InflammationFrom Molecular and Cellular Mechanisms to the Clinic
The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.
Inflammation Through the Ages: A Historical Perspective PART I: INDUCERS AND SENSORS OF INFLAMMATION Pathogen-Associated Molecular Patterns Damage-Associated Molecular Patterns Bacterial Toxins Venoms Hypoxia as an Inducer of Inflammation Vaccine Adjuvants Pattern Recognition Receptors PART II: INFLAMMATORY CELLS Monocytes and Macrophages Neutrophils Mast Cells: Master Drivers of Immune Responses against Pathogens Dendritic Cells in Inflammatory Disease Roles for NK Cells and ILC1 in Inflammation and Infection Group 2 and Group 3 Innate Lymphoid Cells: New Actors in Immunity and Inflammation Th9 Cells: From the Bench to the Bedside and Back Again Th17 Cells Platelets Epithelial Cells Inflammation: The Role of Endothelial Cells PART III: INFLAMMATORY MEDIATORS TNF Superfamily Interleukin-17 A-E IL-6 Superfamily Type I and II Cytokine Superfamilies in Inflammatory Responses Chemokines and Chemotaxis Lipid Mediators in Inflammation Free Radicals in Inflammation Proteases Psychiatric Disorders and Inflammation Complement System Heat Shock Proteins PART IV: INFLAMMATION AND HOST RESPONSE Inflammation and Coagulation Mediators and Mechanisms Pain Inflammation, Hormones and Metabolism Microenvironmental Regulation of Innate Immune Cell Function Epigenetics of Inflammation PART V: INFLAMMATION AND DISEASES Allergy and Inflammation Sepsis Autoimmunity and Inflammation Psoriasis and other Skin Inflammatory Diseases Rheumatoid arthritis and other inflammatory articular diseases Missing Heritability of Crohn's Disease and Implications for Therapeutic Targeting and Improved Care Inflammation and Transplantation Inflammatory Mechanisms in Chronic Obstructive Pulmonary Disease Inflammation - from Molecular and Cellular Mechanisms to the Clinic Inflammation and Type 2 Diabetes Inflammation-Mediated Neurodegeneration: Models, Mechanisms, and Therapeutic Interventions for Neurodegenerative Diseases Inflammation in Atherosclerosis Acute Kidney Injury Ischemia-Reperfusion Syndrome Single Nucleotide Polymorphisms and Inflammation PART VI: RESOLUTION OF INFLAMMATION AND TISSUE REPAIR Pentraxins in the Orchestration of Defence and Tissue Repair During the Acute Phase Response Anti-Inflammatory Cytokines, Soluble Receptors and Natural Antagonists Regulatory T Cells Leukocyte Reprogramming Roles of Specialized Pro-Resolving Lipid Mediators in Inflammation-Resolution and Tissue Repair Glucocorticoids The neuroimmune communicatome in inflammation The Inflammatory Response in Tissue Repair PART VII: DETECTION AND TREATMENTS Biomarkers in Inflammation In Vivo Imaging of Inflammation Novel Targets for Drug Development Inflammation, Microbiota and Gut Reconditioning Natural Products as Source of Anti-Inflammatory Drugs
Jean-Marc Cavaillon is professor and Head of the Unit "Cytokines and Inflammation" at Institut Pasteur (Paris). He has been President of the "International Endotoxin and Innate Immunity Society". He is member of the Editorial Boards of few journals including Shock, Journal of Infectious Diseases, and International Journal of Inflammation, and has been Associate-Editor of "Cytokine" (2002-2009). Jean-Marc Cavaillon has an extensive expertise in innate immunity, particularly on cytokines, inflammation, bacterial endotoxins and other Toll-like receptors agonists, endotoxin tolerance, activation of monocytes/macrophages and neutrophils, altered immune status in sepsis and SIRS patients. He is the co-author of a book "Sepsis and non-infectious inflammation: from biology to critical care" (Wiley VCH, 2009) and the author of a book in French on cytokines (Masson, 1993 & 1996) . Jean-Marc Cavaillon has published 145 scientific articles, 77 reviews and 45 chapters in books. Mervyn Singer is Professor of Intensive Care Medicine at University College London. His primary research interests are sepsis and multi-organ failure, infection, shock and haemodynamic monitoring. Funding for these activities primarily comes from the Wellcome Trust, Medical Research Council and National Institute for Health Research. He developed an oesophageal Doppler haemodynamic monitor that is now in widespread use worldwide, the use of which has been shown in multiple studies to improve outcomes after major surgery and reduce length of stay. He has led on a number of important multi-centre trials in critical care. He has authored various papers and textbooks including the Oxford Handbook of Critical Care, now in its 3rd Edition, and is a Council member of the International Sepsis Forum. He was the first UK intensivist to be awarded Senior Investigator status by the National Institute for Health Research, and to be invited to give plenary lectures at the European and US Intensive Care Congresses.
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