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Lipid Rafts, Caveolae, and Membrane Traffic<br> The Forces that Shape Caveolae<br> The Biophysical Characterization of Lipid Rafts<br> The Role of Caveolae and Noncaveolar Rafts in Endocytosis<br> Role of Cholesterol in Signal Transduction from Caveolae<br> Phosphorylation of Caveolin and Signaling from Caveolae<br> Role of Lipid Microdomains in the Formation of Supramolecular Protein Complexes and Transmembrane Signaling<br> Caveolin and its Role in Intracellular Chaperone Complexes<br> The Roles of Caveolae and Caveolin in Cell Shape, Locomotion, and Stress Fiber Formation<br> Lipid Rafts in Trafficking and Processing of Prion Protein and Amyloid Precursor Protein<br> Caveolae and the Endothelial Nitric Oxide Synthase<br> The Role of Caveolin-1 in Tumor Cell Survival and Cancer Progression<br>

"... well written and useful chapters." <br> Natural Cell Biology<br> <br> "This is a book that will be useful to everyone interested in membrane biophysics. The chapters highlight the many unanswered questions in the field and detail some work that should be done in the future. Perhaps this book will stimulate more of us to get involved in the development of novel experimental methods and to continue trying to answer the critical unanswered questions." ChemBioChem<br> <br> "... a timely summary of our current picture of the raft concept ... clarifies some misunderstood ideas." <br> Future Medicine<br> <br> "In conclusion, this book is a delightful mix of structural biology, biophysics, cell biology, biochemistry, physiology and medicine. All researchers in biomedicine with an interest in membrane biology will find this book both informative and an excellent point of reference. Its acquisition would provide a valuable addition to the bookshelves of all who purchase it."<br> BSCB Newsletter<br>

Christopher Fielding is Neider Professor of Cardiovascular Physiology at the University of California at San Francisco (UCSF). He graduated from University College in London (UK) where he also received his PhD. After appointments at Oxford University and at the University of Chicago, he joined the faculty at UCSF in 1971, being appointed full professor in 1985.<br> Professor Fielding's main research interest is in the trafficking of cholesterol, its regulation and its role in signal transduction.<br>

This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail.<br> Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include:<br> <br> - Historical Background<br> - Distinct Structures and Functions <br> - Structural Basis <br> - Signaling <br> - Viral Entry and Virion Budding <br> - Cholesterol Transport<br> - Caveolins <br> - Lipid Shells <br> - Cell Polarity and Intracellular Trafficking<br> - Cancer Cells<br> <br> The book is of prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.

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