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<p>Preface and Commentary vii</p> <p>List of Contributors ix</p> <p><b>Part I Biological Basis of Systems Biology 1</b></p> <p>1 Systems Biology 3<br /><i>Melanie Boerries, Roland Eils, and Hauke Busch</i></p> <p>2 Developmental Cell Biology 33<br /><i>Frank John Dye</i></p> <p>3 Principles and Applications of Embryogenomics 51<br /><i>Vincent VanBuren</i></p> <p>4 Interactome 85<br /><i>Teresa M. Przytycka and Dong-Yeon Cho</i></p> <p>5 Protein Abundance Variation 117<br /><i>Greco Hernandez and Gritta Tettweiler</i></p> <p><b>Part II Systems Biology of Evolution 143</b></p> <p>6 Genetic Variation and Molecular Darwinism 145<br /><i>Werner Arber</i></p> <p>7 Systematics and Evolution 169<br /><i>Jeffrey H. Schwartz</i></p> <p>8 Evolution of the Protein Repertoire 207<br /><i>Aaron David Goldman, Jeremy A. Horst, Ling-Hong Hung, and Ram Samudrala</i></p> <p><b>Part III Modeling of Biological Systems 237</b></p> <p>9 Chaos in Biochemistry and Physiology 239<br /><i>Miguel Antonio Aon, Sonia Cortassa, and David Lloyd</i></p> <p>10 Computational Biology 277<br /><i>Thomas Lengauer, Mario Albrecht, and Francisco S. Domingues</i></p> <p>11 Dynamics of Biomolecular Networks 349<br /><i>Emanuele Cozzo, Joaquin Sanz, and Yamir Moreno</i><br /><br />12 E-Cell: Computer Simulation of the Cell 379<br /><i>Pawan K. Dhar, Kouichi Takahashi, Yoichi Nakayama, and Masaru Tomita</i></p> <p>13 Fractals in Biology and Medicine 397<br /><i>Gabriele Angelo Losa</i></p> <p>14 Models of Cell Migration 423<br /><i>Michael Meyer-Hermann and Tilo Beyer</i></p> <p>15 Protein Modeling 469<br /><i>Marian R. Zlomislic, Valentina Corradi, and D. Peter Tieleman</i></p> <p>16 System Models for Inference on Mechanisms of Neuronal Dynamics 505<br /><i>Klaas E. Stephan and Karl J. Friston</i></p> <p>17 Systems Biology of the Liver 539<br /><i>Ian David Lockhart Bogle, Rajiv Jalan, Elizabeth Shephard, Robert Seymour, Antony Finkelstein, Thomas Sumner, and Anne Warner</i></p> <p><b>Part IV Systems Biology in Medicine and Disease 563</b></p> <p>18 Inferring Networks for Diseases 565<br /><i>Mikael Benson and Michael A. Langston</i></p> <p>19 Personalized Medicine (Predictive and Preventive) 593<br /><i>Alette M. Wessels, Robert R. Bies, and John Urquhart</i></p> <p><b>Part V Systems Biology of Organisms 625</b></p> <p>20 Microbiomes 627<br /><i>Ramana Madupu, Yu-Hui Rogers, Doug Rusch, Jason Miller, Konstantinos Krampis, and Karen E. Nelson</i></p> <p>21 Synthetic Biology: Implications and Uses 653<br /><i>Sanjay Vashee, Mikkel A. Algire, Michael G. Montague, and Michele S. Garfinkel</i></p> <p>22 Plant Systems Biology 685<br /><i>Sonia Osorio and Alisdair R. Fernie</i></p> <p>Index 699</p>

<b>Robert A. Meyers</b> obtained his Ph.D. in Chemistry at the University of California at Los Angeles. He was a post-doctoral fellow at the California Institute of Technology and has more than 17 patents, 50 technical papers and 12 books to his name. As Editor-in-Chief he conceived and edited several ambitious multivolume reference works, e.g. the <i>Encyclopedia of Analytical Chemistry</i> (Wiley), the <i>Encyclopedia of Molecular Biology and Molecular Medicine</i> (Wiley-VCH) and the <i>Encyclopedia of Physical Science and Technology</i> (Academic Press).

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