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<p><i>Contributors, vii</i></p> <p><i>Preface, x</i></p> <p><i>Acknowledgments, xi</i></p> <p>1 Theories of Blood Coagulation: Basic Concepts and Recent Updates, 1<br /> <i>Dougald M. Monroe and Maureane Hoffman</i></p> <p>2 Vascular Endothelium, Infl uence on Hemostasis: Past and Present, 14<br /> <i>Hussain I. Saba and Sabiha R. Saba</i></p> <p>3 Coagulation Testing: Basic and Advanced Clinical Laboratory Tests, 30<br /> <i>Nils Egberg and Margareta Blombäck</i></p> <p>4 Factor VIII Defi ciency or Hemophilia A: Clinical Bleeding and Management, 45<br /> <i>Pier Mannuccio Mannucci and Massimo Franchini</i></p> <p>5 Factor IX Defi ciency or Hemophilia B: Clinical Manifestations and Management, 57<br /> <i>Raj S. Kasthuri, Harold R. Roberts, and Paul E. Monahan</i></p> <p>6 Factor XI Deficiency or Hemophilia C, 71<br /> <i>Charles E. Bane, Anne T. Neff, and David Gailani</i></p> <p>7 Factor VIII and IX Inhibitors in Hemophilia, 82<br /> <i>Meera Chitlur and Jeanne Lusher</i></p> <p>8 Treatment Options for Acquired Hemophilia, 93<br /> <i>Anjali Sharathkumar and David Green</i></p> <p>9 Factor XII Deficiency or Hageman Factor Deficiency, 112<br /> <i>Evi X. Stavrou and Alvin H. Schmaier</i></p> <p>10 Inherited Combined Factor Deficiency States, 127<br /> <i>Asma Latif and Louis Aledort</i></p> <p>11 Acute and Chronic Immune Thrombocytopenia: Biology, Diagnosis, and Management, 137<br /> <i>Samir Dalia and Benjamin Djulbegovic</i></p> <p>12 Disseminated Intravascular Coagulation: Diagnosis and Management, 151<br /> <i>Stephanie J. Davis and Craig M. Kessler</i></p> <p>13 Mechanisms of Fibrinolysis and Basic Principles of Management, 169<br /> <i>John W. Weisel and Rustem I. Litvinov</i></p> <p>14 Post-thrombotic Syndrome, 186<br /> <i>Jean-Philippe Galanaud and Susan R. Kahn</i></p> <p>15 Von Willebrand Disease: Clinical Aspects and Practical Management, 197<br /> <i>Francesco Rodeghiero, Alberto Tosetto, and Giancarlo Castaman</i></p> <p>16 Platelets in Hemostasis: Inherited and Acquired Qualitative Disorders, 209<br /> <i>Noman Ashraf and Hussain I. Saba</i></p> <p>17 Contributions of Platelet Polyphosphate to Hemostasis and Thrombosis, 236<br /> <i>James H. Morrissey</i></p> <p>18 Thrombotic Microangiopathy: Biology, Diagnosis, and Management, 246<br /> <i>Samir Dalia and Hussain I. Saba</i></p> <p>19 Hemostasis and Aging, 259<br /> <i>Lodovico Balducci</i></p> <p>20 Hemostatic Problems in Chronic and Acute Liver Disease, 271<br /> <i>Ton Lisman and Robert J. Porte</i></p> <p>21 Cancer and Thrombosis, 284<br /> <i>Erica A. Peterson and Agnes Y. Y. Lee</i></p> <p>22 An Update on Low-Molecular-Weight Heparins, 296<br /> <i>Jawed Fareed, Debra Hoppensteadt, and Walter P. Jeske</i></p> <p><i>Index, 315</i></p> <p><i>Color plate section can be found facing page 212</i></p>

<p>“This new handbook will cover all aspects of the practical mangement of commonly encountered thrombotic and bleeding disorders, with emphasis on clinical diagnosis, treatment and day-to-day management. It will distil the most clinically relevant material from the literature for all those working in the field of haemostasis and thrombosis.”  (<i>Kingbook73's Medical Ebook and Video Collection</i>, 20 September 2014)</p> <p> </p>

<p><strong>Dr Hussain Saba</strong>, James A. Haley Veterans Hospital, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida, USA. <p><strong>Dr Harold Roberts</strong>, School of Medicine, Division of Hematology Oncology, Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA.

<p><b>Hemostasis and Thrombosis: Practical Guidelines in Clinical Management</b></p> <p>Edited by</p> <p><b>Hussain I Saba MD, PhD</b></p> <p>Professor of Medicine</p> <p>Director of Hematology/Hemophilia/Hemostasis & Thrombosis Center</p> <p>USF College of Medicine</p> <p>Professor Emeritus</p> <p>Department of Malignant Hematology</p> <p>Moffitt Cancer Center and Research Institute</p> <p>Tampa, FL, USA</p> <p> </p> <p><b>Harold R Roberts MD</b></p> <p>Emeritus Professor of Medicine and Pathology</p> <p>Division of Hematology / Oncology</p> <p>University of North Carolina</p> <p>Chapel Hill, NC, USA</p> <p><br /> Hemostasis and thrombosis is a hugely important, changing and complex area that impacts many other medical specialties, affecting at least 10 million people in the United States alone. It is vital for physicians to recognize abnormalities of hemostasis and thrombosis and to be able to address these problems in their patients.</p> <p><b>Hemostasis and Thrombosis: Practical Guidelines in Clinical Management</b>covers all aspects of the practical<br /> management of commonly encountered thrombotic and bleeding disorders, with emphasis on clinical diagnosis, treatment, and day-to-day management. The most clinically relevant material from the literature has been carefully compiled, along with:<br /> <br />  - Discussions of new and upcoming diagnostic and therapeutic modalities</p> <p>- Practical clinical advice for all those dealing with coagulation, hemostasis and thrombosis<br /> <br /> Written by world leading specialists contributing their expertise in succinct text and focusing on the latest clinical guidance, <b>Hemostasis and Thrombosis: Practical Guidelines in Clinical Management</b> will benefit hematologists in training and in practice working in the fields of coagulation, hemostasis and thrombosis.</p> <p><b><br /> Titles of related interest</b></p> <p><b><i>Practical Hemostasis and Thrombosis, 2nd Edition</i></b></p> <p><a href="http://www.wiley.com/WileyCDA/Section/id-302475.html?query=Nigel+Key">Key</a>, ISBN 9781405184601</p> <br /> <p><b><i>Hemophilia and Hemostasis: A Case-Based Approach to Management, 2nd Edition</i></b></p> <p>Ma, ISBN 9780470659762</p> <br /> <p><b><i>Quality in Laboratory Hemostasis and Thrombosis, 2nd Edition</i></b></p> <p><a href="http://www.wiley.com/WileyCDA/Section/id-302475.html?query=Steve+Kitchen">Kitchen</a>, ISBN 9780470671191</p> <br /> <br /> <p><b> </b><a href="http://www.wiley.com/go/hematology"><b>www.wiley.com/go/hematology</b></a></p>

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