Kadic, E., Heindel, T.J.
An Introduction to Bioreactor Hydrodynamics and Gas-Liquid Mass Transfer
2014
Print ISBN: 978-1-118-10401-9; also available in electronic formats
Lutz, S., Bornscheuer, U.T. (eds.)
Protein Engineering Handbook
Volume 3
2013
Print ISBN: 978-3-527-33123-9; also available in electronic formats
Buchholz, K., Kasche, V., Bornscheuer, U.T.
Biocatalysts and Enzyme Technology
2 Edition
2012
Print ISBN: 978-3-527-32989-2; also available in electronic formats
Mandenius, C., Björkman, M.
Biomechatronic Design in Biotechnology
A Methodology for Development of Biotechnological Products
2011
Print ISBN: 978-0-470-57334-1; also available in electronic formats
Mosier, N.S., Ladisch, M.R.
Modern Biotechnology
Connecting Innovations in Microbiology and Biochemistry to Engineering Fundamentals
2009
Print ISBN: 978-0-470-11485-8; also available in electronic formats
Planned Volumes of the “Advanced Biotechnology” Series:
Applied Bioengineering
T. Yoshida (Osaka University, Japan)
Emerging Areas in Bioengineering
H. N. Chang (KAIST, Korea)
Micro- and Nanosystems for Biotechnology
C. Love (MIT, USA)
Industrial Biotechnology
C. Wittmann & J. Liao (Saarland University, Germany & UCLA, USA)
Synthetic Biology
S. Panke & C. Smolke (ETH Zürich, Switzerland & Stanford University, USA)
Systems Biology
J. Nielsen & S. Hohmann (Chalmers University, Sweden & Gothenburg University, Sweden)
Edited by John Villadsen
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© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Boschstr. 12, 69469 Weinheim, Germany
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ISSN: 2365-3035
Print ISBN: 978-3-527-33674-6
ePDF ISBN: 978-3-527-69746-5
ePub ISBN: 978-3-527-69745-8
Mobi ISBN: 978-3-527-69747-2
oBook ISBN: 978-3-527-69744-1
Basti Bergdahl
Danmarks Tekniske Universitet
Novo Nordisk Foundation Center for Biosustainability
Kogle Allé 6
2970 Hørsholm
Denmark
Jochen Förster
Danmarks Tekniske Universitet
Novo Nordisk Foundation Center for Biosustainability
Kogle Allé 6
2970 Hørsholm
Denmark
Thomas Grotkjær
Novozymes A/S
Biomass Conversion Business Development
Novo Allé
2880 Bagsvaerd
Copenhagen
Denmark
Markus Herrgård
Danmarks Tekniske Universitet
Novo Nordisk Foundation Center for Biosustainability
Kogle Allé 6
2970 Hørsholm
Denmark
Jakob Kjøbsted Huusom
Technical University of Denmark
Department of Chemical and Biochemical Engineering
Anker Engelunds Vej 1
Bygning 101A
2800 Kgs Lyngby
Denmark
Daniel Machado
Universidade do Minho
Centro de Engenharia Biológica
4710-057 Braga
Portugal
Sunil Nath
Indian Institute of Technology, Delhi
Department of Biochemical Engineering and Biotechnology
Hauz Khas
New Delhi 110016
India
Sebastian Niedenführ
Forschungszentrum Jülich GmbH
Institute of Bio- and Geosciences
IBG-1: Biotechnology
52425 Jülich
Germany
Katharina Nöh
Forschungszentrum Jülich GmbH
Institute of Bio- and Geosciences
IBG-1: Biotechnology
52425 Jülich
Germany
Henk Noorman
DSM Biotechnology Center
A. Fleminglaan 1
2613 CA Delft
The Netherlands
Matthias Reuss
University of Stuttgart
Stuttgart Research Center Systems Biology
Nobelstr. 15
70569 Stuttgart
Germany
Nikolaus Sonnenschein
Danmarks Tekniske Universitet
Novo Nordisk Foundation Center for Biosustainability
Kogle Allé 6
2970 Hørsholm
Denmark
Bernhard Sonnleitner
Zurich University of Applied Sciences (ZHAW)
Institute for Chemistry and Biological Chemistry (ICBC)
Biochemical Engineering
Einsiedlerstrasse 29
8820 Waedenswil
Switzerland
John Villadsen
Technical University of Denmark (DTU)
Department of Chemical and Biochemical Engineering
Building 229
2800 Kgs Lyngby
Denmark
Wolfgang Wiechert
Forschungszentrum Jülich GmbH
Institute of Bio- and Geosciences
IBG-1: Biotechnology
52425 Jülich
Germany
Sang Yup Lee is Distinguished Professor at the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science and Technology. At present, Prof. Lee is the Director of the Center for Systems and Synthetic Biotechnology, Director of the BioProcess Engineering Research Center, and Director of the Bioinformatics Research Center. He has published more than 500 journal papers, 64 books, and book chapters, and has more than 580 patents (either registered or applied) to his credit. He has received numerous awards, including the National Order of Merit, the Merck Metabolic Engineering Award, the ACS Marvin Johnson Award, Charles Thom Award, Amgen Biochemical Engineering Award, Elmer Gaden Award, POSCO TJ Park Prize, and HoAm Prize. He is Fellow of American Association for the Advancement of Science, the American Academy of Microbiology, American Institute of Chemical Engineers, Society for Industrial Microbiology and Biotechnology, American Institute of Medical and Biological Engineering, the World Academy of Science, the Korean Academy of Science and Technology, and the National Academy of Engineering of Korea. He is also Foreign Member of National Academy of Engineering, USA. In addition, he is honorary professor of the University of Queensland (Australia), honorary professor of the Chinese Academy of Sciences, honorary professor of Wuhan University (China), honorary professor of Hubei University of Technology (China), honorary professor of Beijing University of Chemical Technology (China), and advisory professor of the Shanghai Jiaotong University (China). Apart from his academic associations, Prof. Lee is the editor-in-chief of the Biotechnology Journal and is also contributing to numerous other journals as associate editor and board member. Prof. Lee is serving as a member of Presidential Advisory Committee on Science and Technology (South Korea).
Jens Nielsen is Professor and Director to Chalmers University of Technology (Sweden) since 2008. He obtained an MSc degree in chemical engineering and a PhD degree (1989) in biochemical engineering from the Technical University of Denmark (DTU) and after that established his independent research group and was appointed full professor there in 1998. He was Fulbright visiting professor at MIT in 1995–1996. At DTU, he founded and directed the Center for Microbial Biotechnology. Prof. Nielsen has published more than 350 research papers and coauthored more than 40 books, and he is inventor of more than 50 patents. He has founded several companies that have raised more than 20 million in venture capital. He has received numerous Danish and international awards and is member of the Academy of Technical Sciences (Denmark), the National Academy of Engineering (USA), the Royal Danish Academy of Science and Letters, the American Institute for Medical and Biological Engineering and the Royal Swedish Academy of Engineering Sciences.
Gregory Stephanopoulos is the W.H. Dow Professor of Chemical Engineering at the Massachusetts Institute of Technology (MIT, USA) and Director of the MIT Metabolic Engineering Laboratory. He is also Instructor of Bioengineering at Harvard Medical School (since 1997). He received his BS degree from the National Technical University of Athens and his PhD from the University of Minnesota (USA). He has coauthored about 400 research papers and 50 patents, along with the first textbook on metabolic engineering. He has been recognized by numerous awards from the American Institute of Chemical Engineers (AIChE) (Wilhelm, Walker and Founders awards), American Chemical Society (ACS), Society of Industrial Microbiology (SIM), BIO (Washington Carver Award), the John Fritz Medal of the American Association of Engineering Societies, and others. In 2003, he was elected member of the National Academy of Engineering (USA) and in 2014 President of AIChE.
John Villadsen
Bioengineering is a relatively new addition to a long list of terms starting with “bio.” It is broadly defined as “the application of engineering principles to biological systems.” Bioengineering can include elements of chemical, electrical and mechanical engineering, computer science, materials, chemistry and biology. The systems that are analyzed range from cell cultures and enzymes applied in the bio-industry and in bioremediation to prosthetics, construction of models for organs such as liver, drug-delivery systems and numerous other subjects in biomedical engineering, all requiring an understanding of transport phenomena (mass, heat, and momentum transfer) and kinetics, combined in often large mathematical models. Besides a working knowledge of these core chemical engineering disciplines, a successful study of a problem in bioengineering requires an insight into the core disciplines of biology and biochemistry, specifically in human physiology when the goal is, for example, to construct a new cancer drug delivery system.
In this volume, coauthored by nine scientists, mostly working in academic institutions or in the bio-industry, the focus is on application of bioengineering in the emerging “white biotechnology” industry. The design of bioremediation systems closely follows the principles of analysis and design of industrial bioprocesses. This text will also prove valuable for environmental engineers. The biomedical applications of the text are, however, also quite obvious. Thus, the important but complex application of mesenchymal stem cells to treat osteoporosis is based on an optimal growth strategy of the cell culture on a scaffold at the right liquid flow with the right oxygen and nutrient availability. Here, kinetics and transport phenomena are coupled to basic biology and biochemistry, and design of the system is based on a complex model for the interaction between scaffold, cells, and nutrients.
In Chapters 5, 6, and 8, the reader will find self-contained accounts of the tools that together make it possible to understand the behavior of cell cultures and enzymatically catalyzed reactions: The interaction of metabolic network reactions in steady state and during transients, analyzed by mathematical models and solved by state-of-the-art computer software.
In Chapter 16, a structural framework for successful scale-up of bioreactions from laboratory scale to large industrial scale is presented. In Chapter 17, the sequence of management decisions that may lead to new business ventures in the bio-industry is discussed.
The analyses of cultures on the level of the cell are authored by three leading European scientists. Each author gives - as far as possible - a complete account of his subject, illustrated with examples and with sufficient detail to give readers, both in industry and in graduate classes at universities, a fair chance to understand and utilize the very powerful analytical tools presented in the three chapters.
The two Chapters 16 and 17 on large-scale bioreactors and on the business opportunities in the bio-industry are written by leading experts from two major bio-industrial companies, DSM in the Netherlands and Novozymes in Denmark. These chapters could serve as guidelines for prospective business ventures in the industry.
Although the focus of this book is on the bioreactor, Chapters 12 and 13 cover further processing of the effluent from the bioreactor. The author, a distinguished Indian bioscientist, gives a short introduction to the subject of downstream processing. Also, a survey of measuring, monitoring, and control of bioreactions is included. In Chapter 14, a leading expert on chemical analysis to capture key fermentation variables and on using the experimental data in analysis of fermentation broths gives an easy-to-read but largely complete survey of the subject. In Chapter 15, a young expert in control of chemical processes, discusses control problems in bioreactors, specifically addressing the challenges of bio-system control.
Finally, the content of the book is tied together by seven chapters (2, 3, 4, 7, 9, 10, and 11) written by the editor of this work. These chapters introduce a common nomenclature for the whole book, with introductory material on stoichiometry, kinetics, thermodynamics, and design of ideal and real bioreactors. It is hoped that the introductory chapters, illustrated with many simple examples, will make it easier to read the advanced chapters, especially since there are frequent cross references between introductory and advanced chapters.