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<p>Contributors vii</p> <p>Preface xv</p> <p>Acknowledgments xvii</p> <p>Foreword xix</p> <p><b>Section 1 Bones of the oral-dental and craniofacial complex 1</b></p> <p>1 Embryology of craniofacial bones 3<br /> <i>Antonio Nanci and Pierre Moffatt</i></p> <p>2 Clinical correlate: cleft lip and palate 13<br /> <i>Emily R. Gallagher and Joel Berg</i></p> <p>3 Cell and molecular biology of the osteoclast and bone resorption 17<br /> <i>Martin Biosse-Duplan, William C. Horne, and Roland Baron</i></p> <p>4 Clinical correlate: osteopetrosis 29<br /> <i>Paul C. Edwards and Nasser Said-Al-Naief</i></p> <p>5 Clinical correlate: CLCN7-associated autosomal recessive osteopetrosis 35<br /> <i>Piranit Nik Kantaputra</i></p> <p>6 Osteoblasts of craniofacial bone 43<br /> <i>Renny T. Franceschi, Chunxi Ge, and Christopher G. Wilson</i></p> <p>7 Clinical correlate: cleidocranial dysplasia 59<br /> <i>Shu Takeda, Nobuhiko Haga, and Keiji Moriyama</i></p> <p>8 Cell biology of craniofacial bone: osteocytes 63<br /> <i>Lynda F. Bonewald</i></p> <p>9 Clinical correlate: Van Buchem disease 71<br /> <i>H.-J. Prins, A.L.J.J. Bronckers, and J. Klein-Nulend</i></p> <p>10 Stem cell biology in the craniofacial apparatus 79<br /> <i>Carolina Parada, Kentaro Akiyama, Yang Chai, and Songtao Shi</i></p> <p>11 Clinical correlate: stem cell therapy for craniofacial bone regeneration 93<br /> <i>Giorgio Pagni, William V. Giannobile, and Darnell Kaigler</i></p> <p>12 Extracellular matrix and mineralization of craniofacial bone 99<br /> <i>Marc D. McKee, Monzur Murshed, and Mari T. Kaartinen</i></p> <p>13 Clinical correlate: osteogenesis imperfecta 111<br /> <i>Peter H. Byers</i></p> <p><b>Section 2 Teeth 117</b></p> <p>14 Tooth development 119<br /> <i>Irma Thesleff and Emma Juuri</i></p> <p>15 Clinical correlate: tooth agenesis 129<br /> <i>Rena N. D’Souza and Gabriele I. Mues</i></p> <p>16 Dentin 135<br /> <i>Chunlin Qin and Jian Q. Feng</i></p> <p>17 Clinical correlate: dentinogenesis imperfecta, restorative procedures, and caries 143Yong-<i>Hee Patricia Chun and Jan CC. Hu</i></p> <p>18 Enamel fabrication: the story of amelogenesis 153<br /> <i>Carolyn W. Gibson and Malcolm L. Snead</i></p> <p>19 Clinical correlate: amelogenesis imperfecta 163<br /> <i>Rochelle G. Lindemeyer</i></p> <p>20 Cementum 169<br /> <i>Brian L. Foster and Martha J. Somerman</i></p> <p>21 Clinical correlate: case study of identical twins with cementum and periodontal defects resulting from odontohypophosphatasia 183<br /> <i>Thaisângela L. Rodrigues, Ana Paula Georgetti, Luciane Martins, João S. Pereira Neto, Brian L. Foster, and Francisco H. Nociti Jr.</i></p> <p>22 Dental engineering: tooth regeneration 191<br /> <i>Weibo Zhang and Pamela C. Yelick</i></p> <p>23 Clinical correlate: periodontal regeneration 201<br /> <i>Jia-Hui Fu and Hom-Lay Wang</i></p> <p>24 Clinical correlate: natural tooth regeneration 207<br /> <i>Gary E. Heyamoto</i></p> <p>25 Clinical correlate: regenerative endodontics in an immature tooth with pulpal necrosis and<br /> periapical pathosis 211<br /> <i>Tatiana M. Botero, Christine M. Sedgley, Martha I. Paniagua, and Diego M. Tobón</i></p> <p><b>Section 3 Bones and teeth 217</b></p> <p>26 Bone and tooth interface: periodontal ligament 219<br /> <i>P. Mark Bartold</i></p> <p>27 Clinical correlate: two cases of destructive periodontal disease 231<br /> <i>Rahime Meral Nohutcu</i></p> <p>28 Periodontal disease and infl ammationinduced bone remodeling 237<br /> <i>Dana T. Graves, Elliot D. Rosenstein, Carlos Rossa Jr., and Joseph P. Fiorellini</i></p> <p>29 Clinical correlate: endodontic lesions 249<br /> <i>Matthew DiAndreth and Hongjiao Ouyang</i></p> <p>30 Biomechanics of teeth in bone: function, movement, and prosthetic rehabilitation 255<br /> <i>Susan W. Herring</i></p> <p>31 Clinical correlate: biomechanics of teeth in bone 269<br /> <i>Gregory King, Geoffrey Greenlee, Paola Leone, and Gregory Vaughn</i></p> <p>32 Impact of metabolic bone disease on craniofacial bones and teeth 277<br /> <i>Jill Bashutski, L. Susan Taichman, and Laurie K. McCauley</i></p> <p>33 Clinical correlate: renal osteodystrophy 291<br /> <i>Flavia Pirih, Gabriella Tehrany, and Tara Aghaloo</i></p> <p>34 Mineral metabolism and its impact on craniofacial bones and teeth 297<br /> <i>Jian Q. Feng and Chunlin Qin</i></p> <p>35 Clinical correlate: mineral metabolism and disruption of dentoalveolar development in a case of craniometaphyseal dysplasia (CMD) 305<br /> <i>Hai Zhang and Brian Foster</i></p> <p>36 Sun, nutrition, and the mineralization of bones and teeth 311<br /> <i>Philippe P. Hujoel</i></p> <p>37 Clinical correlate: vitamin D deficiency 327<br /> <i>Ana Lucia Seminario and Elizabeth Velan</i></p> <p>38 Impact of therapeutic modalities on craniofacial bones and teeth 331<br /> <i>Purnima S. Kumar and Angelo Mariotti</i></p> <p>39 Clinical correlate: osteoradionecrosis of the jaws (ORN) 343<br /> <i>Nicholas M. Makhoul and Brent B. Ward</i></p> <p>Index 349</p> <p>Figures from the book are available for download at www.wiley.com/go/mccauley</p>

<p>“Notwithstanding these minor points, the book is very well structured and provides a comprehensive overview of all the mineralized tissues in in the craniofacial complex, with interesting aspects of the requirements for successful clinical applications.”  (<i>Implant Dentistry</i>, 1 June 2013)</p> <p>“In summary , this book is commendable  for the extent of its content and its ability to remain up to date.   It serves the needs not only of first-year students , but also of various specialists in training and all practitioners looking for a rationale in their diagnosis and treatment.”  (<i>British Dental Journal</i>, 8 December 2012)</p> <p> </p>

<p><b>Laurie K. McCauley</b>, DDS, PhD is the William K. and Mary Anne Najjar Professor and Chair of the Department of Periodontics and Oral Medicine, and Professor in the Department of Pathology at the University of Michigan in Ann Arbor, Michigan.</p> <p><b>Martha J. Somerman</b>, DDS, PhD, formerly Dean and Professor, University of Washington School of Dentistry, is currently the Director of the National Institute of Dental and Craniofacial Research, and Chief, Laboratory for Oral Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health in Bethesda, Maryland.</p>

<i>Mineralized Tissues in Oral and Craniofacial Science</i> is a major comprehensive update on knowledge in the field of mineralized tissues in the oral and craniofacial region. Drs. McCauley and Somerman assembled an international team of researchers and clinicians, offering a global perspective on the current knowledge in this field. Basic and clinical correlates reinforce the significance of research to clinical diagnoses and therapies, written in a manner that lends easily to their use for case study teaching venues.<br /> <br /> <p>Section 1 features the many aspects of bone in the craniofacial region, including embryology, cell biology, and stem cell biology. Section 2 focuses on teeth-tooth development, dentin, enamel, cementum, and tooth regeneration. Section 3 discusses the interaction between bones and teeth, including those associated with inflammatory processes, periodontal ligaments, biomechanics, and other impact factors-such as nutrition, metabolic bone diseases and therapeutic modalities.</p> The novel approach of linking the basic principles of the cell and molecular biology of hard tissues to clinical correlates will appeal to readers at all levels of their research careers, both students and faculty; faculty interested in a comprehensive text for reference; and  clinicians interested in the biologic aspects of bones and teeth.

SG