Pharmaceutical NanotechnologyInnovation and Production, 2 Volumes
Applications of Nanotechnology 1. Aufl.
With its focus on concrete methods and recent advances in applying nanotechnology to develop new drug therapies and medical diagnostics, this book provides an overall picture of the field, from the fundamentals of nanopharmacy with the characterisation and manufacturing methods to the role of nanoparticles and substances. Actual examples of utilization include drug development issues, translation to the clinic, market prospects, and industrial commercialization aspects. The applications described are taken from cancer treatment as well as other major therapeutic areas, such as infectious diseases and dermatology. An in-depth discussion on safety, regulatory, and societal aspects rounds off the book. Written by a top team of editors and authors composed of the leading experts in Europe and the USA who have pioneered the field of nanopharmacy!
Foreword from Rudolf Strohmeier Foreword from Peter Serno Introduction PART I. Entry to the Nanopharmacy Revolution History - Potential, Challenges and Future Development in Nanopharmaceutical Research and Industry Nanoscale Drugs: A Key to Revolutionary Progress in Pharmacy and Healthcare The Emergence of Nanopharmacy: From Biology to Nanotechnology and Drug Molecules to Nanodrugs Understanding and Characterizing Functional Properties of Nanoparticles Omics Based Nanopharmacy: Powerful Tools towards Precision Medicine PART II. Fundamentals of Nanotechnology in Pharmacy Nanostructure in Drug Delivery Nanoparticle Characterization Methods: Physical, Chemical and Biological Techniques Nanoparticle Charactterization Methods: Applications of Synchrotron and Neutral Radiation Preparation and Manufacturing: Overview of Techniques and Processes of Established Processes Preparation and Manufacturing of "Polymeric Materials" Preparation and Manufacturing of "Inorganic Materials" Good Manufacturing Practice (GMP) and Scale-Up Occupational Safety and Health PART III. Development of Nanopharmaceuticals Micro and Nano Tools in Drug Discovery Computational Predictive Models for Nanomedicine Drug Targeting in Nanomedicine and Nanopharmacy: A Systems Approach Nanotoxicology An Overview of Nanoparticle Biocompatibility for their Use in Nanomedicine Translation to the Clinic: Preclinical and Clinical Pharmacology Studies of Nanoparticles Translation to the Clinic: Regulatory Issues Ethical and Societal Aspects PART IV. Pharmaceutical Applications of Nanomaterials Nanoparticles for Imaging and Imaging Nanoparticles: State of the Art and Current Prospects Nanoparticle-Based Physical Methods for Medical Treatments Nanodrugs in Medicine and Healthcare: Oral Delivery Steroid-Loaded Sterically Stabilized Nano-Liposomes for the Treatment of Inflammation Nanodrugs in Medicine and Healthcare: Pulmonary, Nasal and Opthalmic Routes and Vaccination Neurodegenerative Diseases - Alzheimer's Disease PART V. The Nanopharmaceutical Market Patenting and Intellectual Property Issues Commercialization and Nanocarrier-Based Drug Products on the Market Future Outlook of Nanopharmacy: Challenges and Opportunities
Jean Cornier is presently consultant to several companies in the areas of life science, new technologies and business development. He obtained his PhD from the University of Caen, France, and a MSc degree in pharmaceutical medicine from the University of Duisburg-Essen, Germany. Since 1986 he has worked in the space industry as expert in Materials and Life Science research and projects, was participant in space commercialisation initiatives supported by the European and German space agencies as well as in several EU-funded projects in biotechnology and civil security research. Professor Arno Kwade is Head of the Center of Pharmaceutical Engineering and of the Institute of Particle Technology at the Technical University Braunschweig, Germany. After his PhD he worked nine years in industry as partner of a consulting firm for processing and handling of materials and as general manager of a medium-sized company active in materials processing. Professor Kwade is speaker of the European working party on comminution and classification and developed a course on nanomilling, taken by more than 1000 participants from different industries, among them many pharmaceutical companies. Professor Andrew Owen holds a personal Chair in Molecular and Clinical Pharmacology at the University of Liverpool, UK. He is also affiliated to the MRC Centre for Drug Safety Science and the Wolfson Centre for Personalised Medicine. He is Chair of the British Society for Nanomedicine, is co-inventor of several patents related to nanomedicines and has contributed to over 150 publications and book chapters. He is co-founder of University commercial start-ups, a Fellow of the Royal Society of Biology, a Fellow of the British Pharmacological Society and member of the steering committee for the Academy of Pharmaceutical Sciences Nanomedicine Focus Group. Marcel Van de Voorde has 40 years` experience in European Research Organisations including CERN-Geneva, European Commission, with 10 years at the Max Planck Institute in Stuttgart, Germany. For many years, he was involved in research and research strategies, policy and management, especially in European research institutions. He holds a Professorship at the University of Technology in Delft, the Netherlands, as well as multiple visiting professorships in Europe and worldwide. He holds a doctor honoris causa and various honorary Professorships. He is senator of the European Academy for Sciences and Arts, in Salzburg and Fellow of the World Academy for Sciences. He is a Fellow of various scientific societies and has been decorated by the Belgian King. He has authored of multiple scientific and technical publications and co-edited multiple books in the field of nanoscience and nanotechnology.
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