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List of Contributors <p>Preface</p> <p>Acknowledgements</p> <p>1. Introduction</p> <p>General Introduction</p> <p>Epidemiology</p> <p>Prevention Treatment Strategies</p> <p>Terminology</p> <p>Summary</p> <p>References</p> <p>2. Structure and Function of Oral Mucosa</p> <p>Introduction</p> <p>Applied Anatomy of the Oral Cavity</p> <p>Function of the Oral Mucosa</p> <p>The Microanatomy of Oral Mucosa</p> <p>Regional Variation of Oral Mucosa</p> <p>Oral Epithelial Cell Kinetics</p> <p>Oral Epithelial Cell Proliferative Activity</p> <p>Anatomical Site Predilection for Oral Carcinogenesis</p> <p>Summary</p> <p>References</p> <p>3. Oral Carcinogenesis</p> <p>Introduction</p> <p>Oral Cancer and Precancer</p> <p>The ‘Progression Model’ for Oral Cancer</p> <p>Aetiology and Risk Factors</p> <p>Patient and Risk Factor Profiling</p> <p>Summary</p> <p>References</p> <p>4. Clinical Presentation of Oral Precancer</p> <p>Introduction</p> <p>Clinical Terminology</p> <p>Precancerous (Premalignant) Lesions</p> <p>Precancerous (Premalignant) Conditions</p> <p>Multiple Lesion Disease</p> <p>Summary</p> <p>References</p> <p>5. Diagnostic Methods</p> <p>Introduction</p> <p>Screening</p> <p>Clinical Examination Techniques</p> <p>Vital Tissue Staining</p> <p>Light Based Detection Systems</p> <p>Brush Biopsy and Exfoliative Cytology</p> <p>Clinical Diagnosis in Practice</p> <p>Summary</p> <p>References</p> <p>6. Pathological Aspects of Oral Precancer</p> <p>Introduction</p> <p>Biopsy Techniques</p> <p>The Role of the Pathologist</p> <p>Histopathological Features of Oral Potentially Malignant Disorders</p> <p>Grading of Dysplasia</p> <p>Limitations in Conventional Pathological Techniques</p> <p>Summary</p> <p>References</p> <p>7. Management of Oral Precancer</p> <p>Introduction</p> <p>Risk Factor Modification</p> <p>Observation versus Intervention</p> <p>Medical Treatment</p> <p>Surgical Treatment</p> <p>Interventional Laser Surgery</p> <p>Combined Treatment Modalities</p> <p>Patient Follow Up and Surveillance</p> <p>Summary</p> <p>References</p> <p>8. Clinical Outcome</p> <p>Introduction</p> <p>Clinical Outcome Studies</p> <p>Patient Cohort Studies</p> <p>Definitions of Clinical Outcome</p> <p>Newcastle Patient Cohort Studies</p> <p>Patient Follow Up</p> <p>Prediction of Clinical Outcome</p> <p>Summary</p> <p>References</p> <p>9. Malignant Transformation and Oral Cancer Development</p> <p>Introduction</p> <p>The Risk of Progression to Oral Carcinoma</p> <p>Malignant Transformation versus Oral Cancer Development</p> <p>Interventional Laser Surgery and Oral Cancer Prevention</p> <p>The Newcastle 10 Year Follow Up Study</p> <p>High and Low Risk Patients</p> <p>Clinical Signs of Oral Squamous Cell Carcinoma</p> <p>Diagnosis and Management of ‘Unexpected Malignancy’</p> <p>Prognosis for the ‘Transformed Patient’</p> <p>Summary</p> <p>References</p> <p>10. The Future</p> <p>Introduction</p> <p>Prevention of Oral Precancer</p> <p>Early Diagnosis of Potentially Malignant Disease</p> <p>Interventional Management Strategies in the Future</p> <p>Individualised Patient Treatments – Biomarkers and Targeted Chemoprevention</p> <p>Future Research Directions</p> <p>Summary</p> <p>References</p> <p>11. Case Histories</p> <p>Introduction</p> <p>Diagnosis of Unexpected Malignancy</p> <p>Multiple Lesion Disease Responding to Conservative Management</p> <p>Multiple Lesion Disease Requiring Repeated Laser Treatments</p> <p>Proliferative Verrucous Leukoplakia</p> <p>Localised Oral Lichenoid Reaction</p> <p>Multiple Oral Lichenoid Reactions</p> <p>Widespread Dysplastic Oral Lichenoid Reactions</p> <p>An Immunosuppressed Patient</p> <p>Chronic Hyperplastic Candidosis</p> <p>Tobacco Associated Hyperkeratosis</p> <p>Malignant Transformation in Longstanding Non-erosive Lichen Planus</p> <p>Summary</p> <p>12. Conclusions</p> <p>Oral Cancer Potentially Malignant Disorders</p> <p>Clinical Management</p> <p>Patient Care Pathways</p> <p>Public Health Strategies</p> <p>Future Directions</p> <p>Index</p>

<p>“I would highly recommend the book for those wishing to expand their knowledge on oral malignancy at a specialist trainee or higher level.”  (<i>British Dental Journal</i>, 12 October 2013)</p>

Peter Thomson is Professor of Oral and Maxillofacial Surgery at Newcastle University and <br />Honorary Consultant in Oral and Maxillofacial Surgery at Newcastle upon Tyne Hospitals NHS Foundation Trust. In recognition of his research into oral cancer & precancer, he has been awarded both a Hunterian Professorship from the Royal College of Surgeons of England & a King James IV Professorship from the Royal College of Surgeons in Edinburgh.

This pioneering book brings together the latest research on precancer conditions of the oral cavity and their specific application to the dental field. In addition to providing a scientific and evidence-based survey of the disparate sources of oral precancer research, this book presents practical information, proposing a rational basis for an interventional clinical management protocol. It will be an invaluable resource for dental practitioners as well as specialists in oral medicine and oral and maxillofacial surgery. <p>Written and edited by prominent researchers in the field, Oral Precancer furnishes its readers with a balanced approach to this highly topical subject and delivers a concise summary of the current understanding of the nature and behaviour of potentially malignant oral disorders.</p> <p>KEY FEATURES<br /> • Compiles recent research on precancer conditions of the oral cavity<br /> • Provides practical information for dentists seeking to apply research in clinical scenarios<br /> • Includes reference sections in each chapter listing relevant review articles<br /> • Contains a chapter devoted to illustrative case histories<br /> • Full of high quality colour clinical photos</p>

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