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<b>List of Contributors x</b> <p><b>Foreword xiv<br /> </b><i>Robert Sapolsky</i></p> <p><b>Preface xvi</b></p> <p><b>Acknowledgments xix</b></p> <p><b>List of Abbreviations xx</b></p> <p><b>Part I Basics of the Stress Response 1</b></p> <p>1 The Basics of the Stress Response: A Historical Context and Introduction 3<br /> <i>Kenneth J. Thiel and Michael N. Dretsch</i></p> <p>2 Central Nervous System Regulation of the Hypothalamic–Pituitary–Adrenal Axis Stress Response 29<br /> <i>James P. Herman</i></p> <p>3 Corticosteroid Receptor Involvement in the Stress Response 47<br /> <i>E. Ronald de Kloet, Roel H. DeRijk, and Onno C. Meijer</i></p> <p>4 Nongenomic Cellular Actions of Corticosteroids in the Brain 76<br /> <i>Marian Joëls, Femke Groeneweg, and Henk Karst</i></p> <p>5 Stress Effects on the Brain: Intracellular Signaling Cascades, Epigenetic Mechanisms, and Implications for Behavior 95<br /> <i>Johannes M. H. M. Reul, Andrew Collins, and María Gutièrrez-Mecinas</i></p> <p>6 Mechanisms of Glucocorticoid Receptor Regulation of Gene Expression 113<br /> <i>Alyson B. Scoltock and John A. Cidlowski</i></p> <p><b>Part II Stress Influences on Brain Plasticity and Cognition 135</b></p> <p>7 Stress and Adult Neurogenesis 137<br /> <i>Timothy J. Schoenfeld and Elizabeth Gould</i></p> <p>8 Neurobiological Basis of the Complex Effects of Stress on Memory and Synaptic Plasticity 157<br /> <i>Phillip R. Zoladz, Collin R. Park, and David M. Diamond</i></p> <p>9 Acute Glucocorticoids Interact with Arousal State in Regulating Long-term Memory Formation 179<br /> <i>Patrizia Campolongo and Benno Roozendaal</i></p> <p>10 Chronic Stress Effects on Corticolimbic Morphology 201<br /> <i>Cara L. Wellman</i></p> <p>11 Effects of Chronic Stress on Memory and Neuroplasticity: Animal Studies 230<br /> <i>Carmen Sandi</i></p> <p>12 Stress and Glucocorticoid Effects on Learning and Memory: Human Studies 248<br /> <i>Marie-France Marin and Sonia J. Lupien</i></p> <p><b>Part III Stress Effects Across the Life Span 267</b></p> <p>13 Adolescence and Stress: From Hypothalamic–Pituitary–Adrenal Function to Brain Development 269<br /> <i>Russell D. Romeo and Ilia N. Karatsoreos</i></p> <p>14 Effect of Early Environment and Separation Animal Models on Neurobiological Development 285<br /> <i>Allison Jane Fulford</i></p> <p>15 Clinical Implications of Childhood Stress 304<br /> <i>Linda J. Luecken, Danielle S. Roubinov, and Catherine Purdom</i></p> <p>16 Chronic Stress and Hippocampus Vulnerability to Functional Changes and Health in the Adult 324<br /> <i>Cheryl D. Conrad</i></p> <p>17 Stress and Aging: A Question of Resilience with Implications for Disease 349<br /> <i>Erik B. Bloss, John H. Morrison, and Bruce S. McEwen</i></p> <p><b>Part IV Stress Involvement in Anxiety, Posttraumatic Stress Disorder, and Depression 367</b></p> <p>18 Social Stress Effects on Defensive Behavior and Anxiety 369<br /> <i>Brandon L. Pearson, D. Caroline Blanchard, and Robert J. Blanchard</i></p> <p>19 Stress and Animal Models of Posttraumatic Stress Disorder 388<br /> <i>Hagit Cohen, Gal Richter-Levin, and Joseph Zohar</i></p> <p>20 What Can Fear Conditioning Tell Us About Posttraumatic Stress Disorder? 410<br /> <i>Jacek Dębiec and Joseph E. LeDoux</i></p> <p>21 Stress and Glucocorticoid Effects on Memory: Implications for Anxiety Disorders 426<br /> <i>Dominique J.-F. de Quervain</i></p> <p>22 Stress and Human Neuroimaging Studies 446<br /> <i>J. Douglas Bremner</i></p> <p>23 Chronic Stress and Depression 463<br /> <i>Eberhard Fuchs and Gabriele Flügge</i></p> <p>24 How Can Stress Alter Emotional Balance Through Its Interaction with the Serotonergic System? 480<br /> <i>Raymond Mongeau, Michel Hamon, and Laurence Lanfumey</i></p> <p>25 Stress, Prefrontal Cortex Asymmetry, and Depression 505<br /> <i>Ron M. Sullivan and François Laplante</i></p> <p><b>Part V Stress, Coping, Predisposition, and Sex Differences 525</b></p> <p>26 Chronic Stress and Sex Differences on Cognition: Animal Studies 527<br /> <i>Victoria N. Luine</i></p> <p>27 Effects of Stress on Learning and Memory: Evidence for Sex Differences in Humans 545<br /> <i>Oliver T. Wolf</i></p> <p>28 Infl uence of Diet on Stress Response and Behavior 560<br /> <i>Efthymia Kitraki</i></p> <p>29 Influence of Appraisal and Coping Following Extreme Stress 578<br /> <i>Miranda Olff</i></p> <p><b>Name Index 597</b></p> <p><b>Subject Index 664</b></p>

<b>Cheryl D. Conrad</b> is Professor in the Department of Psychology and Associate Dean for Research, Division of Natural Sciences, College of Liberal Arts and Sciences, Arizona State University, Tempe. She is the author of more than 40 publications that report on how stress influences brain plasticity and resilience.<br /> <br />

<i>The Handbook of Stress</i> represents an up-to-date and authoritative guide to both the beneficial and deleterious effects of stress on brain health. Contributions from international scholars in the field emphasize actions in the brain, from the molecular and cellular stage, to systems interactions and function.<br /> <br /> <p>Sections begin with studies addressing the basics of the stress response, and proceed to examine stress influences on brain plasticity across the lifespan, including links to anxiety, PTSD, and clinical depression. Each chapter concludes with an in-depth exploration of the ways in which variables such as gender, predisposition, and coping may influence stress outcomes.</p> <p>With its breadth of coverage and cutting-edge scholarship on our current understanding of brain health, <i>The Handbook of Stress</i> is an essential resource for advanced students, professionals, and scholars at the highest level.</p>

In this timely book leading investigators have contributed comprehensive and up-to-date articles assessing current understanding of critical stress influences on brain and behavior.<br /> —<b>James L. McGaugh, University of California Irvine</b> <p>Chapters are written by leaders in their fields and the five parts of the book are well organized…it will serve admirably as an important resource for students of neuroscience, psychology, and physiology.  It will be an invaluable reference book for all libraries, as well as for those whose major interest is in this field. <br /> —<b>Mary Dallman, University of California at San Francisco</b></p>

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