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Contents

Associate Editors

Paulette M. Gillig

Professor of Psychiatry and Director of Rural Psychiatry Division

Department of Psychiatry

Wright State University Boonshoft School of Medicine

Dayton, OH

USA

Eric R. Kandel

University Professor, Neuroscience, Psychiatry, Physiology and Cellular Biophysics, Biochemistry and Molecular Physics

Fred Kavli Professor and Director, Kavli Institute for Brain Science

Senior Investigator, Howard Hughes Medical Institute

Columbia University College of Physicians and Surgeons

New York, NY

USA

David A. Mrazek

Professor of Psychiatry

Department of Psychiatry and Psychology

Mayo Clinic

Rochester, MN

USA

H. Jonathan Polan

Adjunct Associate Professor of Clinical Psychiatry

Department of Psychiatry

Columbia University College of Physicians and Surgeons

New York, NY

USA

Michelle B. Riba

Clinical Professor

Department of Psychiatry

University of Michigan

Ann Arbor, MI

USA

Steven P. Roose

Professor of Clinical Psychiatry

Department of Psychiatry

Columbia University College of Physicians and Surgeons

New York, NY

USA

Bruce J. Rounsaville

Professor of Psychiatry

Director of Research, Division of Substance Abuse

Department of Psychiatry

Yale University

New Haven, CT

Director, Veterans’ Affairs Connecticut Healthcare Center

West Haven, CT

USA

Andrew E. Skodol

Professor of Clinical Psychiatry

Department of Psychiatry

Columbia University College of Physicians and Surgeons

New York, NY

USA

William H. Sledge

George D. and Esther S. Gross Professor of Psychiatry Department of Psychiatry

Yale University

Medical Director, Yale-New Haven Psychiatric Hospital

New Haven, CT

USA

Robert J. Ursano

Professor of Psychiatry and Neuroscience

Center for Traumatic Stress

Chair, Department of Psychiatry

Uniformed Services University of the Health Sciences

Bethesda, MD

USA

Assistant Editor

Melissa Arbuckle

Assistant Professor of Clinical Psychiatry

Department of Psychiatry

Columbia University College of Physicians and Surgeons

New York, NY

USA

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Dedications

With love and thanks to Cathy, Joshua, David and Sarah and to my parents, Goodie and Zelda, for your love and support.

Allan

To my wife Rena, to my children Sarah, Rachel and Jonathan, and to my mother Miriam, for their enduring love and support.

Jerry

To my father Howard (RIP) and mother Ruth who inspired me; and to my wife Rosemarie and sons Jonathan and Jeremy who supported me then and now.

Jeffrey

To my wife, Leslee, and my parents, David and Reda, for all of your love and support.

Michael

To my wife Piera, my son Federico and my parents Federico and Olga for their love and support.

Mario

Volume 1

Contributors

Anissa Abi-Dargham

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Henry D. Abraham

Department of Psychiatry, Harvard Medical School, Waltham, MA, USA

Adekunle G. Ahmed

University of Ottawa, Ottawa, Ontario, Canada

David G. Amaral

Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA, USA

Dima Amso

Department of Psychiatry, Weill Medical College of Cornell University, New York, NY, USA

Sonia Ancoli-Israel

Department of Psychiatry, University of California, San Diego, CA, USA

Department of Veterans Affairs, San Diego Healthcare System, San Diego, CA, USA

Jules Angst

Zurich University Psychiatric Hospital, Zurich, Switzerland

Martin M. Antony

Department of Psychology, Ryerson University, Toronto, ON, Canada

Gordon J. G. Asmundson

University of Regina, Regina, Saskatchewan, Canada

Thomas F. Babor

Department of Community Medicine and Health Care, University of Connecticut School of Medicine, Farmington, CT, USA

Thomas C. Baghai

Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Munich, Germany

Jennifer R. Baker

Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA

Mark S. Bauer

VA Boston Healthcare System, Boston, MA, USA

William R. Beardslee

Department of Psychiatry, Children’s Hospital Boston, Boston, MA, USA

Department of Psychiatry, Harvard Medical School, Boston, MA, USA

Fred Beauvais

Department of Psychology, Colorado State University, Fort Collins, CO, USA

Jean C. Beckham

Department of Psychiatry and

Behavioral Sciences, Duke University Medical Center, Durham, NC, USA

Alan S. Bellack

VISN 5 Mental Illness Research, Education, and Clinical Center, University of Maryland School of Medicine, Baltimore, MD, USA

Donna S. Bender

Institute for Mental Health Research, Phoenix, AZ, USA

David M. Benedek

Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

Kathy R. Berenson

Department of Psychology, Columbia University, New York, NY, USA

Heather Berlin

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

Ellen Berman

Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA

David Bienenfeld

Department of Psychiatry, Wright State University Boonshoft School of Medicine, Dayton, OH, USA

William V. Bobo

Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA

Robert J. Boland

Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA

Neil W. Boris

Department of Psychiatry and Neurology, Tulane University Health Sciences Center, New Orleans, LA, USA

Department of Community Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA

Alan Breier

Eli Lilly and Company, Lilly Corporate Center, IN, USA

Evelyn J. Bromet

Departments of Psychiatry and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA

Timothy A. Brown

Center for Anxiety Related Disorders, Boston University, Boston, MA, USA

Richard P. Brown

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Gerard E. Bruder

Department of Psychology, Columbia University College of Physicians and Surgeons, New York, NY, USA

Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY, USA

Rachel J. Bryant-Waugh

Department of Child and Adolescent Mental Health, Great Ormond Street Hospital NHS Trust, London, UK

Robert P. Cabaj

San Francisco Community Behavioral Health Services, San Francisco, CA, USA

Deborah L. Cabaniss

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

New York State Psychiatric Institute, New York, NY, USA

Joseph R. Calabrese

Department of Psychiatry, Case Western Reserve University and University Hospitals, Cleveland, OH, USA

David A. Casey

Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, USA

Kenneth Certa

Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA, USA

Chia-Hui Chen

Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Taipei, Taiwan

Cezar Cimpeanu

Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA

John F. Clarkin

Weill Cornell Medical College, New York Presbyterian Hospital, White Plains, NY, USA

Keith H. Claypoole

Department of Psychology, University of Hawaii, Manoa, HI, USA

Robert B. Clyman

Kempe Center for the Prevention and Treatment of Child Abuse and Neglect, University of Colorado School of Medicine, Denver, CO, USA

Arnold M. Cooper

Department of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY, USA

Francine Cournos

New York State Psychiatric Institute, New York, NY, USA

Sara W. Cullen

School of Social Policy and Practice, University of Pennsylvania, Philadelphia, PA, USA

Jonathan R. T. Davidson

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA

Paul Desan

Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA

Mantosh J. Dewan

Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, NY, USA

Darin D. Dougherty

Department of Psychiatry,

Massachusetts General Hospital, Boston, MA, USA

Geraldine Downey

Department of Psychology, Columbia University, New York, NY, USA

Ronald Duman

Department of Psychiatry, Yale University, New Haven, CT, USA

Jonathan E. Dunn

San Francisco Psychoanalytic Institute, San Francisco, CA, USA

Deidre M. Edwards

Department of Psychiatry, Division of Psychology, University of Texas Southwestern Medical Center, Dallas, TX, USA

Jane L. Eisen

Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI, USA

Butler Hospital, Providence, RI, USA

Stuart J. Eisendrath

Department of Psychiatry, University of California, San Francisco, CA, USA

Rif S. El-Mallakh

Department of Psychiatry, University of Louisville School of Medicine, Louisville, KY, USA

Richard S. Epstein

F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

Milton Erman

Department of Psychiatry, University of California, San Diego, CA, USA

Avastra USA, Inc., Laguna Hills, CA, USA

Amit Etkin

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA

Kelly N. Fahl

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Ayman Fanous

Department of Psychiatry, Washington VA Medical Center, Washington, DC, USA

Hossein Fatemi

Department of Psychiatry, University of Minnesota School of Medicine, Minneapolis, MN, USA

John P. Fedoroff

University of Ottawa, Ottawa, Ontario, Canada

Morgan Feibelman

Department of Psychiatry and Neurology, Tulane University School of Medicine, New Orleans, LA, USA

Alan D. Felix

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Project Reachout, Goddard-Riverside Community Center, New York, NY, USA

Susan J. Fiester

Bethesda, MD, USA

W. Wolfgang Fleischacker

Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria

Michael B. First

Department of Psychiatry, Columbia University Medical Center, New York, NY, USA

New York State Psychiatric Institute, New York, NY, USA

Anne M. Fleming

Department of Psychiatry, University of California, San Francisco, CA, USA

Amanda M. Flood

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA

Peter Fonagy

UCL Psychoanalysis Unit, University College London, London, UK

Lisa Maria E. Frantsve

Psychology Service, VA Connecticut Healthcare System, West Haven, CT, USA

Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA

Edward S. Friedman

Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

Sandra L. Friedman

Division of Developmental Medicine, Harvard Medical School, Boston, MA, USA

Robert L. Frierson

Department of Psychiatry, University of Louisville School of Medicine, Louisville, KY, USA

Paul J. Fudala

Reckitt Benckiser Pharmaceuticals Inc., Richmond, VA, USA

Andrew C. Furman

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA

Emory University Psychoanalytic Institute, Atlanta, GA, USA

Robert M. Galatzer-Levy

Chicago Psychoanalytic Institute, Chicago, IL, USA

Patricia L. Gerbarg

Department of Psychiatry, New York Medical College, Valhalla, NY, USA

Paulette Marie Gillig

Department of Psychiatry, Wright State University Boonshoft School of Medicine, Dayton, OH, USA

Sybil A. Ginsburg

Emory University Psychoanalytic Institute, Atlanta, GA, USA

Anthony J. Giuliano

Department of Psychiatry, Harvard Medical School, Boston, MA, USA

Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, MA, USA

Ira D. Glick

Department of Psychiatry and Bchavior Sciences, Stanford School of Medicine, Stanford, CA, USA

Roger P. Greenberg

Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, NY, USA

Laurence L. Greenhill

Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, NY, USA

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Stanley I. Greenspan

Interdisciplinary Council for Developmental and Learning Disorders, George Washington University Medical School, Bethesda, MD, USA

Department of Psychiatry and Pediatrics, George Washington University Medical School, Bethesda, MD, USA

Thomas A. Grieger

Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

James L. Griffith

Department of Psychiatry and Behavioral Sciences, The George Washington University School of Medicine, Washington, DC, USA

Roland R. Griffiths

Departments of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Heinz Grunze

School of Neurology, Neurobiology, and Psychiatry, Newcastle University, Newcastle-upon-Tyne, UK

Jaswant Guzder

Division of Social and Transcultural Psychiatry, McGill University, Montreal, Quebec, Canada

Patrick J. Haggard

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA

Emory University Psychoanalytic Institute, Atlanta, GA, USA

Kathryn L. Hale

Department of Psychiatry, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Jeffrey M. Halperin

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

Department of Psychology, Queens College of the City University of New York, New York, NY, USA

John H. Halpern

Department of Psychiatry, McLean Hospital, Belmont, MA, USA

Derrick A. Hamaoka

Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

John Hardy

Laboratory of Neurogenetics, National Institutes of Health, Bethesda, MD, USA

Carlos A. Hernandez-Avila

Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA

Ralph E. Hoffman

Yale-New Haven Psychiatric Hospital, New Haven, CT, USA

Michael F. Hogan

New York State Office of Mental Health, Albany, NY, USA

Kevin Ann Huckshorn

National Association of State Mental Hospital Program Directors,

Alexandria, VA, USA

Lawrence B. Inderbitzen

Emory University Psychoanalytic Institute, Atlanta, GA, USA

Zahinoor Ismail

Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

Iliyan Ivanov

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

Mark E. James

Emory University Psychoanalytic Institute, Atlanta, GA, USA

James M. Jaranson

Department of Psychiatry, University of Minnesota, MN, USA

G. Eric Jarvis

Division of Social and Transcultural Psychiatry, McGill University, Montreal, Quebec, Canada

Daniel C. Javitt

Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA

Dilip V. Jeste

Department of Psychiatry, University of California, San Diego, CA, USA

San Diego VA Healthcare System, San Diego, CA, USA

Charles Y. Jin

Department of Psychiatry, New York University School of Medicine, New York, NY, USA

Denise Kandel

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

New York State Psychiatric Institute, New York, NY, USA

Maria Karayiorgou

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Marianne C. Kastrup

Centre Transcultural Psychiatry, Copenhagen University Hospital, Denmark

Abigail Kay

Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA, USA

Jerald Kay

Department of Psychiatry, Wright State University Boonshoft School of Medicine, Dayton, OH, USA

Rena L. Kay

Department of Psychiatry, Wright State University Boonshoft School of Medicine, Dayton, OH, USA

Courtney Pierce Keeton

Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD, USA

Martin B. Keller

Department of Psychiatry and Human Behavior, Brown University,

Providence, RI, USA

David E. Kemp

Department of Psychiatry, Case Western Reserve University and University Hospitals, Cleveland, OH, USA

Robert D. Kerns

Psychology Service, VA Connecticut Healthcare System, West Haven, CT, USA

Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA

Ronald C. Kessler

Department of Health Care Policy, Harvard Medical School, Boston, MA, USA

Helen G. Kim

Department of Psychiatry, Hennepin County Medical Center, Minneapolis, MN, USA

Laurence J. Kirmayer

Division of Social and Transcultural Psychiatry, McGill University, Montreal, Quebec, Canada

Ami Klin

Yale Child Study Center, New Haven, CT, USA

Kim Klipstein

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

William M. Klykylo

Department of Psychiatry, Wright State University Boonshoft School of Medicine, Dayton, OH, USA

Robert Kohn

Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA

George F. Koob

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA

Susan G. Kornstein

Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, VA, USA

Thomas R. Kosten

Department of Psychiatry and Neuroscience, Baylor College of Medicine, Houston, TX, USA

Amy E. Lawrence

Center for Anxiety Related Disorders, Boston University, Boston, MA, USA

Joseph E. LeDoux

Center for Neural Science, New York University, New York, NY, USA

Harriet P. Lefley

Department of Psychiatry and

Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA

Douglas S. Lehrer

Department of Psychiatry, Wright State University Boonshoft School of Medicine, Dayton, OH, USA

James L. Levenson

Department of Psychiatry, Virginia Commonwealth University,

Richmond, VA, USA

Frances R. Levin

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

New York State Psychiatric Institute, New York, NY, USA

Stephen B. Levine

Department of Psychiatry, Case Western Reserve School of Medicine, Beachwood, OH, USA

Steven T. Levy

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA

Emory University Psychoanalytic Institute, Atlanta, GA, USA

Roberto Lewis-Fernández

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Jeffrey A. Lieberman

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

New York State Psychiatric Institute, New York, NY, USA

Michael L. Liebowitz

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

New York State Psychiatric Institute, New York, NY, USA

Keh-Ming Lin

Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Taipei, Taiwan

Margaret T. Lin

Southern California Permanente Medical Group, Downey, CA, USA

Walter Ling

David Geffen School of Medicine, University of California, Los Angeles, CA, USA

Sarah H. Lisanby

New York State Psychiatric Institute, New York, NY, USA

David A. Lowenthal

New York State Psychiatric Institute, New York, NY, USA

Christopher P. Lucas

Department of Child and Adolescent Psychiatry, New York University School of Medicine, New York, NY, USA

Rachel E. Maddux

Department of Psychology, Lund University, Lund, Sweden

José R. Maldonado

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Standford, CA, USA

Stephen R. Marder

Semel Institute for Neuroscience, University of California, Los Angeles, CA, USA

John C. Markowitz

New York State Psychiatric Institute, New York, NY, USA

Kim J. Masters

College of Health Professions, Medical University of South Carolina, Charleston, SC, USA

Randi E. McCabe

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada

Elinore F. McCance-Katz

Department of Psychiatry, University of California, San Francisco, CA, USA

Thomas H. McGlashan

Yale Psychiatric Institute, Yale University, New Haven, CT, USA

Patrick J. McGrath

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

James McPartland

Yale Child Study Center, New Haven, CT, USA

Hunter L. McQuistion

Division of Integrated Psychiatric Services, St Luke’s and Roosevelt Hospitals, New York, NY, USA

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Michael J. Meaney

Douglas Hospital Research Center, Montreal, Quebec, Canada

Thomas W. Meeks

Department of Psychiatry, University of California, San Diego, CA, USA

Herbert Y. Meltzer

Division of Psychopharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA

Glenn A. Melvin

New York State Psychiatric Institute, New York, NY, USA

Kathleen R. Merikangas

National Institute of Mental Health, National Institutes of Health,

Bethesda, MD, USA

David B. Merrill

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

New York State Psychiatric Institute, New York, NY, USA

Juan E. Mezzich

International Center for Mental Health and Division of Psychiatric Epidemiology, Mount Sinai School of Medicine of New York University, New York, NY, USA

David J. Miklowitz

Department of Psychology, University of Colorado, Boulder, CO, USA

Jeffrey M. Miller

New York State Psychiatric Institute, New York, NY, USA

Elsa G. E. Mirasol

Department of Psychiatry, Columbia University Medical Center, Presbyterian Hospital, New York, NY, USA

Seiya Miyamoto

Department of Neuropsychiatry, St. Marianna University School of Medicine, Kawasaki, Japan

Paul C. Mohl

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA

Wanda K. Mohr

Psychiatric Mental Health Nursing, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA

Holly M. Moore

New York State Psychiatric Institute, New York, NY, USA

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

David P. Moore

Frazier Rehab Institute, Louisville, KY, USA

Ann K. Morrison

Department of Psychiatry, Wright State University Boonshoft School of Medicine, Dayton, OH, USA

David A. Mrazek

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA

Stephanie N. Mullins-Sweatt

Department of Psychology, University of Kentucky, Lexington, KY, USA

Kerim M. Munir

Division of Developmental Medicine and Department of Psychiatry, Harvard Medical School, Boston, MA, USA

Philip R. Muskin

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

David J. Muzina

Department of Psychiatry and Psychology, Cleveland Clinic Neurological Institute, Cleveland, OH, USA

J. Craig Nelson

Department of Psychiatry, University of California, San Francisco, CA, USA

David N. Neubauer

Psychiatry Mobile Treatment Services, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA

Jeffrey H. Newcorn

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

Benjamin R. Nordstrom

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

New York State Psychiatric Institute, New York, NY, USA

Edward V. Nunes

New York State Psychiatric Institute, New York, NY, USA

Ahmed Okasha

WHO Collaborating Center for Research and Training in Mental Health, Ain Shams University, Cairo, Egypt

John M. Oldham

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA

Maria A. Oquendo

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

New York State Psychiatric Institute, New York, NY, USA

Brooke S. Parish

Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA

Jayendra K. Patel

Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA

Michele T. Pato

Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Natalya Paykina

Division of Child and Adolescent Psychiatry, New York State

Psychiatric Institute, New York, NY, USA

Teri Pearlstein

Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI, USA

Women’s Behavioral Health Program, Women and Infants Hospital, Providence, RI, USA

Katharine A. Phillips

Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI, USA

Butler Hospital, Providence, RI, USA

Emma H. C. Piepenstock

Department of Child and Adolescent Mental Health, Great Ormond Street Hospital NHS Trust, London, UK

Debra A. Pinals

Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA

Christopher Pittenger

Department of Psychiatry, Yale University, New Haven, CT, USA

H. Jonathan Polan

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Bruce G. Pollock

Division of Geriatric Psychiatry, University of Toronto, Toronto, Ontario, Canada

Kelly Posner

New York State Psychiatric Institute, New York, NY, USA

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Wilfrid Noel Raby

New York State Psychiatric Institute, New York, NY, USA

Mark Hyman Rapaport

Department of Psychiatry, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Department of Psychiatry, University of California, Los Angeles, CA, USA

Judith L. Rapoport

National Institutes of Mental Health, Bethesda, MD, USA

Scott L. Rauch

McLean Hospital, Belmont, MA, USA

Nancy Raymond

Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA

Chad J. Reissig

Departments of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Arnold D. Richards

New York Psychoanalytic Institute, New York, NY, USA

Stephanie A. Riolo

Department of Psychiatry, Wright State University Boonshoft School of Medicine, Dayton, OH, USA

Eva Ritvo

Department of Psychiatry, Mount Sinai Medical Center, Miami, FL, USA

Trevor W. Robbins

Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK

Sally J. Rogers

Department of Psychiatry and

Behavioral Sciences, University of California, Davis, CA, USA

Steven P. Roose

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Neil Rosenberg

Division of Neuroscience and Behavioral Research, NIDA, Bethesda, MD, USA

Erik J. Roskes

Forensic Treatment and Correctional Services, Springfield Hospital Center, Sykesville, MD, USA

Ralph E. Roughton

Emory University Psychoanalytic Institute, Atlanta, GA, USA

Cécile Rousseau

Division of Social and Transcultural Psychiatry, McGill University, Montreal, Quebec, Canada

Stefan Rowny

Department of Psychiatry, Columbia University, New York, NY, USA

John L. R. Rubenstein

Department of Psychiatry, University of California, San Francisco, CA, USA

Maria Angeles Ruiperez

Department of Basic and Clinical Psychology and Psychobiology, Jaume I University, Castellon, Spain

Bret R. Rutherford

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Sanjay Sabnani

Hythiam, Inc., Los Angeles, CA, USA

Fabian M. Saleh

UMass Memorial Medical Center, Worcester, MA, USA

Judith Samuels

Department of Child and Adolescent Psychiatry, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA

Department of Psychiatry, New York University School of Medicine, New York, NY, USA

Richard D. Sanders

Departments of Psychiatry and Neurology, Wright State University Boonshoft School of Medicine, Dayton, OH, USA

Dayton VA Medical Center, Dayton, OH, USA

Alan Schatzberg

Department of Psychiatry, Stanford University, Stanford, CA, USA

Michael Scheeringa

Institute of Infant and Early Childhood Mental Health, Tulane University Health Sciences Center, New Orleans, LA, USA

Lon S. Schneider

Department of Psychiatry and Behavioral Sciences, University of Southern California School of Medicine, Los Angeles, CA, USA

Cornelius Schüle

Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Munich, Germany

Kurt Schulz

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

Beth Seelig

Emory University Psychoanalytic Institute, Atlanta, GA, USA

Larry J. Seidman

Department of Psychiatry, Harvard Medical School, Boston, MA, USA

Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, MA, USA

Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA

Kevin A. Sevarino

Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA

David Shaffer

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Division of Child and Adolescent Psychiatry, Columbia University Medical Center, New York, NY, USA

Theodore Shapiro

Department of Psychiatry, Weill Medical College of Cornell University, New York, NY, USA

Vanshdeep Sharma

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

Charles W. Sharp

Division of Neuroscience and Behavioral Reasearch, NIDA, Bethesda, MD, USA

M. Katherine Shear

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

John E. Showalter

Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA

Edward K. Silberman

Department of Psychiatry, Tufts University, Boston, MA, USA

Larry B. Silver

Department of Psychiatry, Georgetown University Medical Center, Washington, DC, USA

Daphne Simeon

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

Andrew E. Skodol

Institute for Mental Health Research, Phoenix, AZ, USA

William H. Sledge

Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA

Lois Slovik

Massachusetts General Hospital and Harvard Medical School, Newton, MA, USA

Scott A. Small

Department of Neurology, Columbia University, New York, NY, USA

David E. Smith

San Francisco Prometa Center, San Francisco, CA, USA

Henry F. Smith

Psychoanalytic Institute of New England, Boston, MA, USA

Michael W. Smith

Department of Psychiatry, HarborUniversity of California Research Institute, Torrance, CA, USA

Phyllis Solomon

School of Social Policy and Practice, University of Pennsylvania, Philadelphia, PA, USA

Stephen M. Sonnenberg

Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

Matt W. Specht

Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD, USA

David Spiegel

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine,

Standford, CA, USA

Margaret Spinelli

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

New York State Psychiatric Institute, New York, NY, USA

Brian Stafford

Institute of Infant and Early Childhood Mental Health, Tulane University Health Sciences Center, New Orleans, LA, USA

Departments of Psychiatry and Pediatrics, University of Colorado Health Sciences Center, Denver, CO, USA

Barbara H. Stanley

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

John Jay College of Criminal Justice, City University of New York, New York, NY, USA

New York State Psychiatric Institute, New York, NY, USA

Brett N. Steenbarger

Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, NY, USA

Marc L. Steinberg

Department of Psychiatry, Robert Wood Johnson Medical School, New Brunswick, NJ, USA

Donna E. Stewart

University Health Network, University of Toronto, Toronto, Ontario, Canada

Michael H. Stone

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Walter N. Stone

Department of Psychiatry, University of Cincinnati, OH, USA

James J. Strain

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

Ludwik S. Szymanski

Division of Developmental Medicine and Department of Psychiatry, Harvard Medical School, Boston, MA, USA

Pierre N. Tariot

Banner Alzheimer’s Institute, Arizona Alzheimer’s Consortium, Phoenix, AZ, USA

Department of Psychiatry, University of Arizona College of Medicine, Phoenix, AZ, USA

Steven Taylor

University of British Columbia, Vancouver, British Columbia, Canada

Howard Tennen

Department of Psychiatry, University of Connecticut Health Center,

Farmington, CT, USA

Michael E. Thase

Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

Mauricio Tohen

McLean Hospital, Harvard Medical School, Boston, MA, USA

Martha C. Tompson

Department of Psychology, Boston University, Boston, MA, USA

Kenneth E. Towbin

Division of Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA Department of Psychiatry and Bahavioral Sciences, George Washington University School of Medicine, Washington, DC, USA

Jane A. Ungemack

Department of Community Medicine and Health Care, University of

Connecticut School of Medicine, Farmington, CT, USA

Robert J. Ursano

Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

Amy M. Ursano

Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA

George Vaillant

Department of Psychiatry, Harvard Medical School, Boston, MA, USA Department of Psychiatry, Brigham and Women’s Hospital, Boston, MA, USA

Susan C. Vaughan

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Columbia University Center for Psychoanalytic Training and Research, Columbia University, New York, NY, USA

Simone N. Vigod

University Health Network, University of Toronto, Toronto, Ontario, Canada

Fred R. Volkmar

Yale Child Study Center, New Haven, CT, USA

Nora D. Volkow

National Institute on Drug Abuse, Bethesda, MD, USA

John T. Walkup

Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD, USA

B. Timothy Walsh

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, USA

Philip S. Wang

Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, MD, USA

Daniel S. Weiss

Department of Psychiatry, University of California, San Francisco, CA, USA

Donald R. Wesson

Hythiam, Inc., Los Angeles, CA, USA

Christina G. Weston

Department of Psychiatry, Wright State University Boonshoft School of Medicine, Dayton, OH, USA

Alexander Westphal

Yale Child Study Center, New Haven, CT, USA

Thomas A. Widiger

Department of Psychology, University of Kentucky, Lexington, KY, USA

Serena Wieder

Interdisciplinary Council for Developmental and Learning Disorders, George Washington University Medical School, Bethesda, MD, USA

Maija L. Wilska

Rinnekoti Foundation, Espoo, Finland

George E. Woody

Substance Abuse Treatment and Research Center, University of Pennsylvania, Philadelphia, PA, USA

Jesse H. Wright

Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, USA

Roy Yaari

Banner Alzheimer’s Institute, Arizona Alzheimer’s Consortium, Phoenix, AZ, USA

Kimberly A. Yonkers

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

Shu-Han Yu

Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Taipei, Taiwan

Sean H. Yutzy

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

Jamil Zaki

Department of Psychology, Columbia University, New York, NY, USA

Charles H. Zeanah

Institute of Infant and Early Childhood Mental Health, Tulane University Health Sciences Center, New Orleans, LA, USA

Department of Psychiatry and Neurology, Tulane University Health Sciences Center, New Orleans, LA, USA

Douglas Ziedonis

Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA

Preface to this Edition

Time and science march on, and thus, a new edition of Psychiatry is now before you. The advances in our field continue at a rapid pace, with an ongoing transformation of our understanding of brain and mental functioning, and the development of ever more sophisticated treatments. We continue to feel tremendous gratitude to our colleagues, whose acceptance of Psychiatry has led to it becoming a leading reference text around the world.

This edition is marked not only by extensive revision of all chapters, and by the addition of many new chapters, but also by a major restructuring of the book. Where before there were seven major sections, there are now nine, reflecting both the expansion of our knowledge base, and what we believe will be a more useful organization of the material.

With all the revising and restructuring though, our philosophical preference continues to emphasize an integrative approach to both understanding psychopathology and providing treatment. And, as always, we hold to the view that the context of our understanding and intervention remains the therapeutic alliance we develop and maintain with our patients.

You will also see that we have expanded our panel of editors, reflecting both the breadth of the field, and the increasingly international scope of our work. Our two new editors are Michael First, MD and Mario Maj, MD. Professor Michael First in New York is an internationally known psychiatrist in the area of diagnostic classification, and one of the leaders in the development of the DSM-IV and DSM-IV-TR. Professor Mario Maj is chair of psychiatry at the University of Naples, Italy, an internationally known scholar in several areas, and incoming president of the World Psychiatric Association.

Psychiatry’s success and international acceptance reflects the outstanding contributions of several hundred of the most eminent and scholarly group of colleagues with whom one could ever hope to work. As always, their diligence and commitment to excellence made the work of the section editors and editors much easier than one might imagine. Great thanks go to all the authors and section editors, who deserve the highest accolades for the quality of this work.

Thanks also go to all those at Wiley-Blackwell involved in the publication of this work. Special thanks go to Joan Marsh, Andrew Spong, Layla Paggetti, Jill Hawthorne, and Kerry Powell for their commitment to the project. None of the editors could have accomplished their work without the devoted assistance of their home-based secretaries and assistants, all of whom have our thanks.

Most importantly, special thanks go to our families, who, once again, tolerated hours of our reviewing manuscripts and correcting proofs, hours which otherwise would have been spent with them.

ALLAN TASMAN, MD

JERALD KAY, MD

JEFFREY A. LIEBERMAN, MD

MICHAEL B. FIRST, MD

MARIO MAJ, MD