Details

Pathogenomics


Pathogenomics

Genome Analysis of Pathogenic Microbes
1. Aufl.

von: Jörg Hacker, Ulrich Dobrindt, Werner Göbel

169,99 €

Verlag: Wiley-Blackwell
Format: PDF
Veröffentl.: 13.12.2006
ISBN/EAN: 9783527607518
Sprache: englisch
Anzahl Seiten: 616

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Beschreibungen

The first book on this young, highly dynamic, and expanding field.<br> This comprehensive, interdisciplinary text focuses on those pathogenic bacteria that are of high scientific and public health interest, yet which also display great potential for the development of new diagnostic, prophylactic and therapeutic procedures.<br> The authors cover all aspects of pathogenomics, including methods, genomics and applications. In addition, the ongoing development of genome, transcriptome, proteome and bioinformatic analyses of pathogenic microorganisms and their host interactions makes for a comprehensive introduction to the field of modern genomic analysis. <br> This result is invaluable to researchers and students wishing to gain a general overview of microbial functional genome analysis and pathogenesis, while also representing a good starting point for those new to the area.
INTRODUCTION<br> METHODS<br> Bioinformatics <br> Transcriptome analysis<br> Proteome analysis<br> Mutational analysis / in vivo tests<br> GENOMICS OF PATHOGENIC BACTERIA<br> Enterobacteria<br> Streptococci /<br> Enterococci<br> Staphylococci<br> Mycobacteria<br> Neisseria<br> Pseudomonas (human pathogens)<br> Clostridia /<br> Bacillus<br> Rickettsia /<br> Bartonella<br> Xanthomonas / plant pathogenic bacteria<br> GENOMICS OF PATHOGENS AND THER HOSTS -<br> APPLICATIONS<br> Virogenomics<br> Genomics of pathogenic fungi<br> Genomics of pathogenic parasites<br> Model host systems<br> Expression analysis of human genes during infection<br> Application, new diagnostic tools<br> New antibiotics<br> Reversed vaccinology<br> Genomics and bioterror<br>
"... In any case, as a snapshot of current knowledge, it is a comprehensive treatment of the field, and would prove unseful in any research environment with an interest in infectious diseases."<br> chemmedchem<br> <br>
Jörg Hacker studied biology and performed his doctoral thesis at the Martin-Luther-University of Halle in 1979. He was appointed as Associate Professor in the year 1988 and as Full Professor and Chair for Molecular Biology of Infectious Diseases at the University of Würzburg in 1993. His research interests center on the analysis of pathogenic bacteria and their host organisms, and his laboratory described the first pathogenicity islands as early as the start of the nineties. Jörg Hacker is a member of numerous academies and scientific societies and holds positions on several research bodies. He has received many awards, and was made Honorary Doctor by the University of Umea, Sweden, in 2002 and by the University of Pecs, Hungary, in 2004.<br> <br> Ulrich Dobrindt graduated with a degree in biology from the University of Göttingen (1995) and a PhD in microbiology (1999) from the University of Würzburg. He received a PhD scholarship from the Boehringer Ingelheim Fonds, and went on to carry out research on gene regulation in uropathogenic E. coli before becoming group leader of the Pathogenic Enterobacteria group at the Institute for Molecular Biology of Infectious Diseases working on enterobacterial genome plasticity focusing on extraintestinal pathogenic E. coli.<br> <br> <br>
Infectious diseases, caused by many bacteria, are still a serious threat to man and animals, even in developed countries. Besides their virulence, many pathogens gain multiple resistance to drugs that makes them almost -- or even completely -- untreatable using common antibiotics.<br> This first book to cover the highly dynamic and expanding topic adopts a comprehensive, interdisciplinary approach to focus on those pathogenic bacteria that are of high scientific and public health interest, yet which also display great potential for the development of new diagnostic, prophylactic and therapeutic procedures.<br> The authors cover all aspects of pathogenomics, clearly divided into sections on methods, genomics and applications. In addition, the ongoing development of genome, transcriptome, proteome and bioinformatic analyses of pathogenic microorganisms and their host interactions makes for a comprehensive introduction to the field of modern genomic analysis. <br> This result is invaluable to researchers and students wishing to gain a general overview of microbial functional genome analysis and pathogenesis, while also representing a good starting point for those new to the area.

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