Details

International Textbook of Diabetes Mellitus


International Textbook of Diabetes Mellitus


4. Aufl.

von: R. A. DeFronzo, E. Ferrannini, Paul Zimmet, George Alberti

270,99 €

Verlag: Wiley-Blackwell
Format: EPUB
Veröffentl.: 11.03.2015
ISBN/EAN: 9781118387672
Sprache: englisch
Anzahl Seiten: 1240

DRM-geschütztes eBook, Sie benötigen z.B. Adobe Digital Editions und eine Adobe ID zum Lesen.

Beschreibungen

The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.
Contributors xi Preface xxiii Section I: Epidemiology 1 Classification of diabetes mellitus and other categories of glucose intolerance 3Dianna J. Magliano, Paul Zimmet and Jonathan E. Shaw 2 Epidemiology and risk factors for type 1 diabetes mellitus 17Andrea K. Steck and Marian J. Rewers 3 Epidemiology and geography of type 2 diabetes mellitus 29Qing Qiao, Desmond E.Williams, Giuseppina Imperatore, K.M. Venkat Narayan and Jaakko Tuomilehto Section II: Physiology of pancreatic function4 Development and maintenance of the islet ? cell 55Teresa L. Mastracci, Raghavendra G. Mirmira and Ryan M. Anderson 5 Pancreatic morphology in normal and diabetic states 69Rebecca L. Hull and Steven E. Kahn 6 Insulin gene expression and biosynthesis 82Vincent Poitout, Roland Stein and Christopher J. Rhodes7 ?-Cell biology of insulin secretion 96Susumu Seino, Tadao Shibasaki and Kohtaro Minami8 Normal ?-cell function 108Andrea Natali, Stefano Del Prato and Andrea Mari 9 Neuropeptides and islet hormone secretion 125Bo Ahrén 10 Biosynthesis secretion and action of glucagon 136Pierre J. Lefèbvre 11 Incretin physiology in health and disease 145Juris J. Meier and Michael A. Nauck Section III: Normal physiology of insulin action 12 Mechanisms of insulin signal transduction 163Paul R. Langlais, Lawrence J. Mandarino and W. Timothy Garvey 13 Regulation of glucose metabolism in liver 193Shawn C. Burgess 14 Insulin actions in vivo: glucose metabolism 211Ele Ferrannini and Ralph A. DeFronzo 15 Measuring insulin action in vivo 234Richard N. Bergman and Marilyn Ader 16 Protein metabolism in health and diabetes 250Elena Volpi and Jared M. Dickinson 17 Lipid and lipoprotein metabolism hypolipidemic agents and therapeutic goals 262Gissette Reyes-Soffer and Henry N. Ginsberg 18 Metabolomics: applications in type 2 diabetes mellitus and insulin resistance 275Sean H. Adams and John W. Newman Section IV: NAFLD NASH and non-traditional associations with diabetes 19 Pathogenesis of nonalcoholic fatty liver disease (NAFLD) 283Hannele Yki-Järvinen 20 Treatment of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) 292Fernando Bril, Kwame Ntim, Romina Lomonaco and Kenneth Cusi 21 Type 2 diabetes and cancer 306Emily Jane Gallagher, Ruslan Novosyadlyy and Derek LeRoith 22 Diabetes and sleep apnea 316Abd A. Tahrani Section V: Pathogenesis 23 The insulin resistance syndrome 339Naveed Sattar, Paul Welsh and David Preiss24 ?-Cell mass and function in human type 2 diabetes 354Piero Marchetti and Ele Ferrannini 25 Pathogenesis of type 2 diabetes mellitus 371Ralph A. DeFronzo 26 The genetics of type 2 diabetes 401Emma Ahlqvist and Leif Groop 27 Glucose toxicity 413Hannele Yki-Järvinen and Donald A. McClain 28 Monogenic disorders of the ? cell 426Ali J. Chakera and Andrew T. Hattersley 29 Immunopathogenesis of type 1 diabetes in Western society 442Alberto Pugliese 30 Molecular genetics of type 1 diabetes 454M. Ann Kelly, Simon D. Rees, Anthony H. Barnett and Stephen C. Bain Section VI: Obesity 31 The relationship between obesity and type 2 diabetes—the role of gut factors 469Daniel S. Hsia and William T. Cefalu 32 The role of energy metabolism in the regulation of energy balance 479Charmaine S. Tam and Eric Ravussin 33 Treatment of obesity: lifestyle and pharmacotherapy 489Arne Astrup 34 Treatment of obesity: bariatric surgery 505Karl J. Neff Ele Ferrannini and Carel W. le Roux 35 Animal models of obesity and type 2 diabetes 519David A. York, Mie Jung, Park-York and Timothy Gilbertson 36 The role of the hypothalamus in themaintenance of energy balance and peripheral glucose control 529Luis Varela and Tamas L. Horvath Section VII: Clinical trial evidence in diabetes 37 Prevention of type 1 diabetes 541Jay S. Skyler 38 Prevention of type 2 diabetes 550Thomas Yates and Melanie J. Davies 39 Prevention of diabetic microvascular complications 564Alice P.S. Kong and Juliana C.N. Chan Section VIII: Management of diabetes: diet exercise and drugs 40 Dietary management of diabetes mellitus in Europe and North America 577Jim I. Mann and Alexandra Chisholm 41 Exercise 589Henrik Galbo and Erik A. Richter 42 Sulfonylureas and meglitinides: insights into physiology and translational clinical utility 615Harold E. Lebovitz and Arne Melander 43 Metformin and other biguanides: pharmacology and therapeutic usage 641Susan L. Samson and Alan J. Garber 44 PPAR agonists in the treatment of diabetes 657Sunder Mudaliar and Robert R. Henry45 ?-Glucosidase inhibitors 673Josée Leroux-Stewart, Rémi Rabasa-Lhoret and Jean-Louis Chiasson 46 Combination therapy in type 2 diabetes mellitus 686Muhammad Abdul-Ghani, Ralph A. DeFronzo and Roy Eldor 47 New drugs for the treatment of diabetes mellitus 709Clifford J. Bailey 48 Incretin-based therapies 726Michael A. Nauck and Juris J. Meier 49 Insulin pumps 745Dace L. Trence and Irl B. Hirsch 50 Innovative therapies in diabetes: colesevelam and bromocriptine 758Shamsa Ali and Vivian Fonseca Section IX: Management of diabetes: monitoring and other interventions 51 Implantable pumps and artificial and bio-artificial pancreas system 767William V. Tamborlane and Miladys M. Palau-Collazo 52 Pancreas and islet transplantation 774R. Paul Robertson 53 Hypoglycemia and other complications of insulin therapy 783Stephanie A. Amiel 54 Diabetic ketoacidosis and hyperosmolar state 799Abbas E. Kitabchi, Guillermo E. Umpierrez and Mary Beth Murphy Section X: Management of diabetes: glucose and lipid monitoring specific subgroups 55 Type 2 diabetes in obese adolescents: pathophysiology and treatment 817Grace Kim and Sonia Caprio 56 Diabetes in pregnancy 823Yoel Toledano, Eran Hadar and Moshe Hod 57 Aging and diabetes mellitus 836Hermes Florez, Jorge Ruiz and Medha Munshi 58 Psychological problems and management of patients with diabetes mellitus 846Alan M. Delamater, Ashley Marchante, and Jennifer Hernandez 59 Glycated hemoglobin serum proteins and other markers as tools for monitoring 853Susan M. Gerber, Douglas F. Stickle, Intekhab Ahmed, and Serge A. Jabbour Section XI: Complications of diabetes: general and microvasular 60 Pathogenesis of diabetic microvascular complications 875Josephine M. Forbes and Brooke Harcourt 61 Diabetic retinopathy and other ocular complications 889Gavin S. Tan and Tien YinWong 62 Diabetic nephropathy 911George Jerums, Elif I. Ekinci, Erosha Premaratne, Scott T. Baker, Sianna Panagiotopoulos and Richard J. MacIsaac 63 Pathology of human diabetic neuropathy 926M. Mojaddidi, A.K. Sharma and Rayaz A. Malik 64 Autonomic neuropathy 939Chinmay S. Marathe, Liza Phillips and Michael Horowitz 65 Connective tissue disorders in diabetes 953Arlan L. Rosenbloom 66 The diabetic foot 964Frank L. Bowling and Andrew J.M. Boulton 67 Erectile dysfunction in diabetes mellitus 975Michael H. Cummings and Rajesh Rajendran 68 Periodontal disease and diabetes mellitus 988Wenche S. Borgnakke and Robert J. Genco Section XII: Complications of diabetes: macrovascular 69 Epidemiology of macrovascular disease and hypertension in diabetes mellitus 1007Jaakko Tuomilehto, Daiva Rastenyte, Qing Qiao, Noël C. Barengo and Karl Matz 70 Atherogenesis coronary heart disease and insulin resistance syndrome in diabetes 1031Barak Zafrir and Jorge Plutzky 71 Endothelial function and metabolic syndrome 1046Xinpu Chen and Sridevi Devaraj 72 Hemostatic abnormalities in diabetes mellitus 1051R.A. Ajjan and Peter J. Grant 73 Clinical features and treatment of coronary heart disease in diabetes 1064Eberhard Standl, Michael Erbach, Markolf Hanefeld, Oliver Schnell, Bernd Stratmann and Diethelm Tschoepe 74 Arterial hypertension in diabetes: etiology and treatment 1079Colleen Flynn and George Bakris 75 Peripheral vascular and cerebrovascular disease in diabetes mellitus 1091Debabrata Mukherjee Section XIII: Diabetes and public health 76 The diabetes challenge: from human and social rights to the empowerment of people with diabetes 1105C.T. Di Iorio, Fabrizio Carinci and M. Massi Benedetti 77 The economics of diabetes care: a global perspective 1113Rhys Williams Index i
Ralph DeFronzo, Professor of Medicine and Chief of the Diabetes Division, The University of Texas Health Science Centre at San Antonio, and Deputy Director of Texas Diabetic Institute, San Antonio, Texas, USA. Ele Ferrannini, Professor of Internal Medicine, Department of Clinical and Experimental Medicine, University of Pisa School of Medicine, Pisa, Italy. K. George M. M Alberti, Visiting Professor, King's College, London, UK; Senior Research Investigator, Imperial College, London, UK; Emeritus Professor of Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne. Paul Zimmet, Director Emeritus, Victor Smorgon Diabetes Centre, Baker IDI Heart and Diabetes Institute; Adjunct Professor, Monash University; Honorary President, International Diabetes Federation; Chair, Programme Committee, World Diabetes Congress 2013, Melbourne, VIC, Australia.
The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.

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