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List of Contributors, vii <p>Preface, ix</p> <p><b>Part I Pathology and Diagnosis, 1</b></p> <p>1 Disease Pathogenesis, 3<br /> <i>Roopali Gandhi and Howard L. Weiner</i></p> <p>2 Biomarkers, 26<br /> <i>Manuel Comabella and Samia J. Khoury</i></p> <p>3 Epidemiology and Genetics, 56<br /> <i>Philip L. De Jager</i></p> <p>4 Diagnosis, 77<br /> <i>James M. Stankiewicz, Varun Chaubal, and Guy J. Buckle</i></p> <p>5 Pediatric Multiple Sclerosis and Acute Disseminated Encephalomyelitis, 101<br /> <i>Tanuja Chitnis</i></p> <p>6 Magnetic Resonance Imaging in Multiple Sclerosis, 136<br /> <i>Mohit Neema, Antonia Ceccarelli, Jonathan S. Jackson, and Rohit Bakshi</i></p> <p>7 Predicting Clinical Course, 163<br /> <i>Brian Healy and Maria Liguori</i></p> <p><b>Part II Management, 181</b></p> <p>8 Medication Treatment in Multiple Sclerosis, 183<br /> <i>James M. Stankiewicz and Samia J. Khoury</i></p> <p>9 Symptom Management, 213<br /> <i>Lynn Stazzone and Brandon Brown</i></p> <p>10 Cognitive Dysfunction in Multiple Sclerosis, 239<br /> <i>Bonnie I. Glanz and Maria K. Houtchens</i></p> <p>11 Depression and Other Psychosocial Issues in Multiple Sclerosis, 263<br /> <i>David J. Rintell</i></p> <p>12 Future Therapeutic Approaches, 283<br /> <i>Howard L. Weiner and Laura Edwards</i></p> <p>Index, 301</p>

<i>Edited by<br /> </i><b>Howard L. Weiner, MD,</b> Harvard Medical School, Brigham and Women's Hospital & Partners MS Center, Boston, MA, USA<br /> <b>James M. Stankiewicz, MD,</b>  Harvard Medical School, Brigham and Women’s Hospital & Partners MS Center, Boston, MA, USA<br />

<b>Multiple Sclerosis: a complex disease requiring sophisticated management<br /> </b> Multiple Sclerosis poses labyrinthine challenges. There is no blood test to rely on for diagnosis; clinical acumen is essential. Yet an effective diagnosis only takes you part of the way: treatment offers further enigmas. The MS treatment landscape is complicated, and will become even more so with time.<br /> <br /> <p><i>Multiple Sclerosis: Diagnosis and Therapy</i> is the map you need to navigate this maze. Written and edited by leaders in the field, it guides you towards effective and positive choices for your patients. The diagnosis section provides state-of-the-art thinking about pathogenesis. With clear coverage of biomarkers, genetics, and imaging, it presents a coherent framework for making the correct diagnosis. The management section comprehensively covers current and future treatments to steer you through the many options for</p> <p>• Symptom management<br /> • Cognitive dysfunction<br /> • Depression and other mental health issues  </p> <p>‘Top Tips’ throughout provide the practical guidance you need for the best management of your patients.</p> <p><i>Multiple Sclerosis: Diagnosis and Therapy</i> should be on the bookshelf of anyone who treats patients with multiple sclerosis.</p>

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