Selective Neuronal Death
Novartis Foundation Symposia, Band 126 1. Aufl.
Parkinson's disease, Alzheimer's disease, and motor neuron disease share a significant common feature: selective death of neurons in restricted regions of the brain. This international symposium, held by the Ciba Foundation in 1986, is the first to bring together neurophysiologists working on neuronal death and neuropathologists dealing with human degenerative brain disease. Participants describe the causes and sequence of events leading to neuronal death and discuss what can be done to prevent it. Among the topics covered are recent advances in the understanding of agents such as trophic factors, excitotoxins and poisons that are known to be involved in neuronal death; examples of neuronal death during normal development; and the role played by endocrine mechanisms and neuronal activity. Also considers trophic factors controlling the survival of neuronal transplants and the therapeutic prospects for tissue transplantation.
Partial table of contents: Nerve Cell Death in Degenerative Diseases of the Central Nervous System: Clinical Aspects (Y. Agid & J. Blin). Dysfunction and Death of Neurons in Human Degenerative Neurological Diseases and in Animal Models (D. L. Price, et al.). Neuronal Origin of Cerebral Amyloidogenic Proteins: Their Role in Alzheimer's Disease and Unconventional Virus Diseases of the Nervous System (C. L. Masters & K. Beyreuther). Mechanism for Programmed Cell Death in the Nervous System of a Moth (S.E. Fahrbach & J. W. Truman). Neurotrophic Factors and Neuronal Death (H. Thoenen, et al.). Muscle Activity and Motor Neuron Death in the Spinal Cord of the Chick Embryo (R. W. Oppenheim). Remodelling of Early Axonal Projections Through the Selective Elimination of Neurons and Long Axon Collaterals (D. D. M. O'Leary).
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