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List of Contributors. <p>Preface.</p> <p><b>Part 1: INTRODUCTION.</b></p> <p>1 History of Hemophilia (<i>Caroline Cromwell and Louis Aledort</i>).</p> <p>2 Hemophilia Care in the Modern World (<i>Christine A. Lee</i>).</p> <p>3 Comprehensive Care Model in Hemophilia (<i>Prasad Mathew</i>).</p> <p><b>Part 2: GENERAL TOPICS.</b></p> <p>4 When Should We Switch From On-Demand to Prophylaxis Regimen? (<i>José A. Aznar, Andres Moret, Lydia Abad-Franch, Ana Rosa Cid, Saturnino Haya and Felipe Querol</i>).</p> <p>5 Prophylaxis in Children (<i>M. Manco-Johnson</i>).</p> <p>6 Prophylaxis in Adults with Hemophilia (<i>Victor Jiménez -Yuste, Emérito-Carlos Rodríguez-Merchán, Maria-Teresa Alvarez-Román, Monica Martín –Salces</i>).</p> <p>7 The Economics of Prophylaxis: Does Prophylaxis with Clotting Factor Represent Value for Money? (<i>Alec Miners</i>).</p> <p>8 The Transition of Care for the Young Adult Hemophilia Patient (<i>Pia Petrini</i>).</p> <p>9 Perinatal Clinical Care and Molecular Diagnosis in Hemophilia (<i>Carmen Altisent and Francisco Vidal</i>).</p> <p>10 Managing the Mature Person with Hemophilia (<i>Savita Rangarajan and Thynn Thynn Yee</i>).</p> <p>11 Quality of Life in Hemophilia (<i>Eduardo Remor</i>).</p> <p><b>Part 3: INHIBITORS.</b></p> <p>12 Immunology of Inhibitor Development (<i>Birgit M Reipert, Christoph J Hofbauer, Katharina N Steinitz, Hans-Peter Schwarz, FM Horling</i>).</p> <p>13 Epidemiology of Inhibitors (<i>Johanna G. Van der Bom</i>)</p> <p>14 Early Tolerisation to Minimise Inhibitors in PUPS with Hemophilia A (<i>Günter Auerswald and Karin Kurnik</i>).</p> <p>15 Prediction of Inhibitors in Severe Hemophilia (<i>H. Marijke van den Berg and Kathelijn Fischer</i>).</p> <p>16 Genetic basis for Inhibitor Development (<i>Johannes Oldenburg and Anna Pavlova</i>).</p> <p>17 Non-Genetic Risk Factors for Inhibitor Development (<i>Lisa N. Boggio and Mindy L. Simpson</i>).</p> <p><b>Part 4: INHIBITOR TREATMENT.</b></p> <p>18 Immune Tolerance Induction Programmes (<i>Jan Blatny and Prasad Mathew</i>).</p> <p>19 Prophylaxis in Hemophilia A Patients with Inhibitors (<i>Leonard A. Valentino and Guy Young</i>).</p> <p>20 Treatment of Bleeding in FVIII Inhibitor Patients (<i>Paul Giangrande and Jerome Teitel</i>).</p> <p>21 Discordancy of By-Passing Therapy (<i>Jan Astermark</i>).</p> <p><b>Part 5: JOINT HEALTH AND DISEASE.</b></p> <p>22 Experimental Studies on Hemarthrosis, Synovitis and Arthropathy (<i>Leonard A. Valentino and Narine Hakobyan</i>).</p> <p>23 Assessment of Joint Involvement in Hemophilia (<i>Erik Berntorp</i>).</p> <p>24 Imaging of the Hemophilic Joint (<i>Carmen Martín-Hervásand Emérito-Carlos Rodríguez-Merchán</i>).</p> <p>25 Initial and Advanced Stages of Hemophilic Arthropathy, and Other Musculo-Skeletal Problems: the Role of Orthopedic Surgery (<i>Emérito-Carlos Rodríguez-Merchán, VictorJiménez -Yuste and Nicholas J. Goddard</i>).</p> <p>26 Perioperative Thromboprophylaxis for Persons with Hemophilia Undergoing Orthopaedic Surgery (<i>Gerry Dolan, Donna M. Dimichele and Emérito-Carlos Rodríguez-Merchán</i>).</p> <p><b>Part 6: NEW DEVELOPMENTS.</b></p> <p>27 New Technologies for the Pharmacokinetic Improvement of Coagulation Factor Proteins (<i>Leonard A. Valentino</i>).</p> <p>28 Current and Future Approaches to Gene Therapy in Patients with Hemophilia (<i>Maria-Teresa Alvarez- Román, Monica Martín-Salces, Victor Jiménez -Yuste and Emérito-Carlos Rodríguez-Merchán</i>).</p> <p>29 New Developments in Hemophilic Arthropathy (<i>Emérito-Carlos Rodríguez-Merchán and Leonard A. Valentino</i>).</p> <p>30 Physiotherapy Evaluation and Intervention in the Acute Hemarthrosis:  Challenging the Paradigm (<i>Nichan Zourikian and Angela L. Forsyth</i>).</p> <p>31 Laboratory Assays to Predict Response to Bypassing Agents (<i>Benny Sørensen and Claude Negrier</i>).</p> <p>32 Combination/Sequential Use of Bypassing Agents (<i>Alessandro Gringeri</i>).</p> <p>Index.</p>

<p><strong>E. C. Rodriguez-Merchan</strong>, MD, PhD, Consultant Orthopaedic Surgeon, Service of Traumatology and Orthopaedic Surgery, Haemophilia Centre, La Paz University Hospital, Madrid, Spain. <p><strong>Dr Rodriguez-Merchan</strong> is a leading orthopaedic surgeon specialising in the treatment of haemophilia. He has 127 articles on PubMed. <p><strong>Leonard A. Valentino</strong>, MD, Professor of Pediatrics; Director, Rush Hemophilia and Thrombophilia Center; Past-President, Hemophilia and Thrombosis Research Society, Rush University Medical Center, Chicago, USA.<br />Dr Valentino is a paediatrician specialising in haematology and oncology. He has 60 articles on PubMed.

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