Details

Metalloprotein Active Site Assembly


Metalloprotein Active Site Assembly


EIC Books 1. Aufl.

von: Michael K. Johnson, Robert A. Scott

158,99 €

Verlag: Wiley
Format: EPUB
Veröffentl.: 14.08.2017
ISBN/EAN: 9781119159858
Sprache: englisch
Anzahl Seiten: 424

DRM-geschütztes eBook, Sie benötigen z.B. Adobe Digital Editions und eine Adobe ID zum Lesen.

Beschreibungen

<p><b>Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins</b></p> <p><i>Metalloprotein Active Site Assembly</i> focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved.</p> <p>An excellent companion to the earlier book in this series<i> Metals in Cells</i>—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research.</p> <p><i>Metalloprotein Active Site Assembly</i> is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.</p>
<p>Contributors ix</p> <p>Series Preface xiii</p> <p>Volume Preface xv</p> <p><b>Part 1: Assembly and Trafficking of Simple Fe-S Clusters 1</b></p> <p>Nif System for Simple [Fe–S] Cluster Assembly in Nitrogen-Fixing Bacteria 3<br /><i>Patricia C. Dos Santos and Dennis R. Dean</i></p> <p>Iron–Sulfur Cluster Assembly in Bacteria and Eukarya using the ISC Biosynthesis Machinery 17<br /><i>Sandrine Ollagnier de Choudens and Hélène Puccio</i></p> <p>The Suf System in Archaea, Bacteria, and Eukaryotic Organelles 37<br /><i>Guangchao Dong, Savannah Witcher, F. Wayne Outten and Marinus Pilon</i></p> <p>Roles of Class II Glutaredoxins in the Maturation of Fe–S Proteins 53<br /><i>Jonathan Przybyla-Toscano, Thomas Roret, Jérémy Couturier and Nicolas Rouhier</i></p> <p><b>Part 2: Assembly of Complex and Heterometallic Fe-S Cluster Active Sites 73</b></p> <p>Nitrogenase Metallocluster Assembly 75<br /><i>Nathaniel S. Sickerman, Lee A. Rettberg, Yilin Hu and Markus W. Ribbe</i></p> <p>Metallocluster Assembly: Maturation of [FeFe]-Hydrogenases 93<br /><i>Giorgio Caserta, Ludovic Pecqueur, Cecilia Papini and Marc Fontecave</i></p> <p>CO Dehydrogenase and Acetyl-CoA Synthase 111<br /><i>Holger Dobbek</i></p> <p><b>Part 3: Assembly of Homometallic and Heterometalic Cu Cluster Active Sites 123</b></p> <p>Assembly of Dinuclear Copper Center in Tyrosinases and Hemocyanins 125<br /><i>Nobutaka Fujieda and Shinobu Itoh</i></p> <p>Multicopper Oxidases 139<br /><i>Daniel J. Kosman</i></p> <p>Assembly of the Redox-Active Metal Centers of Cytochrome <i>c </i>Oxidase 157<br /><i>Eva Nyvltova, Antoni Barrientos and Jonathan Hosler</i></p> <p>CuA and CuZ Center Assembly in Nitrous Oxide Reductase 185<br /><i>Sofia R. Pauleta and Isabel Moura</i></p> <p>MoCu CO Dehydrogenase and its Active-Site Assembly 197<br /><i>Frank Mickoleit</i></p> <p><b>Part 4: Assembly of Homometallic and Heterometallic Mn Clusters 213</b></p> <p>Homo- and Heterometallic Dinuclear Manganese Proteins: Active Site Assembly 215<br /><i>Gustav Berggren, Daniel Lundin and Britt-Marie Sjöberg</i></p> <p>Biogenesis and Assembly of the CaMn<sub>4</sub>O<sub>5</sub> Core of Photosynthetic Water Oxidases and Inorganic Mutants 233<br /><i>Colin Gates, Gennady Ananyev and G. Charles Dismukes</i></p> <p><b>Part 5: Assembly of Homometallic and Heterometallic Ni Clusters 249</b></p> <p>Urease Activation 251<br /><i>Robert P. Hausinger</i></p> <p>Insights into [NiFe]-Hydrogenase Active Site Metallocluster Assembly 261<br /><i>Robert Gary Sawers and Constanze Pinske</i></p> <p><b>Part 6: Assembly of Cofactors for Binding Active-Site Metal Centers 273</b></p> <p>Moco in Mo/W Enzymes 275<br /><i>Silke Leimkühler</i></p> <p>Heme Biosynthesis 299<br /><i>Amy E. Medlock and Harry A. Dailey</i></p> <p>Siroheme Assembly and Insertion to Nitrite and Sulfite Reductase 315<br /><i>M. Elizabeth Stroupe and Martin J. Warren</i></p> <p>Biosynthesis of Coenzyme F430 and the Posttranslational Modification of the Active Site Region of Methyl-Coenzyme M Reductase 323<br /><i>Steven O. Mansoorabadi, Kaiyuan Zheng and Phong D. Ngo</i></p> <p>Coenzyme B12 Biosynthesis in Bacteria and Archaea 335<br /><i>Theodoric A. Mattes, Jorge C. Escalante-Semerena, Evelyne Deery and Martin J. Warren</i></p> <p>Crosslinked Cys–Tyr Free Radical Redox Cofactor 361<br /><i>James W. Whittaker</i></p> <p>Topaquinone Biogenesis and Lysyl Tyrosine Quinone Biogenesis in Cu Amine Oxidases 375<br /><i>David M. Dooley, Doreen E. Brown and Eric M. Shepard</i></p> <p>Index 389</p>
<p>Editors<br> <strong>Michael K. Johnson,</strong> <em>University of Georgia, Athens, GA, USA</em><br> <strong>Robert A. Scott,</strong> <em>University of Georgia, Athens, GA, USA</em>
<p> <strong>Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins</strong> <p> <em>Metalloprotein Active Site Assembly</em> focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved. <p> An excellent companion to the earlier book in this series <em>Metals in Cells</em>—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research. <p><em>Metalloprotein Active Site Assembly</em> is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics. <p> About <strong>EIBC Books</strong> <p>The <strong>Encyclopedia of Inorganic and Bioinorganic Chemistry (EIBC)</strong> was created as an online reference in 2012 by merging the <em>Encyclopedia of Inorganic Chemistry</em> and the <em>Handbook of Metalloproteins.</em> The resulting combination proves to be the defining reference work in the field of inorganic and bioinorganic chemistry, and a lot of chemistry libraries around the world have access to the online version. Many readers, however, prefer to have more concise thematic volumes in print, targeted to their specific area of interest. This feedback from EIBC readers has encouraged the Editors to plan a series of EIBC Books [formerly called EIC Books], focusing on topics of current interest. <p>EIBC Books will appear on a regular basis, will be edited by the EIBC Editors and specialist Guest Editors, and will feature articles from leading scholars in their fields. EIBC Books aim to provide both the starting research student and the confirmed research worker with a critical distillation of the leading concepts in inorganic and bioinorganic chemistry, and provide a structured entry into the fields covered.

Diese Produkte könnten Sie auch interessieren:

Lanthanide and Actinide Chemistry
Lanthanide and Actinide Chemistry
von: Simon Cotton
PDF ebook
50,99 €
Mass Spectrometry of Inorganic and Organometallic Compounds
Mass Spectrometry of Inorganic and Organometallic Compounds
von: William Henderson, J. Scott McIndoe
PDF ebook
59,99 €
Neurodegenerative Diseases and Metal Ions, Volume 1
Neurodegenerative Diseases and Metal Ions, Volume 1
von: Astrid Sigel, Helmut Sigel, Roland K. O. Sigel
PDF ebook
228,99 €