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Preface. <p>About the Author.</p> <p>Acknowledgements.</p> <p><b>Introduction.</b></p> <p><b>1. General introduction.</b></p> <p>1.1 Revision of molecular genetics.</p> <p>1.2 The tools of molecular biology.</p> <p>1.3 Specifics of the genome programmes.</p> <p>1.4 The species analysed.</p> <p><b>2. Linkage maps.</b></p> <p>2.1. Tools and methods in genetic mapping.</p> <p>2.2 The development of genetic maps.</p> <p>2.3 Radiation hybrid maps.</p> <p>2.4 Conclusion.</p> <p><b>3. Physical maps.</b></p> <p>3.1 Local maps or small genomes.</p> <p>3.2 Strategies for physical mapping of the human genome.</p> <p>3.3 Maps of the human genome.</p> <p>3.4 Conclusion.</p> <p><b>4. Genome sequencing</b> .</p> <p>4.1 Strategic choices.</p> <p>4.2 Prokaryotic genomes.</p> <p>4.3 Genomes of model eukaryotes.</p> <p>4.4 The human genome. & lt;div></p> <p>4.5 Conclusion.</p> <p><b>5. Sequencing cDNA and the transcriptome.</b></p> <p>5.1 Strategies of cDNA sequencing.</p> <p>5.2 The economic stakes.</p> <p>5.3 The analysis of cDNA sequences.</p> <p>5.4 The transcriptome.</p> <p>5.5 Conclusion.</p> <p><b>6. The proteome.</b></p> <p>6.1 Basic techniques.</p> <p>6.2 Transgenesis .</p> <p>6.3 Mutagenesis.</p> <p>6.4 Two-dimensional electrophoresis and identification of proteins.</p> <p>6.5 Identification of protein interactions by twin hybrids.</p> <p>6.6 Chip technology.</p> <p>6.7 Analysis of three-dimensional structure.</p> <p>6.8 Conclusions.</p> <p><b>7. Identification of genes responsible for disease.</b></p> <p>7.1 Genetic diseases.</p> <p>7.2 Functional cloning and chromosomal anomalies.</p> <p>7.3 Strategy for positional cloning.</p> <p>7.4 What is the future for the cloning of disease-causing genes?</p> <p>7.5 Conclusion.</p> <p><b>General Conclusion.</b></p> <p><b>Further Readiing.</b></p> <p><b>Index.</b></p>

"The book provides a brilliant introduction into topics that….become increasingly difficult to summarize…will immensely benefit students…" (<i>Annals of Biomedical Engineering</i>, July 2006) <p>"…a good textbook and should be very useful in school, college, and university libraries." (<i>E-STREAMS</i>, September 2005)</p> <p>"…a well written introduction to modern genetic analysis." (<i>CHOICE</i>, June 2005)</p> <p>"It will immensely benefit students" (<i>Annals of Biomedical Engineering, July 2006)</i></p>

Alain Bernot is a graduate of the École normale supérieure, PHD, and Professor at the Université d'Evry. He is currently working in a genetic therapy programme at Genethon. He previously directed the sequencing and analysis of a vertebrate genome (Tetraodon nigroviridis), and contributed to the identification of a gene responsible for a human genetic disease (Mediterranean familial fever).

<b>Genome Transcriptome and Proteome Analysis</b> is a concise introduction to the subject, successfully bringing together these three key areas of research. Starrting with a revision of molecular genetics the book offers clear explanations of the tools and techniques widely used in genome, transcriptome and proteome analysis. Subsequent chapters offer a broad overview of linkage maps, physical maps and genome sequencing, with a final discussion on the identification of genes responsible for disease. <p>An invaluable introduction to the basic concepts of the subject, this text offers the student an excellent overview of current research methods and applications and is a good starting point for those new to the area.</p> <ul> <li>A clear, concise introduction to the subject of modern genomic analysis.</li> <li>A technology-oriented approach including the latest developments in the field.</li> <li>Invaluable to those students taking courses in Bioinformatics, Human Genetics, Biochemistry and Molecular Biology.</li> </ul>

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