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Foreword ix<br /> <i>Sir David Baulcombe</i> <p>Preface xi</p> <p>Contributors xiii</p> <p>1 MICRORNAS: A BRIEF INTRODUCTION 1<br /> <i>Charles H. Lawrie</i></p> <p><b>PART I: MICRORNAS AS PHYSIOLOGICAL REGULATORS 25</b></p> <p>2 MICRORNA REGULATION OF STEM CELL FATE AND REPROGRAMMING 27<br /> <i>Erika Lorenzo Vivas, Gustavo Tiscornia, and Juan Carlos Izpisua Belmonte</i></p> <p>3 MICRORNAS AS REGULATORS OF IMMUNITY 41<br /> <i>Donald T. Gracias and Peter D. Katsikis</i></p> <p>4 REGULATION OF SENESCENCE BY MICRORNAS 59<br /> <i>Ioannis Grammatikakis and Myriam Gorospe</i></p> <p>5 THE EMERGENCE OF GEROMIRS: A GROUP OF MICRORNAS IMPLICATED IN AGING 77<br /> <i>Alejandro P. Ugalde, Agnieszka Kwarciak, Xurde M. Caravia, Carlos López-Otín, and Andrew J. Ramsay</i></p> <p>6 MICRORNAS AND HEMATOPOIESIS 91<br /> <i>Sukhinder K. Sandhu and Ramiro Garzon</i></p> <p>7 MICRORNAS IN PLATELET PRODUCTION AND ACTIVATION 101<br /> <i>Leonard C. Edelstein, Srikanth Nagalla, and Paul F. Bray</i></p> <p><b>PART II: MICRORNAS IN INFECTIOUS DISEASE: HOST–PATHOGEN INTERACTIONS 117</b></p> <p>8 MICRORNAS AS KEY PLAYERS IN HOST-VIRUS INTERACTIONS 119<br /> <i>Aurélie Fender and Sébastien Pfeffer</i></p> <p>9 MICRORNA EXPRESSION IN AVIAN HERPESVIRUSES 137<br /> <i>Yongxiu Yao and Venugopal Nair</i></p> <p>10 FUNCTION OF HUMAN CYTOMEGALOVIRUS MICRORNAS AND POTENTIAL ROLES IN LATENCY 153<br /> <i>Natalie L. Reynolds, Jon A. Pavelin, and Finn E. Grey</i></p> <p>11 INVOLVEMENT OF SMALL NON-CODING RNA IN HIV-1 INFECTION 165<br /> <i>Guihua Sun, John J. Rossi, and Daniela Castanotto</i></p> <p>12 MICRORNA IN MALARIA 183<br /> <i>Panote Prapansilp and Gareth D.H. Turner</i></p> <p><b>PART III: CANCER 199</b></p> <p>13 THE MICRORNA DECALOGUE OF CANCER INVOLVEMENT 201<br /> <i>Tanja Kunej, Irena Godnic, Minja Zorc, Simon Horvat, and George A. Calin</i></p> <p>14 MICRORNAS AS ONCOGENES AND TUMOR SUPPRESSORS 223<br /> <i>Eva E. Rufi no-Palomares, Fernando J. Reyes-Zurita, Jose Antonio Lupiáñez, and Pedro P. Medina</i></p> <p>15 LONG NON-CODING RNAS AND THEIR ROLES IN CANCER 245<br /> <i>Yolanda Sánchez and Maite Huarte</i></p> <p>16 REGULATION OF HYPOXIA RESPONSES BY MICRORNA EXPRESSION 267<br /> <i>Carme Camps, Adrian L. Harris, and Jiannis Ragoussis</i></p> <p>17 CONTROL OF RECEPTOR FUNCTION BY MICRORNAS IN BREAST CANCER 287<br /> <i>Claudia Piovan and Marilena V. Iorio</i></p> <p>18 MICRORNAS IN HUMAN PROSTATE CANCER: FROM PATHOGENESIS TO THERAPEUTIC IMPLICATIONS 311<br /> <i>Mustafa Ozen and Omer Faruk Karatas</i></p> <p>19 MICRORNA SIGNATURES AS BIOMARKERS OF COLORECTAL CANCER 329<br /> <i>Katrin Pfütze, Xiaoya Luo, and Barbara Burwinkel</i></p> <p>20 GENETIC VARIATIONS IN MICRORNA-ENCODING SEQUENCES AND MICRORNA TARGET SITES ALTER LUNG CANCER SUSCEPTIBILITY AND SURVIVAL 343<br /> <i>Ming Yang and Dongxin Lin</i></p> <p>21 MICRORNA IN MYELOPOIESIS AND MYELOID DISORDERS 353<br /> <i>Sara E. Meyer and H. Leighton Grimes</i></p> <p>22 MICRORNA DEREGULATION BY ABERRANT DNA METHYLATION IN ACUTE LYMPHOBLASTIC LEUKEMIA 371<br /> <i>Xabier Agirre and Felipe Prósper</i></p> <p>23 ROLE OF MIRNAS IN THE PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA 383<br /> <i>Veronica Balatti, Yuri Pekarsky, Lara Rizzotto, and Carlo M. Croce</i></p> <p>24 MICRORNA IN B-CELL NON-HODGKIN’S LYMPHOMA: DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS 403<br /> <i>Nerea Martínez, Lorena Di Lisio, and Miguel Angel Piris</i></p> <p>25 MICRORNAS IN DIFFUSE LARGE B-CELL LYMPHOMA 419<br /> <i>Izidore S. Lossos and Alvaro J. Alencar</i></p> <p>26 THE ROLE OF MICRORNAS IN HODGKIN’S LYMPHOMA 435<br /> <i>Wouter Plattel, Joost Kluiver, Arjan Diepstra, Lydia Visser, and Anke van den Berg</i></p> <p>27 MICRORNA EXPRESSION IN CUTANEOUS T-CELL LYMPHOMAS 449<br /> <i>Cornelis P. Tensen</i></p> <p><b>PART IV: HEREDITARY AND OTHER NON-INFECTIOUS DISEASES 463</b></p> <p>28 MICRORNAS AND HEREDITARY DISORDERS 465<br /> <i>Matías Morín and Miguel A. Moreno-Pelayo</i></p> <p>29 MICRORNAS AND CARDIOVASCULAR DISEASES 477<br /> <i>Koh Ono</i></p> <p>30 MICRORNAS AND DIABETES 495<br /> <i>Romano Regazzi</i></p> <p>31 MICRORNAS IN LIVER DISEASES 509<br /> <b>Patricia Munoz-Garrido, Marco Marzioni, Elizabeth Hijona, Luis Bujanda, and Jesus M. Banales</b></p> <p>32 MICRORNA REGULATION IN MULTIPLE SCLEROSIS 523<br /> <i>Andreas Junker</i></p> <p>33 THE ROLE OF MICRORNAS IN ALZHEIMER’S DISEASE 539<br /> <i>Shahar Barbash and Hermona Soreq</i></p> <p>34 CURRENT VIEWS ON THE ROLE OF MICRORNAS IN PSYCHOSIS 553<br /> <i>Aoife Kearney, Javier A. Bravo, and Timothy G. Dinan</i></p> <p><b>PART V: CIRCULATING MICRORNAS AS CELLULAR MESSENGERS AND NOVEL BIOMARKERS 567</b></p> <p>35 CIRCULATING MICRORNAS AS NON-INVASIVE BIOMARKERS 569<br /> <i>Heidi Schwarzenbach and Klaus Pantel</i></p> <p>36 CIRCULATING MICRORNAS AS CELLULAR MESSENGERS 589<br /> <i>Kasey C. Vickers</i></p> <p>37 RELEASE OF MICRORNA-CONTAINING VESICLES CAN STIMULATE ANGIOGENESIS AND METASTASIS IN RENAL CARCINOMA 607<br /> <i>Federica Collino, Cristina Grange, and Giovanni Camussi</i></p> <p><b>PART VI: THERAPEUTIC USES OF MICRORNAS: CURRENT PERSPECTIVES AND FUTURE DIRECTIONS 623</b></p> <p>38 MICRORNA REGULATION OF CANCER STEM CELLS AND MICRORNAS AS POTENTIAL CANCER STEM CELL THERAPEUTICS 625<br /> <i>Can Liu and Dean G. Tang</i></p> <p>39 THERAPEUTIC MODULATION OF MICRORNAS 639<br /> <i>Achim Aigner and Hannelore Dassow</i></p> <p>40 LOCKED NUCLEIC ACIDS AS MICRORNA THERAPEUTICS 663<br /> <i>Henrik Ørum</i></p> <p>Index 673</p>

<p><strong>Dr. Charles Lawrie</strong> is Director of Oncology at the Biodonostia Institute in San Sebastián, Spain. The author of numerous research papers and book chapters, Dr. Lawrie is an Associate Editor for the <em>Journal of Cancer Research</em>, and serves on the editorial boards of a number of other prestigious journals including <em>Cancers</em>, <em>Journal of RNAi and Gene Silencing</em>, <em>American Journal of Blood</em>, and <em>ISRN Hematology</em>.

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