Details

<p>Preface, ix</p> <p>Contributors, xi</p> <p>Index of Lessons in Normal Immunity, xiii</p> <p>INTRODUCTION TO CASE STUDIES: A GUIDE TO USING THIS BOOK, 1</p> <p><b>Unit I IMMUNODEFICIENCY DISEASES, 3</b></p> <p>INTRODUCTION: ORGANIZATION OF THE IMMUNE SYSTEM AND EVALUATION OF THE IMMUNODEFICIENT PATIENT, 5</p> <p>1 X-LINKED AGAMMAGLOBULINEMIA (BRUTON’S AGAMMAGLOBULINEMIA), 15</p> <p>2 SEVERE COMBINED IMMUNODEFICIENCY DISEASE, 27</p> <p>3 DiGEORGE SYNDROME (CONGENITAL THYMIC APLASIA), 41</p> <p>4 HYPER-IgM SYNDROME, 53</p> <p>5 COMMON VARIABLE IMMUNODEFICIENCY DISEASE, 67</p> <p>6 AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME (ALPS), 81</p> <p>7 X-LINKED LYMPHOPROLIFERATIVE SYNDROME, 91</p> <p>8 HEREDITARY ANGIOEDEMA, 101</p> <p>9 ACQUIRED IMMUNODEFICIENCY SYNDROME, 111</p> <p><b>Unit II IMMEDIATE HYPERSENSITIVITY AND MAST CELL DISORDERS, 125</b></p> <p>INTRODUCTION: WHEN ANTIGENS BECOME ALLERGENS, 127</p> <p>10 MASTOCYTOSIS, 129</p> <p>11 ANAPHYLAXIS, 137</p> <p>12 ASTHMA, 147</p> <p>13 THE VASCULITIDES, 161</p> <p><b>Unit III AUTOIMMUNE DISORDERS, 173</b></p> <p>INTRODUCTION: OVERVIEW OF AUTOIMMUNE DISORDERS AND MECHANISMS OF TOLERANCE, 175</p> <p>14 MYASTHENIA GRAVIS, 183</p> <p>15 MULTIPLE SCLEROSIS, 195</p> <p>16 DIABETES MELLITUS TYPE 1, 207</p> <p>17 CELIAC DISEASE, 219</p> <p>18 INFLAMMATORY BOWEL DISEASE, 231</p> <p>19 PSORIASIS, 245</p> <p>20 IgA NEPHROPATHY AND KIDNEY TRANSPLANTATION, 255</p> <p>21 RHEUMATOID ARTHRITIS, 269</p> <p>22 SYSTEMIC LUPUS ERYTHEMATOSUS, 283</p> <p>23 SCLERODERMA, 299</p> <p><b>Unit IV MALIGNANCIES OF THE LYMPHOID SYSTEM, 309</b></p> <p>INTRODUCTION: CLASSIFICATION OF LYMPHOID MALIGNANCIES, 311</p> <p>24 CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA, 317</p> <p>25 FOLLICULAR LYMPHOMA, 327</p> <p>26 PLASMA CELL NEOPLASMS, 337</p> <p><b>Unit V 349</b></p> <p>LABORATORY TESTS USED IN THE WORKUP OF PATIENTS WITH IMMUNOLOGIC DISEASES, 351</p> <p>Index, 369</p>

<p>"In all, while written as a clinically-relevant companion for an immunology text, this book can stand alone as a wonderful resource for any clinical immunologist and can serve as an excellent teaching aid for anyone studying immunology or training in a field that cares for patients with immune disorders." (<i>The World Allergy Organization</i>, 1 August 2011)</p> <p>"[This book] effectively accomplishes its stated goals. This well-written and easy-to-read book covers a wide variety of topics... and provides a wealth of experience in a patient-oriented format. The editors of this book succeed in moving readers from beginning to end using this case-based approach. [This book] offers a number of teaching possibilities and could be useful in teaching immunology when combined with current textbooks." (<i>JAMA</i>, April 2010)</p>

<b>Warren Strober</b>, M.D., is Section Chief in the Laboratory of Clinical Investigation, Mucosal Immunity Section at the National Institute of Allergy and Infectious Diseases, National Institutes of Health. <p><b>Susan R.S. Gottesman</b>, M.D., Ph.D., is Associate Professor in the Department of Pathology at SUNY Health Science Center at Brooklyn.</p>

<p><b>The most up-to-date collection of immunology cases from world-class authorities in each disease entity</b></p> <p>This book offers a comprehensive, cutting-edge selection of real-life case studies for in-depth investigation into the impact of immunology on modern medical diagnosis and treatment. Twenty-six case studieseffectively cover: immunodeficiency diseases, immediate hyper-sensitivity and mast cell disorders, autoimmune disorders, and malignancies of the lymphoid system. Each chapter presents a case study with a detailed background of the relevant immunological disorder, real data, references, and a conclusion, with interwoven discussion questions throughout. Each case study puts the individual patient into a larger context of the disease as it is seen in the patient population as a whole. Full-color photographs and illustrations complement the case studies, while a uniform presentation of the material across the book enhances readability.</p> <p>This book offers medical students and professionals the complete tools necessary to understand and evaluate common clinical scenarios, and to teach these clinical conditions to others. It may be used alone or as a companion to the widely acclaimed <i>Immunology: A Short Course</i>, Sixth Edition (Wiley).</p>

US