Details

<p>Contributors ix</p> <p>Foreword xvii</p> <p>Preface xix</p> <p>Abbreviations xxi</p> <p><b>Part I Fluorine-18 Labeled Radiopharmaceuticals 1</b></p> <p>1. Synthesis of [¹⁸F]-Fluorodeoxyglucose ([¹⁸F]FDG) 3<br /><i>Michelle L. Richards and Peter J. H. Scott</i></p> <p>2. Synthesis of Sodium [¹⁸F]Fluoride (Na[¹⁸F]F) 15<br /><i>Brian G. Hockley and Peter J. H. Scott</i></p> <p>3. Radiosynthesis of 3_-Deoxy-3_-[¹⁸F]Fluorothymidine ([¹⁸F]FLT) 21<br /><i>Hartmuth C. Kolb, Henry C. Padgett, Steve Zigler, Jim Patanella, Fanrong Mu, Umesh B. Gangadharmath, Vani P. Mocharla, Peter J. H. Scott, and Joseph C. Walsh</i></p> <p>4. Synthesis of [¹⁸F]Fluoroazomycin Arabinoside ([¹⁸F]FAZA) 31<br /><i>Brian G. Hockley and Peter J. H. Scott</i></p> <p>5. Synthesis of [¹⁸F]Fluoromisonidazole (1-(2-Hydroxy-3-[¹⁸F]Fluoropropyl)-2-Nitroimidazole, [¹⁸F]FMISO) 41<br /><i>Patrick J. Riss, Valentina Ferrari, Robert Bielik, Roberto Canales-Candela, Rob Smith, and Franklin I. Aigbirhio</i></p> <p>6. Synthesis of [¹⁸F]FPPRGD2 51<br /><i>Shuanglong Liu, Frederick T. Chin, Zhen Cheng, and Xiaoyuan Chen</i></p> <p>7. Synthesis of [¹⁸F]Fluorocholine ([¹⁸F]FCH) 61<br /><i>David Kryza</i></p> <p>8. Clinical Manufacturing of [¹⁸F]-16-<i>α</i>-Fluoroestradiol ([¹⁸F]FES) 69<br /><i>Piyush Kumar and John R. Mercer</i></p> <p>9. Synthesis of <i>N</i>-Succinimidyl 4-[¹⁸F]Fluorobenzoate ([¹⁸F]SFB) 81<br /><i>Xia Shao</i></p> <p>10. Synthesis of 4-(2_-Methoxyphenyl)-1-[2_-(<i>N</i>-2__Pyridinyl)-<i>p</i>-[¹⁸F]Fluorobenzamido]Ethylpiperazine [¹⁸F]MPPF 87<br /><i>Marion Alvarez and Didier Le Bars</i></p> <p>11. Synthesis of [¹⁸F]-Fallypride 95<br /><i>Laurent Brichard, Valentina Ferrari, Rob Smith, and Franklin I. Aigbirhio</i></p> <p>12. Synthesis of [¹⁸F]Fluoroethyltyrosine (¹⁸F-FET) 103<br /><i>Yi Zhao, Amar Alfteimi, and Maaz Zuhayra</i></p> <p>13. Synthesis of [¹⁸F]Flumazenil ([¹⁸F]FZ) 111<br /><i>Ralf Schirrmacher, Alexey Kostikov, Gassan Massaweh, Miriam Kovacevic, Carmen Wängler, and Alexander Thiel</i></p> <p>14. Synthesis of 6-[¹⁸F]Fluorodopamine (6-[¹⁸F]FDA) 125<br /><i>Michael A. Channing, John L. Musachio, and Jozef J. Kusmierz</i></p> <p>15. Synthesis of 2-([¹⁸F]Fluoro)-3-[(2<i>S</i>)-2-Azetidinylmethoxy]Pyridine ([¹⁸F]2FA) 139<br /><i>Hayden T. Ravert, Daniel P. Holt, and Robert F. Dannals</i></p> <p>16. Synthesis of [¹⁸F]-Substance-P Antagonist-Receptor Quantifier ([¹⁸F]SPA-RQ) 155<br /><i>Sofie Celen, Kim Serdons, Tjibbe de Groot, Terence G. Hamill, and Guy Bormans</i></p> <p><b>Part II</b> <b>Carbon-11 Labeled Radiopharmaceuticals </b><b>167</b></p> <p>17. Synthesis of [¹¹C]Choline Chloride ([¹¹C]CHL) 169<br /><i>Brian G. Hockley, Bradford Henderson, and Xia Shao</i></p> <p>18. Synthesis of 2-(4-<i>N</i>-[¹¹C]Methylaminophenyl)-6-Hydroxybenzothiazole ([¹¹C]6-OH-BTA-1; [¹¹C]PIB) 177<br /><i>Cécile Philippe, Markus Mitterhauser, and Wolfgang Wadsak</i></p> <p>19. Synthesis of [¹¹C]-meta-Hydroxyephedrine ([¹¹C]MHED) 191<br /><i>Filippo Lodi, Assunta Carpinelli, Claudio Malizia, and Stefano Boschi</i></p> <p>20. Synthesis of l-[methyl-¹¹C]Methionine ([¹¹C]MET) 199<br /><i>Amy L. Vāvere and Scott E. Snyder</i></p> <p>21. Synthesis of (+)-<i>α</i>-[¹¹C]Dihydrotetrabenazine ([¹¹C]DTBZ) 213<br /><i>Michael R. Kilbourn</i></p> <p>22. Synthesis of [¹¹C]Flumazenil([¹¹C]FMZ) 221<br /><i>Roberto Canales-Candela, Patrick J. Riss, and Franklin I. Aigbirhio</i></p> <p>23. Synthesis of [¹¹C]Hexadecanoic Acid ([¹¹C]Palmitic Acid) 233<br /><i>Adam C. Runkle, Xia Shao, and Peter J. H. Scott</i></p> <p>24. Synthesis of <i>O</i>-methyl-¹¹C]Metomidate ([¹¹C]-MTO) 245<br /><i>István Boros and Franklin I. Aigbirhio</i></p> <p>25. Synthesis of [¹¹C]Carfentanil ([¹¹C]CFN) 257<br /><i>Louis Tluczek and Xia Shao</i></p> <p>26. Synthesis of [carbonyl-¹¹C]Way-100635 265<br /><i>Jan D. Andersson, Sangram Nag, Raisa N. Krasikova, Victor W. Pike, and Christer Halldin</i></p> <p>27. Synthesis of [¹¹C]Raclopride 275<br /><i>Xia Shao</i></p> <p>28. Synthesis of 3-Amino-4-[2-(<i>N</i>-Methyl-<i>N</i>-[¹¹C]Methyl-Amino-Methyl)Phenylsulfanyl]-Benzonitrile ([¹¹C]Dasb) 285<br /><i>Daniela Haeusler, Markus Mitterhauser, and Wolfgang Wadsak</i></p> <p>29. Synthesis of [¹¹C] Acetate 297<br /><i>Filippo Lodi, Claudio Malizia, and Stefano Boschi</i></p> <p>30. Synthesis of <i>N</i>-(2-[¹¹C]Methoxybenzyl)-<i>N</i>-(4-Phenoxypyridin-3-yl)Acetamide ([¹¹C]PBR28) 305<br /><i>Qi-Huang Zheng, Min Wang, and Bruce H. Mock</i></p> <p><b>Part III Other Radiopharmaceuticals 313</b></p> <p>31. Synthesis of [¹³N]Ammonia ([¹³N]NH₃) 315<br /><i>Peter J. H. Scott</i></p> <p>32. Synthesis of [⁶⁸GA]Gallium Dota-(TYR³)-Octreotide Acetate ([⁶⁸GA]-Dotatoc) 321<br /><i>Harald Eidherr, Friedrich Girschele, Markus Mitterhauser, and Wolfgang Wadsak</i></p> <p>Appendix 1 Supplier Information 335</p> <p>Index 339</p>

<b>Peter J. H. Scott</b> is an Assistant Professor in the Department of Radiology at the University of Michigan Medical School. Dr. Scott edited <i>Linker Strategies in Solid-phase Organic Synthesis</i> (also from Wiley) and is the series editor for the Wiley Series on <i>Solid Phase Organic Syntheses</i>. <p><b>Brian G. Hockley</b> is Radiopharmaceutical Quality Manager at the University of Michigan Medical School, where he works with Michael Kilbourn on radiopharmaceutical research and development. Mr. Hockley has co-authored several articles and a chapter in <i>Linker Strategies in Solid-phase Organic Synthesis</i> (also from Wiley).</p>

<b>The ultimate reference guide to the synthesis of radiopharmaceuticals</b> <p>The <i>Radiochemical Syntheses</i> series provides scientists and professionals with a comprehensive reference to proven synthetic methods for radiochemical reactions, along with step-by-step guidance on how to replicate these syntheses in the laboratory.</p> <p>Volume 1 in the series focuses on the synthesis and purification of radiopharmaceuticals in clinical use today. It brings together in one complete, self-contained volume a collection of monographs containing a wealth of practical information from across the literature, demonstrating in meticulous detail how to prepare radiopharmaceuticals for positron emission tomography (PET) imaging, especially in tumor studies, cardiology, and neuroscience.</p> <p>Readers have key experimental details culled from the literature at their fingertips, greatly simplifying the process of qualifying a site for the clinical production of new radiopharmaceuticals.</p>

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