Details

<p>Contributors xi</p> <p>Editorial Preface xvii</p> <p>Abbreviations xix</p> <p><b>PART I FLUORINE-18 LABELED RADIOPHARMACEUTICALS 1</b></p> <p>1. Synthesis of (−)-[18F]Flubatine ([18F]FLBT) 3<br /><i>Megan N. Stewart, Brian G. Hockley, and Peter J. H. Scott</i></p> <p>2. Synthesis of [18F]-(−)Fluoroethoxy Benzovesamicol ([18F]FEOBV) 13<br /><i>Brian G. Hockley, Megan N. Stewart, and Peter J. H. Scott</i></p> <p>3. Synthesis of [18F]Fluoromethylcholine ([18F]FCH) via [18F]Fluoromethyl Tosylate 21<br /><i>Melissa E. Rodnick, Allen F. Brooks, Brian G. Hockley, Bradford D. Henderson, and Peter J. H. Scott</i></p> <p>4. Radiosynthesis of [18F]Flotegatide ([18F]RGD-K5) 29<br /><i>Hartmuth C. Kolb, Fanrong Mu, Umesh Gangadharmath, Vani P. Mocharla, Zhihong Zhu, Ashok Chaudhary, and Joseph C. Walsh</i></p> <p>5. Synthesis of 3-[18F]Fluoro-5-(2-Pyridinylethynyl) Benzonitrile ([18F]FPEB) 41<br /><i>Steven H. Liang, Daniel L. Yokell, Raul N. Jackson, Peter A. Rice, Eli Livni, David Alagille, Gilles Tamagnan, Thomas Lee Collier, and Neil Vasdev</i></p> <p>6. Radiosynthesis of 2′-Deoxy-2′-[18F]Fluoro-5-Methyl-1-β-d-Arabinofuranosyluracil ([18F]FMAU) 53<br /><i>Kai Chen and Peter S. Conti</i></p> <p><b>PART II CARBON-11 LABELED RADIOPHARMACEUTICALS 63</b></p> <p>7. Synthesis of N-[11C]Methyl-4-Piperidinyl Propionate ([11C]PMP) 65<br /><i>Xia Shao and Peter J. H. Scott</i></p> <p>8. Synthesis of 1-(2,4-Dichlorophenyl)-4-Cyano-5-(4-[11C]methoxyphenyl)-N-(Piperidin-1-yl)-1H-Pyrazole-3-Carboxamide ([11C]OMAR) 73<br /><i>Xia Shao, Keunsam Jang, and Peter J. H. Scott</i></p> <p>9. Synthesis of Carbon-11 Labeled (+)-4-Propyl-3,4,4a,5,6,10b-Hexahydro-2H-Naphtho[1,2-b][1,4]Oxazin-9-Ol ([11C]-(+)-PHNO) 81<br /><i>Christophe Plisson, Joaquim Ramada-Magalhaes, and Jan Passchier</i></p> <p>10. Synthesis of (R)-[N-Methyl-11C]PK11195 93<br /><i>Vítor H. Alves, Antero J. Abrunhosa, and Miguel Castelo-Branco</i></p> <p><b>PART III OTHER RADIOPHARMACEUTICALS 103</b></p> <p>11. Synthesis of Oxygen-15 Water ([15O]H2O) 105<br /><i>David W. Dick and G. Leonard Watkins</i></p> <p><b>PART IV NEW METHODS FOR THE SYNTHESIS AND QUALITY CONTROL OF RADIOPHARMACEUTICALS 115</b></p> <p>12. Direct, Nucleophilic Radiosynthesis of [18F]Trifluoroethyl Tosylate 117<br /><i>Patrick J. Riss, Waqas Rafique, and Franklin I. Aigbirhio</i></p> <p>13. Synthesis of [18F]N-Methyl Lansoprazole via Generation of a [18F]Trifluoromethyl Group 123<br /><i>Allen F. Brooks, Melissa E. Rodnick, Garret M. Carpenter, and Peter J. H. Scott</i></p> <p>14. [18F]Fluorination of (Mesityl)(Aryl)Iodonium Salts 129<br /><i>Naoko Ichiishi, Allen F. Brooks, Joseph J. Topczewski, Melissa E. Rodnick, Melanie S. Sanford, and Peter J. H. Scott</i></p> <p>15. Pd(IV)-Mediated Fluorination of Arenes with [18F]F– for PET Imaging 139<br /><i>Nathan J. Schauer, Stephen M. Carlin, Hong Ren, and Jacob M. Hooker</i></p> <p>16. Silicon Fluoride Acceptors (SIFAs) for Peptide and Protein Labeling with 18F 149<br /><i>Ralf Schirrmacher, Alexey Kostikov, Carmen Wängler, Klaus Jurkschat, Vadim Bernard-Gauthier, Esther Schirrmacher, and Björn Wängler</i></p> <p>17. Solid Phase Synthesis of [18F]-2-Fluoro-2-Deoxy-d-Glucose: A Resin-Linker-Vector (RLV) Approach 163<br /><i>Lynda J. Brown, Imtiaz Khan, Harry J. Wadsworth, Alexander Jackson, Nianchun Ma, Nicolas Millot, Sue M. Champion, Denis R. Bouvet, Alex M. Gibson, and Richard C. D. Brown</i></p> <p>18. Production and Reaction of [11C]Carbon Disulfide for the Synthesis of [11C]Dithiocarbamates 177<br /><i>Philip W. Miller</i></p> <p>19. One-Pot, Direct Incorporation of [11CO2] into Carbamates 185<br /><i>Christian K. Moseley and Jacob M. Hooker</i></p> <p>20. Radiosynthesis of [11C]Carboxamides via Reaction of [11C]CO2 Captured by a Cu(I)-Based Catalyst System with Boronic Acid Ester Precursors 197<br /><i>Patrick J. Riss, Shuiyu Lu, Sanjay Telu, Franklin I. Aigbirhio, and Victor W. Pike</i></p> <p>21. Ethanol as a Solvent for Carbon-11 Radiochemistry 207<br /><i>Xia Shao, Maria V. Fawaz, Keunsam Jang, and Peter J. H. Scott</i></p> <p>22. Synthesis and Applications of [11C]Hydrogen Cyanide 233<br /><i>Xia Shao, Melissa E. Rodnick, Allen F. Brooks, and Peter J. H. Scott</i></p> <p>23. Determination of Radiochemical Purity and Radiochemical Identity of [13N]NH3 Using Thin Layer Chromatography 241<br /><i>Peter A. Rice and Daniel L. Yokell</i></p> <p>Appendix 1: Supplier Information 247</p> <p>Index 253</p>

<b>Peter J. H. Scott </b>is an Assistant Professor in the Department of Radiology at the University of Michigan Medical School (USA), Director of the University of Michigan PET Center (USA) and a member of the Interdepartmental Program in Medicinal Chemistry. Professor Scott edited <i>Linker Strategies in Solid-Phase Organic Synthesis</i> (also from Wiley) and is the series editor for both the Wiley Series on Radiochemical Syntheses and the Wiley Series on Solid Phase Organic Syntheses.

<p><b>The ultimate reference guide to the synthesis of radiopharmaceutical</b><br /><br />The Radiochemical Syntheses series provides scientists and professionals with a comprehensive reference to proven synthetic methods for radiochemical reactions, along with step-by-step guidance on how to replicate these syntheses in the laboratory.<br /><br />Volume 2 in the series focuses on the synthesis and purification of radiopharmaceuticals in clinical use today as well as important new methods in radiochemistry. Contributions from leading researchers detail methods and procedures for conducting radiochemical reactions to prepare important radiopharmaceuticals that are used in positron emission tomography (PET) imaging. Also highlighted in this book are new approaches to carbon-11 (C11) and fluorine-18 (F18), which are two of the most commonly used radionuclides in PET imaging. New methods include solid-phase radiochemistry, transition-metal catalyzed radiochemistry, microfluidics, click chemistry, green radiochemistry and new strategies for radiopharmaceutical quality control. These detailed monographs provide readers the necessary information needed to reproduce these synthetic reactions and new procedures in their own labs.<br /><br />Readers have key experimental details culled from the literature at their fingertips, greatly simplifying the process of qualifying a site for the clinical production of new radiopharmaceuticals.</p>

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