This edition first published 2018
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ISBN: 9781119065012
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Sinan Akgol
Department of Biochemistry, Faculty of Science
Ege University
Izmir
Turkey
Deniz Aktas‐Uygun
Department of Chemistry, Faculty of Science and Arts
Adnan Menderes University
Aydin
Turkey
Zeynep Altintas
Technical University of Berlin
Berlin
Germany
Adina Arvinte
“Petru Poni” Institute of Macromolecular Chemistry
Centre of Advanced Research in Bionanoconjugates and Biopolymers
Iasi
Romania
Mohammad Asghari
Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM)
Bilkent University
Ankara
Turkey
Jon Ashley
Department of Micro‐ and Nanotechnology
Technical University of Denmark
Lyngby
Denmark
Eren Aydın
Department of Electrical and Electronics Engineering
Middle East Technical University
Ankara
Turkey
Frank Davis
Department of Engineering and Applied Design
University of Chichester
Chichester
UK
Ece Eksin
Department of Analytical Chemistry, Faculty of Pharmacy
Ege University
Izmir
Turkey
Caglar Elbuken
Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM)
Bilkent University
Ankara
Turkey
Arzum Erdem
Department of Analytical Chemistry, Faculty of Pharmacy
Ege University
Izmir
Turkey
Wellington M. Fakanya
Atlas Genetics Ltd
Wiltshire
UK
Furkan Gökçe
Department of Electrical and Electronics Engineering
Middle East Technical University
Ankara
Turkey
Mustafa Tahsin Guler
Department of Physics
Kirikkale University
Kirikkale
Turkey
Ziya Isiksacan
Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM)
Bilkent University
Ankara
Turkey
Ali Kalantarifard
Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM)
Bilkent University
Ankara
Turkey
Mustafa Kangül
Department of Electrical and Electronics Engineering
Middle East Technical University
Ankara
Turkey
Ece Kesici
Department of Analytical Chemistry, Faculty of Pharmacy
Ege University
Izmir
Turkey
Haluk Külah
Department of Electrical and Electronics Engineering
Middle East Technical University
Ankara
Turkey
Giovanna Marrazza
Department of Chemistry “Ugo Schiff”
University of Florence
Florence
Italy
Noor Azlina Masdor
Cranfield University
Cranfield
UK
and
Malaysian Agricultural Research and Development Institute (MARDI)
Kuala Lumpur
Malaysia
Ebru Özgür
Department of Electrical and Electronics Engineering
Middle East Technical University
Ankara
Turkey
Andrea Ravalli
Department of Chemistry “Ugo Schiff”
University of Florence
Florence
Italy
Frieder W. Scheller
Institute of Biochemistry and Biology
University of Potsdam
Potsdam
Germany
Adama Marie Sesay
Unit of Measurement Technology, Kajaani University Consortium
University of Oulu
Oulu
Finland
Flavio M. Shimizu
São Carlos Institute of Physics (IFSC)
University of São Paulo (USP)
São Carlos
Brazil
Yi Sun
Department of Micro‐ and Nanotechnology
Technical University of Denmark
Lyngby
Denmark
Pirkko Tervo
Unit of Measurement Technology, Kajaani University Consortium
University of Oulu
Oulu
Finland
Elisa Tikkanen
Unit of Measurement Technology, Kajaani University Consortium
University of Oulu
Oulu
Finland
Murat Uygun
Department of Chemistry, Faculty of Science and Arts
Adnan Menderes University
Aydin
Turkey
Özge Zorlu
Department of Electrical and Electronics Engineering
Middle East Technical University
Ankara
Turkey
Multifactorial diseases such as cancer, cardiovascular disorders, and infectious diseases are the leading cause of death worldwide. This is mostly due to the lack of early diagnosis, which plays a key role in successful treatment and in elimination of huge costs required for the treatment. Today, common use of biosensor technology in the field of medical diagnostics and drug discovery has resulted in cost‐effective, rapid, reliable, and easy‐to‐use sensing platforms. Biomedical sensors are analytical devices that utilize recognition elements such as antibodies, aptamers, peptides, and molecularly imprinted polymers for detection. They possess two main elements: (i) a biological recognition element (receptor) that supplies specific binding through a biochemical interaction of a target to a receptor and (ii) a signal transducer that converts this biochemical reaction into an easily measurable electrical signal. Other components of biosensors are the input/output systems to operate the sensing device and fluidics systems to handle reagents and samples necessary for the testing. In this book, we aim to describe a range of biosensor technologies for the detection of cancer, cardiac problems, and neurodegenerative and infectious diseases with the hope of helping the integration of biomedical sensors into common clinical usage.
Advancements taking place in nanotechnology, microelectronics, computational science, and biomedical engineering have led to new technologies and application‐specific devices by bringing various disciplines together. However, there is still a gap between research and clinical applications. Taking this fact into account, the objective of this book is to provide a wide range of information from basic to the advanced applications in the biosensor area and impact of nanotechnology on the development of biosensors for healthcare. A significant up‐to‐date review of various sensor platforms, their use in cancer, cardiovascular system problems, neurodegenerative disorders, infectious diseases, and drug discovery with the implementations of smart nanomaterials is also given. This project is a comprehensive approach to the medical biosensors area presenting a thorough knowledge of the subject and an effective integration of these sensors on healthcare in order to appropriately convey the state‐of‐the‐art fundamentals and applications of the most innovative technologies.
This book is comprised of 15 chapters written by 31 researchers who are actively working in Germany, the United Kingdom, Italy, Turkey, Denmark, Finland, Romania, Malaysia, and Brazil. The book covers four main sections: Section 1 describes general information on biosensors, recognition receptors, biomarkers, and disease diagnostics. Section 2 provides biosensor‐based healthcare applications through various sensing systems, and it covers all main types of biosensors including surface plasmon resonance‐, piezoelectric‐, electrochemical‐, microelectromechanical‐, and lab‐on‐a‐chip‐based sensors in disease detection and diagnostics. Applications of nanomaterials in biosensors and diagnostics follow this part as the third main section, Section 3, and it talks about the application of quantum dots, carbon nanotubes, metal nanoparticles, molecularly imprinted nanostructures, magnetic nanomaterials, and graphene with the latest trends in the field. The last section, Section 4, is dedicated to organ‐specific healthcare applications for disease cases using biosensors. In this part, optical biosensors and applications to drug discovery for cancer cases, and also DNA‐based biosensors for anticancer drug detection, are covered.
The anticipated audience is researchers, scientists, regulators, consultants, and engineers. Furthermore, graduate students will find this book very useful since it provides a wide range of knowledge on biosensors for healthcare diagnostics. The contributors of the book were also asked to use a pedagogical tone to comply with the needs of novice researchers such as doctoral students and postdoctoral scholars as well as of senior researchers seeking new pathways. All related and significant subtopics are given in one book to provide a not only comprehensive but also easily understandable handbook in the area. Educational purposes were also considered while generating this book; hence it has a great potential to be used as a textbook in universities and research institutes. The complexity and flow of the book is suitable for all related and interested students in the area.
March 2017, Berlin
Zeynep Altintas
Department of Chemical Engineering
and
Department of Biomolecular Modelling
Technical University of Berlin, Germany
We are very thankful to all the authors for their participation and invaluable contributions in the making of this book. I also extend my thanks to Tom Scrace and Sumathi Elangovan of John Wiley who assisted me in all stages of preparing this book for the publication. Last, but not least, I dedicate this book to my parents, Ilyas and Eva, with sincere regards and my niece, Beren, who inspired me while working on the book.