh, Andreas Machens 131. Middle segment pancreatectomy and duodenum-preserving pancreatic head resection for neurendocrine tumorsHans G. Beger, Wataru Kimura 132. Major oncologic resection for neuroendocrine tumorsHenning Dralle, Phuong Nguyen Thanh, Andreas Machens 133. Management of insulinomaKeijiro Ueda, Linkaku Lee, Tetsuhide Ito 134. Gastrinoma: Evidence of medical and surgical treatmentRyuichiro Doi 135. Rare neuroendocrine tumors of the pancreas: Management and evidence of surgical treatmentRyuichiro Doi 136. Treatment of neuroendocrine tumors of the pancreas and biliary tractAndrea Frilling, Ashley K. Clift, Vito Cicinnati 137. Long-term outcome after treatment of endocrine tumorsAndreas Machens, Henning Dralle Section 9: Periampullary Tumors and others than Pancreatic Cancer 138. Periampullary tumors: Clinical presentation and diagnostic strategyAmanda Cooper, Keith D. Lillemoe 139. Histology and genetics of cancer of the papilla, distal common bile duct and duodenumYue Xue, Michelle D. Reid, Volkan Adsay 140. Adenoma and adenocarcinoma of the Ampulla of Vater: Diagnosis and managementOmer Basar, William R. Brugge 141. Endoscopic treatment of adenomas of the Ampulla of Vater: Techniques, results, benefits and limitationsNatsuyo Yamamoto, Hiroyuki Isayama, Kazuhiko Koike 142. Surgical treatment of adenoma and cancer of papilla VaterHans G. Beger, Bertram Poch, Bettina M. Rau 143. Surgical treatment of duodenal cancerFuyuhiko Motoi, Michiaki Unno 144. Surgical treatment of distal cholangiocarcinomaYukihiro Yokoyama, Tomoki Ebata, Masato Nagino 145. Adjuvant and palliative chemotherapy of periampullary cancer: First line treatment and outcomeEyas Mohamed, Paula Ghaneh, John Neoptolemos 146. Long-term survival after resection of periampullary cancerMasayuki Ohtsuka, Masaru Miyazaki Section 10: Transplantation of the Pancreas 147. Transplantation of pancreatic isletsBernhard J. Hering, Melena D. Bellin 148. Transplantation of the pancreasHans W. Sollinger, Dixon B. Kaufman Index, xxx
Hans G. Beger, MD, MD hon, Professor Emeritus of Surgery, Chairman and Head, Department of General and Visceral Surgery (1982-2002), University of Ulm, Ulm, Germany. Chairman of the German Foundation Battle Against Pancreatic Cancer. Andrew L. Warshaw, MD, FACS, W. Gerald Austen Professor of Surgery, Harvard Medical School, Surgeon-in-Chief, Chair, Department of Surgery, Massachusetts General Hospital, MA, USA. Ralph H. Hruban, MD, Director of the Sol Goldman Pancreatic Cancer Research Center and Professor of Pathology, The Johns Hopkins Hospital, Baltimore, USA. Markus W. Büchler, MD, Director of the Department of Surgery at Heidelberg University Hospital and Director of the European Pancreas Centre, Heidelberg, Germany. Markus M. Lerch, MD, Professor and Chairman, Department of Medicine, University of Greifswald, Greifswald, Germany. John P. Neoptolemos, MD, Professor of Surgery, Department of Surgery, University of Heidelberg, Heidelberg, Germany Tooru Shimosegawa, Professor of Medicine, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan. David C. Whitcomb, MD PhD, Chief, Division of Gastroenterology, Hepatology and Nutrition, Giant Eagle Foundation Professor of Cancer Genetics and Professor of Medicine, Cell Biology & Physiology and Human Genetics, University of Pittsburgh, USA.
This new updated edition of the most comprehensive reference book on pancreatic disease details the very latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known disorders. Included for the first time, are two new sections on the key areas of Autoimmune Pancreatitis and Benign Cystic Neoplasms and Neuroendocrine Tumors. In addition, this edition is filled with over 500 high-quality illustrations, line drawings, and radiographs that provide a step-by-step approach to all endoscopic techniques and surgical procedures. Each of these images can be downloaded via an online image bank for use in scientific presentations. Every existing chapter in The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition has been thoroughly revised and updated to include the many changes in clinical practice since publication of the current edition. Two thirds of the 148 chapters are new topics with the focus on new evidence-based data. The book includes new guidelines for non-surgical and surgical treatment; new molecular biologic pathways to support clinical decision making in targeted treatment of pancreatic cancer; new minimally invasive surgical approaches for pancreatic diseases; and the latest knowledge of neuroendocrine tumors and periampullary tumors. The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition is an important book for gastroenterologists and gastrointestinal surgeons worldwide.
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