Molecular Mechanisms Influencing Aggressive Behaviours
Novartis Foundation Symposia, Band 268 1. Aufl.
This book features scientists from a broad spectrum of disciplines discussing recent data on aggression in laboratory animals with particular reference to possible implications for understanding human aggression. Chapters focus on the major current experimental issues in the study of aggression in humans and animals. The extensive discussions deal with specific problems of interpretation at the molecular level, as well as general issues relating to our understanding of human and animal aggression.
Symposium on Molecular mechanisms influencing aggressive behaviours, held at the Novartis Foundation, London, 20-22 July. Editors :Gregory Bock (Organizer) and Jamie Goode. This meeting was based on a proposal made by Donald Pfaff, Barry Keverne and Randy Nelson. Introduction (Donald Pfaff). Some suggestions for revitalizing aggression research (Robert J. Blanchard and D. Caroline Blanchard). Aggressive behaviour: contributions from genes on the Y chromosome (Robin Lovell-Badge). Androgen receptor and molecular mechanisms of male-specific gene expression (Diane M. Robins). Quantitative trait locus analysis of aggressive behaviours in mice (Edward S. Brodkin). Genes for sex hormone receptors controlling mouse aggression (Donald Pfaff, Elena Choleris and Sonoko Ogawa). General discussion I. Molecular architecture of pheromone sensing in mammals (Catherine Dulac). Serotonergic gene inactivation in mice: models for anxiety and aggression? (Klaus-Peter Lesch). Effects of nitric oxide on the HPA axis and aggression (Randy J.Nelson). General discussion II. Serotonergic mechanisms in aggression (Berend Olivier). Vasopressin/oxytocin and aggression (Craig F. Ferris). Typology of human aggression and its biological control (Manuela Martinez and Concepcion Blasco-Ros). Aggression and social behaviour in rhesus monkeys (Stephen J. Suomi). The role of monoamine oxidase A (MAOA) in the aetiology of antisocial behaviour: the importance of gene environment interactions (Ian W. Craig). Final discussion. Index of contributors. Subject index.
"This is an excellent review of the current state of neurobiological research on aggression…should be essential reading for any scientist working in the field." (Doody's Health Services)
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
The experimental analysis of aggression has been of interest to scientists for a long time and there have been many interdisciplinary studies of aggression in both animals and humans. However, during the past five years or so, the application of new molecular genetic techniques has enabled us to explore mechanisms of aggression in ways that were not previously possible, yielding new information and insights. This book features leading scientists from a broad spectrum of disciplines describing and discussing recent data on aggression in laboratory animals. Particular emphasis is placed on possible implications for understanding human aggression. Chapters cover the major current experimental issues in the study of aggression in humans and animals: sex differences in aggression and related hormonal effects; specific genes for neurotransmitters, neuropeptides and nitric oxide; and finally aggression in primates, both human and animal. The discussions published here deal with the specific problems of interpretation at the molecular level and also with general issues relating to our understanding of human and animal aggression. This important book provides a comprehensive account of our current understanding of the underlying biology of aggression in humans and animals. It should prove invaluable to researchers in various branches of both neuroscience and psychology.
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