Details

Introduction (Mitchison). <p>Mechanisms of peripheral T cell tolerance (L. Parijs, <i>et al.</i>).</p> <p>B cell antigen receptor signalling in the balance of tolerance and immunity (Cirnall and FGoodnow).</p> <p>General discussion I.</p> <p>The study of self-tolerance using murine haemoglobin as a model self antigen (Williams and Allen).</p> <p>Tolerance and determinant hierarchy (Schnieder et al).</p> <p>Molecular genetic studies in lymphocyte apoptosis and human autoimmunity (Martin, <i>et al.</i>).</p> <p>General discussion II.</p> <p>A Role for CTLA-4-mediated inhibitory signals in peripheral T Cell tolerance? (Allison, et al).</p> <p>Antigen-specific CD4⁺ Tcells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defect (pape et al).</p> <p>Antigen-specific tolerance induction and the immunotherapy of experimental autoimmunity disease (Anderton, et al.).</p> <p>Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes (Healy, et al.).</p> <p>Tolerance induction with CD4 monoclonal antibodies (Waldmann et al).</p> <p>Cross-presentation of self antigens to CD8⁺ Tcells: the balance between tolerance and autoimmunity (Kurts et al).</p> <p>General discussion III.</p> <p>Tolerance induction in mature T lymphocytes (Alferink, et al.).</p> <p>T lymphocyte-mediated control of autoimmunity (E. Shevach, et al.).</p> <p>Final General Discussion.</p> <p>Indexes. </p>

The <strong>Novartis Foundation</strong> is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

The issue of self/non-self discrimination amongst lymphocytes is of vital importance in our understanding of the basic processes of immune recognition. Over the past decades there have been considerable advances in our knowledge of the role of the thymus in "educating" T cells to distinguish self from non-self, and recently there has been a greater appreciation of the importance of immunological tolerance in the periphery during the development of immune responses. Issues as diverse as apoptosis, cell signalling and cell cycle progression, and expression of cytokines have all influenced recent research on the consequences of immunological recognition of foreign antigens. It is clear that the immune system has developed an intricate process for regulating its responses to non-self antigens and, more importantly, self antigens in potential autoimmune settings. This book brings together scientists working on all aspects of immunological tolerance. A number of chapters discuss basic mechanisms of tolerance, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Several chapters deal specifically with costimulation and tolerance. Finally, careful consideration is given to the clinical applications of our understanding of immunological tolerance. Topics discussed include T cell activation during tumour therapy, anti-antigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy and tolerance during various autoimmune diseases.

GB