Table of Contents
Cover
Title Page
Copyright
Chapter 1: Defining the Field of Sequence-Controlled Polymers
1.1 Introduction
1.2 Glossary
1.3 Sequence Regulation in Biopolymers
1.4 Bio-Inspired Sequence-Regulated Approaches
1.5 Sequence Regulation in Synthetic Macromolecules
1.6 Characterization of SCPs
1.7 Impact in Materials Science
1.8 Some Words About the Future
References
Chapter 2: Kinetics and Thermodynamics of Sequence Regulation
2.1 Introduction
2.2 Generalities
2.3 Thermodynamics
2.4 Kinetics Yielding Bernoulli Chains
2.5 Kinetics Yielding Markov Chains
2.6 Kinetics Yielding Non-Markovian Chains
2.7 Effect of Sequence Disorder on Ceiling and Floor Temperatures
2.8 Mechanical Power of Sequence Disorder
2.9 Template-Directed Copolymerization
2.10 Conclusion
Acknowledgments
References
Chapter 3: Nucleic Acid-Templated Synthesis of Sequence-Defined Synthetic Polymers
3.1 Introduction
3.2 Enzymatic Templated Syntheses of Non-Natural Nucleic Acids
3.3 Ribosomal Synthesis of Non-Natural Peptides
3.4 Nonenzymatic Polymerization of Nucleic Acids
3.5 Nonenzymatic Polymerization of Non-Nucleic Acid Polymers
3.6 Conclusion and Outlook
Acknowledgments
References
Chapter 4: Design of Sequence-Specific Polymers by Genetic Engineering
4.1 Introduction
4.2 Design of Repetitive Protein Polymers
4.3 Methods for the Genetic Synthesis of Repetitive Protein Polymers
4.4 Expression of Repetitive Protein Polymers
4.5 Expanding the Chemical Repertoire of Protein Polymers
4.6 Summary and Outlook
References
Chapter 5: Peptide Synthesis and Beyond the Use of Sequence-Defined Segments for Materials Science
5.1 Introduction
5.2 The History of Solid-Phase-Supported Peptide Synthesis
5.3 Supports for the Chemical Synthesis of Peptides
5.4 Synthesis of Peptide–Polymer Conjugates
5.5 Identification of Functional Sequences
5.6 Sequence–Property Relationships
5.7 Translation of Sequence to Synthetic Precision Polymer Platforms
5.8 Conclusion
References
Chapter 6: Iterative Synthetic Methods for the Assembly of Sequence-Controlled Non-Natural Polymers
6.1 Introduction
6.2 The Solid-Phase Approach
6.3 The Liquid-Phase Approach
6.4 The Template Approach
6.5 A Support-Free Approach
6.6 Outlook
References
Chapter 7: Sequence-Controlled Peptoid Polymers
7.1 Introduction
7.2 Peptoids – Bridging the Gap
7.3 Polypeptoid Synthesis
7.4 Discovering Peptoid Properties Derived from Sequence Control
7.5 Conclusion
Acknowledgments
References
Chapter 8: Sequence and Architectural Control in Glycopolymer Synthesis
8.1 Introduction: Glycopolymer–Lectin Binding
8.2 Sequence-Controlled Glycopolymers
8.3 Self-Assembly of Glycopolymers
8.4 Single-Chain Folding of Glycopolymers: The Future?
8.5 General Conclusion and Future Outlook
Acknowledgments
References
Chapter 9: Sequence Regulation in Chain-Growth Polymerizations
9.1 Introduction
9.2 Alternating Copolymerization
9.3 Iterative Single-Unit Addition with Living Polymerization
9.4 Template-Assisted Polymerization
9.5 Cyclopolymerization
9.6 Ring-Opening Polymerization of Sequence-Programmed Monomer
9.7 Conclusion
References
Chapter 10: Sequence-Controlled Polymers by Chain Polymerization
10.1 Introduction
10.2 Sequence-Controlled Polymers by Various Polymerization Mechanisms
10.3 Concluding Remarks
References
Chapter 11: Sequence-Controlled Polymers via Cationic Polymerization
11.1 Introduction
11.2 Recent Developments in Living Cationic Polymerization
11.3 Sequence-Regulated Functional Polymers
11.4 Sequence Control Based on the Cationic Copolymerization of Vinyl and Cyclic Monomers
References
Chapter 12: Periodic Copolymers by Step-Growth Polymerization
12.1 Introduction
12.2 Carbon-Chain Periodic Polymers
12.3 Hetero-Chain Periodic Polymers
12.4 Conclusions and Outlook
References
Chapter 13: Click and Click-Inspired Chemistry for the Design of Sequence-Controlled Polymers
13.1 Introduction to “Click” and Click-Inspired Reactions Within the Area of Sequence-Controlled Polymers
13.2 Click and Click-Inspired Reactions for Sequence Building
13.3 Conclusions and Outlook
References
Chapter 14: One-Pot Sequence-Controlled (SC) Multiblock Copolymers via Copper-Mediated Polymerization
14.1 Introduction
14.2 Criteria for the Successful Synthesis of SC Multiblock Copolymers
14.3 Historical Background toward the Development of One-Pot SC Multiblocks
14.4 Access to SC Acrylic Multiblock Copolymers
14.5 Access to SC Acrylamide Multiblock Copolymers (The CuBr/Me
6
Tren Disproportionation Technique)
14.6 Perspective and Outlook
References
Chapter 15: Properties and Applications of Sequence-Controlled Polymers
15.1 Introduction
15.2 Molecular Properties
15.3 Solution-Phase Properties
15.4 Sequence Dependence of Bulk-Phase Properties
15.5 Conclusions and Outlook
References
Chapter 16: Tandem Mass Spectrometry Sequencing of Sequence-Controlled and Sequence-Defined Synthetic Polymers
16.1 Introduction
16.2 MS/MS Principle
16.3 MS/MS of Sequence-Controlled Copolymers
16.4 MS/MS of Sequence-Defined Polymers
16.5 Conclusions and Perspectives
References
Index
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