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<p>List of Contributors ix</p> <p>1 Introduction and Classification of Infections of the CNS According to the Agent 1<br /><i>Fabrice Chrétien, Kum Thong Wong, Leroy R. Sharer, Catherine (Katy) Keohane, and Françoise Gray</i></p> <p>2 Sepsis‐Associated Encephalopathy 11<br /><i>Franck Verdonk, Aurelien Mazeraud, Fabrice Chrétien, and Tarek Sharshar</i></p> <p>3 Variation of CNS Infections According to the Host 21<br /><i>Leroy R. Sharer, Catherine (Katy) Keohane, and Françoise Gray</i></p> <p>4 Clinical Approach to the Adult Patient with CNS Infection 29<br /><i>Michel Wolff, Romain Sonneville, and Tarek Sharshar</i></p> <p>5 Herpes Simplex Virus Infections of the CNS 43<br /><i>Bette K. Kleinschmidt‐DeMasters, Catherine (Katy) Keohane, and Françoise Gray</i></p> <p>6 Varicella‐Zoster Virus and Epstein‐Barr Virus Infections of the CNS 55<br /><i>Catherine (Katy) Keohane and Françoise Gray</i></p> <p>7 Cytomegalovirus Infections of the CNS 65<br /><i>Homa Adle‐Biassette and Natacha Teissier</i></p> <p>8 Adenovirus Meningoencephalitis 77<br /><i>Harry V. Vinters and Xinhai R. Zhang</i></p> <p>9 Polyomavirus Infections of the CNS 83<br /><i>Susan Morgello</i></p> <p>10 Measles Virus Infection of the CNS 95<br /><i>Catherine (Katy) Keohane, Leroy R. Sharer, and Françoise Gray</i></p> <p>11 Rubella Virus 105<br /><i>Bette K. Kleinschmidt‐DeMasters</i></p> <p>12 Henipavirus Encephalitis 113<br /><i>Kum Thong Wong and Kien Chai Ong</i></p> <p>13 Rabies 121<br /><i>Guilherme Dias de Melo, Perrine Parize, Grégory Jouvion, Laurent Dacheux, Fabrice Chrétien, and Hervé Bourhy</i></p> <p>14 Flaviviruses 1: General Introduction and Tick‐Borne Encephalitis 131<br /><i>Herbert Budka</i></p> <p>15 Flaviviruses 2: West Nile, St. Louis Encephalitis, Murray Valley Encephalitis, Yellow Fever, and Dengue 147<br /><i>Edward S. Johnson and Juan M. Bilbao</i></p> <p>16 Flaviviruses 3: Zika Virus Infection of the CNS 163<br /><i>Leila Chimelli</i></p> <p>17 Flaviviruses 4: Japanese Encephalitis 169<br /><i>Shankar Krishna Susarla, Anita Mahadevan, Bishan Radotra, Masaki Takao, and Kum Thong Wong</i></p> <p>18 CNS Disorders Caused by Hepatitis C and Hepatitis E Viruses 177<br /><i>Melissa Umphlett, Clare Bryce, and Susan Morgello</i></p> <p>19 Alphaviral Equine Encephalomyelitis (Eastern, Western, and Venezuelan) 183<br /><i>Kum Thong Wong</i></p> <p>20 Chikungunya Virus 189<br /><i>Cássia Shinotsuka, Michael Blatzer, Grégory Jouvion, and Fabrice Chrétien</i></p> <p>21 Poliovirus Infection and Postpolio Syndrome 195<br /><i>Catherine (Katy) Keohane, Leila Chimelli, and Aisling Ryan</i></p> <p>22 Enterovirus A71 Infection 205<br /><i>Kum Thong Wong, Kien Chai Ong, Thérèse Couderc, and Marc Lecuit</i></p> <p>23 Human Immunodeficiency Virus Infection of the CNS 215<br /><i>Françoise Gray and Leroy R. Sharer</i></p> <p>24 HTLV‐1 and Neurological‐Associated Disease 231<br /><i>Antoine Gessain, Olivier Cassar, and Philippe V. Afonso</i></p> <p>25 Parechovirus A 243<br /><i>Clayton A. Wiley</i></p> <p>26 Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Leukoencephalomyelitis 251<br /><i>Romana Höftberger and Hans Lassmann</i></p> <p>27 Miscellaneous Inflammatory Disorders of the CNS of Possible Infectious Origin 259<br /><i>Mari Perez‐Rosendahl, Jamie Nakagiri, Xinhai R. Zhang, and Harry V. Vinters</i></p> <p>28 Mycoplasmal and Rickettsial Infections of the CNS 267<br /><i>Roy H. Rhodes</i></p> <p>29 Pathogenesis and Pathophysiology of Bacterial Infections of the CNS 279<br /><i>Loic Le Guennec and Sandrine Bourdoulous</i></p> <p>30 Pyogenic Infections of the CNS 1: Acute Bacterial Meningitis 295<br /><i>Loic Le Guennec and Sandrine Bourdoulous</i></p> <p>31 Pyogenic Infections of the CNS 2: (Brain Abscess, Subdural Abscess or Empyema, Epidural Abscess, Septic Embolism, and Suppurative Intracranial Phlebitis) 309<br /><i>Arnault Tauziede‐Espariat, Alexandre Roux, Megan Still, Marc Zanello, Gilles Zah‐Bi, Ghazi Hmeydia, Catherine Oppenheim, Michel Wolff, Johan Pallud, and Fabrice Chrétien</i></p> <p>32 Pyogenic Infections of the CNS 3: Following Neurosurgical Procedures 319<br /><i>Alexandre Roux, Megan Still, Marc Zanello, Gilles Zah‐Bi, Arnault Tauziede‐Espariat, Ghazi Hmeydia, Catherine Oppenheim, Michel Wolff, Fabrice Chrétien, and Johan Pallud</i></p> <p>33 CNS Involvement in Tropheryma whipplei Infection 331<br /><i>Emmanuèle Lechapt‐Zalcman</i></p> <p>34 Cerebral Actinomycosis 337<br /><i>Arnault Tauziede‐Espariat</i></p> <p>35 Cerebral Nocardiosis 343<br /><i>Arnault Tauziede‐Espariat and Leroy R. Sharer</i></p> <p>36 CNS Tuberculosis 349<br /><i>Michael A. Farrell, Eoin R. Feeney, and Jane B. Cryan</i></p> <p>37 Non‐Tuberculous Mycobacterial Infections 357<br /><i>Leroy R. Sharer</i></p> <p>38 Spirochetal Infections of the CNS 363<br /><i>Françoise Gray and Catherine (Katy) Keohane</i></p> <p>39 Neurobrucellosis 379<br /><i>Marine Le Dudal, Fabrice Chrétien, and Grégory Jouvion</i></p> <p>40 Legionellosis 383<br /><i>Edward S. Johnson</i></p> <p>41 Neurosarcoidosis 393<br /><i>Michael A. Farrell and Alan Beausang</i></p> <p>42 Hypertrophic Pachymeningitis 403<br /><i>Françoise Gray and Leroy R. Sharer</i></p> <p>43 Toxin‐Induced Neurological Diseases 411<br /><i>Pierre L. Goossens, Cédric Thépenier, and Michel R. Popoff</i></p> <p>44 Fungal Infections of the CNS 419<br /><i>Michael Blatzer, Fanny Lanternier, Jean‐Paul Latgé, Anne Beauvais, Stéphane Bretagne, Fabrice Chrétien, and Grégory Jouvion</i></p> <p>45 Cerebral Malaria 437<br /><i>Patrícia Reis, Vanessa Estato, and Hugo Caire de Castro Faria Neto</i></p> <p>46 Toxoplasma Infection of the CNS 449<br /><i>Stéphane Bretagne, Catherine (Katy) Keohane, and Homa Adle‐Biassette</i></p> <p>47 Other Protozoal Infections 463<br /><i>Leila Chimelli and Catherine (Katy) Keohane</i></p> <p>48 Helminth Infections of the CNS 475<br /><i>Marine Le Dudal, Stéphane Bretagne, David Hardy, Fabrice Chrétien, and Grégory Jouvion</i></p> <p>Appendix: CASE EXAMPLE: Schistosoma mekongi Neuroschistosomiasis 500<br /><i>Edward S. Johnson</i></p> <p>49 Brain Myiasis 503<br /><i>Arnault Tauziede‐Espariat</i></p> <p>50 Emerging CNS Infections 505<br /><i>Kum Thong Wong</i></p> <p>Index 515</p>

<p><b>EDITORS:</b> <p><b>FABRICE CHRÉTIEN, MD, PhD</b> is Head of Neuropathology at the Sainte Anne Hospital, Paris; Professor of Neuropathology at the Paris University, Paris; and Unit Director at the Experimental Neuropathology Unit, Pasteur Institute, Paris, France. <p><b>KUM THONG WONG, MBBS, MPath, FRCPath, MD</b> is Professor of Pathology, Faculty of Medicine at the University of Malaya, Kuala Lumpur, Malaysia. <p><b>LEROY R. SHARER, MD</b> is Professor of Anatomic Pathology and Neuropathology, Department of Pathology, Immunology, and Laboratory Medicine at the Rutgers New Jersey Medical School and University Hospital, Newark, NJ, USA. <p><b>SERIES EDITORS:</b> <p><b>CATHERINE (KATY) KEOHANE, MB, BCh, BAO, FRCPath, FFPath</b> is a Neuropathologist and Professor at the School of Medicine, University College Cork, Brookfield Health Science Complex, Cork, Ireland. <p><b>FRANÇOISE GRAY, MD, PhD</b> is Professor of Pathology (retired) at the Lariboisière Hospital, APHP, Paris; and University Paris Diderot (Paris 7), Paris, France.

<p><b>Comprehensive clinical reference on infections of the central nervous system</b> <p><i>Infections of the Central Nervous System – Pathology and Genetics</i> is a complete clinical reference on CNS infections from the International Society of Neuropathology and the Pasteur Institute, Paris. This book contains an inclusive contents list of both common and rare disorders affecting the central nervous system. A team of internationally-recognized experts provide clinical, pathological and genetic information on a wide range of viral, bacterial, fungal, parasitic, and other infectious diseases. <p>Templated, easily-referenced chapters provide definitions, microbiological characteristics specific to the agent, information on genetics and pathogenesis, animal models, and treatment of each CNS infection. Clinical features presented include appropriate investigations—biochemistry, electrophysiology, CSF analysis, specific laboratory tests, and imaging—and important differential diagnosis. Detailed entries include incidence and prevalence, geographical distribution, risk factors, and other epidemiological data. The pathology of each infection includes histopathology, electron microscopy, and immunocytochemistry. This authoritative volume: <ul> <li>Offers 50 chapters covering a wide range of CNS infections</li> <li>Provides definitions of each disorder, major synonyms, and historical perspective</li> <li>Includes general chapters on the classification and pathophysiology of CNS infections</li> <li>Contains over 190 illustrations and tables, online resources, and nearly 1000 references</li> <li>Presents clinical approaches to patients with CNS infections</li> </ul> <p><i>Infections of the Central Nervous System, Neuropathology and Genetics</i> is an essential reference for neurologists, pathologists, neuropathologists, infectious disease specialists, and general physicians in internal medicine.

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