<p>Contributors, viii</p> <p>Foreword, xiii</p> <p>Preface, xiv</p> <p>About the Companion Website, xvi</p> <p><b>Part I Overview: Clinical Fundamentals of Hepatology</b></p> <p>1 History Taking and Physical Examination for the Patient with Liver Disease, 3<br /><i>Esperance A. Schaefer and Lawrence S. Friedman</i></p> <p>2 Laboratory Tests, Noninvasive Markers of Fibrosis, Liver Biopsy, and Laparoscopy, 17<br /><i>Michael P. Curry and Lennox J. Jeffers</i></p> <p>3 Noninvasive and Invasive Imaging of the Liver and Biliary Tract, 38<br /><i>Koushik K. Das, Matthew A.Morgan, and Gregory G. Ginsberg</i></p> <p><b>Part II General Considerations</b></p> <p>4 Physioanatomic Considerations, 73<br /><i>Ian R. Wanless</i></p> <p>5 Bilirubin Metabolism and Jaundice, 103<br /><i>Allan W. Wolkoff and Paul D. Berk</i></p> <p>6 Hepatic Histopathology, 135<br /><i>Zachary D. Goodman</i></p> <p>7 Mechanisms of Liver Injury, 200<br /><i>Harmeet Malhi and Gregory J. Gores</i></p> <p>8 Hepatic Manifestations of Systemic Disorders, 218<br /><i>Stuart C. Gordon and Humberto C. Gonzalez</i></p> <p>9 The Liver in Pregnancy, 244<br /><i>Nancy Reau and Yannick Bacq</i></p> <p><b>Part III Consequences of Liver Disease</b></p> <p>10 Hepatic Fibrosis, 271<br /><i>Scott L. Friedman</i></p> <p>11 Preoperative Evaluation of the Patient with Liver Disease, 290<br /><i>Patrick S. Kamath and Mark T. Keegan</i></p> <p>12 Management of Portal Hypertension, 304<br /><i>Guadalupe Garcia-Tsao and Juan G. Abraldes</i></p> <p>13 Renal Complications of Liver Disease and the Hepatorenal Syndrome, 336<br /><i>Xingxing S. Cheng and W. Ray Kim</i></p> <p>14 Pulmonary Manifestations of Liver Disease, 353<br /><i>Michael B. Fallon and Anil Seetharam</i></p> <p>15 Ascites and Spontaneous Bacterial Peritonitis, 365<br /><i>Vicente Arroyo and Javier Fern´andez</i></p> <p>16 Hepatic Encephalopathy, 387<br /><i>Chathur Acharya and Jasmohan S. Bajaj</i></p> <p>17 Acute Liver Failure, 411<br /><i>Robert J. Fontana and Khurram Bari</i></p> <p>18 Acute-on-Chronic Liver Failure, 432<br /><i>Florence Wong</i></p> <p>19 Malnutrition and Liver Disease, 460<br /><i>Craig McClain, Irina Kirpich, and Laura Smart</i></p> <p><b>Part IV Cholestatic Disorders</b></p> <p>20 Primary Sclerosing Cholangitis, 491<br /><i>John M. Vierling</i></p> <p>21 Primary Biliary Cholangitis, 523<br /><i>Cynthia Levy, Andres F. Carrion, and Marlyn J. Mayo</i></p> <p>22 Autoimmune Hepatitis, 546<br /><i>Gideon M. Hirschfield and Gwilym J. Webb</i></p> <p><b>Part V Viral Hepatitis</b></p> <p>23 Hepatitis A and E, 565<br /><i>Kenneth E. Sherman and Shyam Kottilil</i></p> <p>24 Hepatitis B and D, 584<br /><i>Marc G. Ghany and Naveen Gara</i></p> <p>25 Hepatitis C, 628<br /><i>Michael W. Fried, Jama M. Darling, and Stanley M. Lemon</i></p> <p><b>Part VI Alcohol- and Drug-induced Liver Disease</b></p> <p>26 Alcoholic Liver Disease, 701<br /><i>Mack C. Mitchell and Gyongyi Szabo</i></p> <p>27 Drug-induced Hepatotoxicity, 740<br /><i>Dominique Larrey, Jose Ursic-Bedoya, and Lucy Meunier</i></p> <p>28 Mechanisms of Drug-induced Liver Injury, 774<br /><i>Paul B. Watkins and Merrie Mosedale</i></p> <p><b>Part VII Genetic and Metabolic Disease</b></p> <p>29 Wilson Disease, 801<br /><i>Michael L. Schilsky and Aftab Ala</i></p> <p>30 Hemochromatosis and Iron Storage Disorders, 820<br /><i>Kris V. Kowdley and Priya Handa</i></p> <p>31 Alpha-1 Antitrypsin Deficiency, 843<br /><i>David H. Perlmutter</i></p> <p>32 Nonalcoholic Fatty Liver Disease, 867<br /><i>Curtis K. Argo, Zachary H. Henry, and Stephen H. Caldwell</i></p> <p><b>Part VIII Vascular Diseases of the Liver</b></p> <p>33 Vascular Liver Disease, 911<br /><i>Dominique-Charles Valla</i></p> <p>34 The Liver in Circulatory Failure, 935<br /><i>Santiago J. Munoz, Hanisha R. Manickavasagan, and Idean Amirjazil</i></p> <p><b>Part IX Benign and Malignant Tumors; Cystic Disorders</b></p> <p>35 Benign Tumors, Nodules, and Cystic Diseases of the Liver, 949<br /><i>Julien Calderaro and Jessica Zucman-Rossi</i></p> <p>36 Hepatocellular Carcinoma, 977<br /><i>Maddie Kubiliun and Jorge A. Marrero</i></p> <p>37 Surgical Options in Liver Cancers, 989<br /><i>Garrett R. Roll and John Paul Roberts</i></p> <p><b>Part X Infectious and Granulomatous Disease</b></p> <p>38 Amoebic and Pyogenic Liver Abscesses, 1005<br /><i>Marco A. Olivera-Mart´ınez and David Kershenobich</i></p> <p>39 Parasitic Diseases, 1013<br /><i>Michael A. Dunn</i></p> <p>40 Granulomas of the Liver, 1028<br /><i>James H. Lewis</i></p> <p><b>Part XI Elements of Liver Transplantation</b></p> <p>41 Selection of Candidates and Timing of Liver Transplantation, 1055<br /><i>Meaghan Phipps, Alyson N. Fox, and Robert S. Brown Jr.</i></p> <p>42 Immunosuppression: The Global Picture, 1065<br /><i>Caroline C. Jadlowiec, Timucin Taner, and Russell H. Wiesner</i></p> <p>43 The First Six Months Following Liver Transplantation, 1079<br /><i>K. Rajender Reddy and Manuel Mendizabal</i></p> <p>44 Long-term Management of the Liver Transplant Patient, 1093<br /><i>Timothy M. McCashland</i></p> <p>45 The Liver Transplant Procedure, 1107<br /><i>Bijan Eghtesad, Koji Hashimoto, and John Fung</i></p> <p>46 Recurrent Disease Following Liver Transplantation, 1127<br /><i>Haripriya Maddur and Josh Levitsky</i></p> <p>47 The Role of Retransplantation, 1143<br /><i>Peter L. Abt and Kim M. Olthoff</i></p> <p>48 Controversies in Liver Transplantation, 1156<br /><i>James F. Trotter</i></p> <p>Index, 1169</p>