Details
Lipophilicity in Drug Action and Toxicology
Methods & Principles in Medicinal Chemistry, Band 4 1. Aufl.
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103,99 € |
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| Verlag: | Wiley-VCH |
| Format: | |
| Veröffentl.: | 26.09.2008 |
| ISBN/EAN: | 9783527614981 |
| Sprache: | englisch |
| Anzahl Seiten: | 463 |
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Beschreibungen
In keeping with the outstanding importance of lipophilicity in biosciences, this volume examines all its facets in more than twenty contributions from leading experts.<br> <br> It offers a thorough and highly topical survey of this rapidly developing field of research. Color plates demonstrating structural aspects, a vast number of references, and the straightforward presentation of the material make this volume a invaluable tool for all researchers involved in drug design or in the investigation of drug action.
From the contents:<br> Lipophilicity: The empirical tool and the fundamental objective/<br> Lipophilicity: A history/<br> Thermodynamics of van der Waals and hydrophobic interactions/<br> Intramolecular interactions encoded in lipophilicity: their nature and significance/<br> Lipophilicity measurement by reversed-phase high performance liquid chromatography (RP-HPLC)/<br> Centrifugal partition chromatography for lipophilicity measurements/<br> Assessment of distribution - pH profiles/<br> Estimation of lipophilicty by reversed-phase thin layer chromatography/<br> The future of log P calculation/<br> Theoretical calculation of partition coefficients/<br> Cellular automata model of partitioning between liquid phases
<p><b>Vladimir Pliska</b> is the editor of <i>Lipophilicity in Drug Action and Toxicology</i>, published by Wiley.</p> <p><b>Bernard Testa</b> is the editor of <i>Lipophilicity in Drug Action and Toxicology</i>, published by Wiley.</p> <p><b>Han van de Waterbeemd</b> is the editor of <i>Lipophilicity in Drug Action and Toxicology</i>, published by Wiley.</p> <p><b>Raimund Mannhold</b> is the series editor of series: <i>Methods and Principles in Medicinal Chemistry (volume: Lipophilicity in Drug Action and Toxicology)</i>, published by Wiley.</p> <p><b>Hugo Kubinyi</b> is the series editor of series: <i>Methods and Principles in Medicinal Chemistry (volume: Lipophilicity in Drug Action and Toxicology)</i>, published by Wiley.</p> <p><b>Hendrik Timmerman</b> is the series editor of series: <i>Methods and Principles in Medicinal Chemistry (volume: Lipophilicity in Drug Action and Toxicology)</i>, published by Wiley.</p>
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