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Advances in Pharmaceutical Technology

A Wiley Book Series

Series Editors:

Dennis Douroumis, University of Greenwich, UK

Alfred Fahr, Friedrich–Schiller University of Jena, Germany

Judoubleacutergen Siepmann, University of Lille, France

Martin Snowden, University of Greenwich, UK

Vladimir Torchilin, Northeastern University, USA

 


 

Titles in the Series

 

Hot-Melt Extrusion: Pharmaceutical Applications

Edited by Dionysios Douroumis

 

Drug Delivery Strategies for Poorly Water-Soluble Drugs

Edited by Dionysios Douroumis and Alfred Fahr

 

Computational Pharmaceutics Application of Molecular Modeling in Drug Delivery

Edited by Defang Ouyang and Sean C. Smith

 

Forthcoming titles:

 

Novel Delivery Systems for Transdermal and Intradermal Drug Delivery

Edited by Ryan F. Donnelly and Thakur Raghu Raj Singh

Pulmonary Drug Delivery

Advances and Challenges

Edited by

ALI NOKHODCHI AND GARY P. MARTIN

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List of Contributors

  1. Iman M. Alfagih, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, UK; College of Pharmacy, Woman Students Medical Studies and Science Sections, King Saud University, Saudi Arabia
  2. Hatim S. AlKhatib, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Jordan, Jordan
  3. Karim Amighi, Laboratory of Pharmaceutics and Biopharmaceutics, Faculty of Pharmacy, Université Libre de Bruxelles (ULB), Belgium
  4. Anna Giulia Balducci, Interdepartmental Center, Biopharmanet-TEC, University of Parma, Italy; PlumeStars s.r.l., Parma, Italy
  5. Jaleh Barar, Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran
  6. David Barling, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, University of Monash, Australia
  7. Ruggero Bettini, Department of Pharmacy, University of Parma, Italy
  8. Francesca Buttini, Department of Pharmacy, University of Parma, Italy; Institute of Pharmaceutical Science, King's College London, UK
  9. Simone R. Carvalho, Division of Pharmaceutics, The University of Texas at Austin, College of Pharmacy, USA
  10. Lai Wah Chan, GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore
  11. Paolo Colombo, Department of Pharmacy, University of Parma, Italy
  12. Nabil Darwazeh, Tabuk Pharmaceutical Research Co., Amman, Jordan
  13. Stephen Dubsky, Department of Mechanical and Aerospace Engineering, Faculty of Engineering, Monash University, Australia
  14. Marie-Pierre Flament, Faculty of Engineering and Management of Health, University of Lille 2, France
  15. Ben Forbes, Institute of Pharmaceutical Science, King's College London, UK
  16. Andreas Fouras, Department of Mechanical and Aerospace Engineering, Faculty of Engineering, Monash University, Australia
  17. Lucila Garcia-Contreras, Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, USA
  18. Mark Gumbleton, Welsh School of Pharmacy, Cardiff University, Wales
  19. Hamed Hamishehkar, Drug Applied Research Center, Tabriz University of Medical Sciences, Iran
  20. Karen Hapgood, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, University of Monash, Australia
  21. Paul Wan Sia Heng, GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore
  22. Gillian A. Hutcheon, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, UK
  23. Mariam Ibrahim, Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, USA
  24. Rim Jawad, Institute of Pharmaceutical Science, King's College London, UK
  25. Waseem Kaialy, School of Pharmacy, Faculty of Science and Engineering, University of Wolverhampton, UK
  26. Nitesh K. Kunda, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, UK
  27. Orest Lastow, Iconovo AB, Medicon Village, Lund, Sweden
  28. Celine Valeria Liew, GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore
  29. Gary P. Martin, Institute of Pharmaceutical Science, King's College London, UK
  30. David Morton, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, University of Monash, Australia
  31. Sami Nazzal, College of Health and Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, USA
  32. Ali Nokhodchi, School of Life Sciences, University of Sussex, UK; Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran
  33. Yadollah Omidi, Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran
  34. Jay I. Peters, Department of Medicine, Division of Pulmonary Diseases/Critical Care Medicine, The University of Texas Health Science Center at San Antonio, USA
  35. Yahya Rahimpour, Biotechnology Research Center and Student Research Committee, Tabriz University of Medical Sciences, Iran
  36. Paul G. Royall, Institute of Pharmaceutical Science, King's College London, UK
  37. Nathalie Hauet Richer, Institute of Pharmaceutical Science, King's College London, UK
  38. Imran Y. Saleem, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, UK
  39. Al Sayyed Sallam, Al Taqaddom Pharmaceutical Industries Co., Jordan
  40. Bernice Mei Jin Tan, GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore
  41. Rahul K. Verma, Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, USA
  42. Alan B. Watts, College of Pharmacy, Drug Dynamics Institute, The University of Texas at Austin, USA
  43. Nathalie Wauthoz, Laboratory of Pharmaceutics and Biopharmaceutics, Faculty of Pharmacy, Université Libre de Bruxelles (ULB), Belgium
  44. Robert O. Williams III, Division of Pharmaceutics, The University of Texas at Austin, College of Pharmacy, USA

Advances in Pharmaceutical Technology

Series Preface

The series Advances in Pharmaceutical Technology covers the principles, methods, and technologies that the pharmaceutical industry use to turn a candidate molecule or new chemical entity into a final drug form and hence a new medicine. The series will explore means of optimizing the therapeutic performance of a drug molecule by designing and manufacturing the best and most innovative of new formulations. The processes associated with the testing of new drugs, the key steps involved in the clinical trials process, and the most recent approaches utilized in the manufacture of new medicinal products will all be reported. The focus of the series will very much be on new and emerging technologies and the latest methods used in the drug development process.

The topics covered by the series include:

  1. Formulation: The manufacture of tablets in all forms (caplets, dispersible, and fast-melting) will be described, as will capsules, suppositories, solutions, suspensions and emulsions, aerosols and sprays, injections, powders, ointments and creams, sustained release, and the latest transdermal products. The developments in engineering associated with fluid, powder and solids handling, solubility enhancement, colloidal systems including the stability of emulsions and suspensions will also be reported within the series. The influence of formulation design on the bioavailability of a drug will be discussed and the importance of formulation with respect to the development of an optimal final new medicinal product will be clearly illustrated.
  2. Drug Delivery: The use of various excipients and their role in drug delivery will be reviewed. Amongst the topics to be reported and discussed will be a critical appraisal of the current range of modified-release dosage forms currently in use and also those under development. The design and mechanism(s) of controlled release systems including; macromolecular drug delivery, microparticulate controlled drug delivery, the delivery of biopharmaceuticals, delivery vehicles created for gastro-intestinal tract targeted delivery, transdermal delivery, and systems designed specifically for drug delivery to the lung will all be reviewed and critically appraised. Further site-specific systems used for the delivery of drugs across the blood brain barrier including dendrimers, hydrogels, and new innovative biomaterials will be reported.
  3. Manufacturing: The key elements of the manufacturing steps involved in the production of new medicines will be explored in this series. The importance of crystallization; batch and continuous processing, seeding; mixing including a description of the key engineering principles relevant to the manufacture of new medicines will all be reviewed and reported. The fundamental processes of quality control including good laboratory practice (GLP), good manufacturing practice (GMP), quality by design (QbD), the Deming cycle; regulatory requirements and the design of appropriate robust statistical sampling procedures for the control of raw materials will all be an integral part of this book series.

An evaluation of the current analytical methods used to determine drug stability, the quantitative identification of impurities, contaminants, and adulterants in pharmaceutical materials will be described as will the production of therapeutic bio-macromolecules, bacteria, viruses, yeasts, molds, prions, and toxins through chemical synthesis and emerging synthetic/molecular biology techniques. The importance of packaging including the compatibility of materials in contact with drug products and their barrier properties will also be explored.

Advances in Pharmaceutical Technology is intended as a comprehensive one-stop shop for those interested in the development and manufacture of new medicines. The series will appeal to those working in the pharmaceutical and related industries, both large and small, and will also be valuable to those who are studying and learning about the drug development process and the translation of those drugs into new life saving and life-enriching medicines.

Dennis Douroumis
Alfred Fahr
Juergen Siepmann
Martin Snowden
Vladimir Torchilin