Details

Pharmacogenomics in Clinical Therapeutics


Pharmacogenomics in Clinical Therapeutics


2. Aufl.

von: Loralie J. Langman, Amitava Dasgupta

102,99 €

Verlag: Wiley-Blackwell
Format: PDF
Veröffentl.: 31.01.2012
ISBN/EAN: 9781119959571
Sprache: englisch
Anzahl Seiten: 400

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Beschreibungen

Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. <p><i>Pharmacogenomics in Clinical Therapeutics</i> provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions.</p> <p>From a team of expert contributors, <i>Pharmacogenomics in Clinical Therapeutics</i> is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.</p>
List of Contributors, vii <p>Preface, ix</p> <p>1 Pharmacogenomics Principles: Introduction to Personalized Medicine, 1<br /> <i>Parvaz Madadi, PhD and Gideon Koren, MD</i></p> <p>2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? 15<br /> <i>Christine L.H. Snozek, PhD, Loralie J. Langman, PhD, and Amitava Dasgupta, Ph.D</i></p> <p>3 Pharmacogenomics Aspect of Warfarin Therapy, 26<br /> <i>Matthew D. Krasowski, MD, PhD</i></p> <p>4 Pharmacogenetics and Cancer Chemotherapy, 39<br /> <i>Christine L.H. Snozek</i></p> <p>5 Pharmacogenomic Considerations in Anesthesia and Pain Management, 53<br /> <i>Christine M. Formea, PharmD and Wayne T. Nicholson, MD, PharmD</i></p> <p>6 Pharmacogenomics of Immunosuppressants, 70<br /> <i>Nicolas Picard, PharmD, PhD and Pierre Marquet, MD, PhD</i></p> <p>7 Pharmacogenomics of Cardiovascular Drugs, 98<br /> <i>Linnea M. Baudhuin, PhD</i></p> <p>8 Pharmacogenomic Aspects of Antiretroviral Therapy, 127<br /> <i>Natella Y. Rakhmanina, MD, PhD and John N. van den Anker, MD, PhD</i></p> <p>9 Pharmacogenetics of Psychoactive Drugs, 144<br /> <i>Jorge L. Sepulveda, MD, PhD</i></p> <p>10 Pharmacogenomic Aspects of Adverse Drug–Drug Interactions, 176<br /> <i>Loralie J. Langman, PhD and Christine L.H. Snozek, PhD</i></p> <p>11 Microarray Technology and Other Methods in Pharmacogenomics Testing, 185<br /> <i>Jorge L. Sepulveda, MD, PhD</i></p> <p>12 Pharmacogenetic Testing in the Clinical Laboratory Environment, 201<br /> <i>Mark P. Borgman, PhD and Mark W. Linder, PhD</i></p> <p>Index, 225</p>
<p>“This book is unique in its focus on the application of pharmacogenomics in clinical therapeutics.”  (<i>Doody’s</i>,<br /> 19 January 2013)</p> <br /> <br /> <p> </p>
<p><strong>Amitava Dasgupta</strong>, Ph.D, DABCC, FACB, Professor of Pathology and Laboratory Medicine, University of Texas Health Sciences Center at Houston, Houston, TX. <p><strong>Loralie J. Langman</strong>, Ph.D, DABCC, FACB, Associate Professor of Laboratory Medicine, Mayo Clinic, Rochester, MN.
Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. <p><i>Pharmacogenomics in Clinical Therapeutics</i> provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions.</p> <p>From a team of expert contributors, <i>Pharmacogenomics in Clinical Therapeutics</i> is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.</p>

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