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Library of Congress Cataloging-in-Publication Data applied for.
ISBN: 9781119004882
Cover inset figure: Courtesy of Maude Guillier.
Regulation of gene expression in bacteria plays a key role in their adaptation to ever-changing environments. Transcription is the first level of control that has been described and decades of research have led to a thorough characterization of the transcriptional network, at least for some of the model bacteria such as Escherichia coli. However, it is now clear that many genes are subject to post-transcriptional control as well, and small RNAs are a major class of post-transcriptional regulators. Many functions are in fact controlled by mixed regulatory circuits encompassing both transcriptional and post-transcriptional control mediated respectively by proteins or RNAs. The properties of such circuits are just starting to be elucidated. In the regulatory scheme shown on the cover, the involvement of Hfq-binding sRNAs in control of motility and adhesion in enterobacteria is depicted. Positive and negative controls are shown with normal and blunt-end arrows respectively. Asterisks indicate regulatory interactions presumed to be direct. Green triangles highlight feedforward regulatory motifs. The regulatory scheme is found in Figure 5.1.1 in Chapter 5.1 by Maude Guillier et al. For more details see Chapter 5.1.
This work is dedicated to my wife, Cathy Senta-Loys de Bruijn, for her support and interest in the book, and her love and understanding during the hectic editing episodes.