Details

Comprehensive Enantioselective Organocatalysis


Comprehensive Enantioselective Organocatalysis

Catalysts, Reactions, and Applications, 3 Volume Set
1. Aufl.

von: Peter I. Dalko

499,00 €

Verlag: Wiley-VCH
Format: EPUB
Veröffentl.: 14.08.2013
ISBN/EAN: 9783527658886
Sprache: englisch
Anzahl Seiten: 1638

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Beschreibungen

Structured in three parts this manual recollects efficient organocatalytic transformations around clear principles that meet actual standard in asymmetric synthesis. Chapters were written by acknowledged leaders of the organocatalysis field, and are presented in a concise way. Volume 1: Privileged Catalysts gives insight to readers to the continuously increasing variety of catalysts, and the relatively complex interactions that make organocatalytic reactions selective. An appendix recollects catalyst structures with the adequate cross-references. Volume 2: Activations covers the fundamental activation types (non-covalent and covalent activations) and helps understanding the importance of physical parameters, and in particular, the role of water, that influences reactivity and selectivity. Volume 3: Reactions and Applications highlights transformations by reaction types. The final part of this volume is dedicated to application in multistep synthesis and industrial applications. Considering the ever increasing interest in the organocatalysis field, the book aims addressing to a large audience: to academic, and, industrial researchers, students and teachers who are interested in synthetic organic chemistry at advanced level. This book provides non-specialists with an introduction to the topic as well as serving as a valuable source for newcomers and researchers searching for an up-to-date and comprehensive overview of this promising area of synthetic organic chemistry.
VOLUME ONE - Privileged Catalysts PART I: AMINO ACID-DERIVED CATALYSTS Proline-Related Secondary Amine Catalysts and Applications TMS-Prolinol Catalyst in Organocatalysis Non-Proline Amino Acid Catalysts Chiral Imidazolidinone (MacMillan's Catalyst) Oligopeptides as Modular Organocatalytic Scaffolds PART II: NON-AMINO ACID-DERIVED CATALYSTS Cinchonas and Cupreidines Chiral C2 Catalysts Planar Chiral Catalysts Dynamic Approaches towards Catalyst Discovery VOLUME TWO - Activations PART I: ASYMMETRIC CATALYSIS WITH NON-COVALENT INTERACTIONS Bronsted Acids Bronsted Acids: Chiral Phosphoric Acid Catalysts in Asymmetric Synthesis Bronsted Acids: Chiral (Thio)urea Derivatives Bronsted Bases Chiral Onium Salts (Phase-Transfer Reactions) Lewis Bases Lewis Acids PART II: ASYMMETRIC CATALYSIS WITH COVALENT INTERACTIONS Rationalizing Reactivity and Selectivity in Aminocatalytic Reactions Carbene Catalysts Oxides and Epoxides Ylides PART III: TUNING CATALYST ACTIVITY AND SELECTIVITY BY THE REACTION MEDIUM AND CONDITIONS "Non-Classical" Activation of Organocatalytic Reactions (Pressure, Microwave Irradiation) Ionic Liquid Organocatalysts Polymer and Mesoporous Material Supported Organocatalysts Water in Organocatalytic Reactions VOLUME THREE - Reactions and Applications PART I: ALPHA-ALKYLATION AND HETEROATOM FUNCTIONALIZATION SN2-Type Alpha-Alkylation and Allylation Reactions Alpha-Alkylation by SN1-Type Reactions Alpha-Heteroatom Functionalization of Carbonyl Compounds PART II: NUCLEOPHILE ADDITION TO C=X BONDS Aldol and Mannich-Type Reactions Additions of Nitroalkyls and Sulfones to C=X Hydrocyanation and Strecker Reactions The Morita-Baylis-Hillman (MBH) and Hetero-MBH Reactions Reduction of C=O and C=N PART III: NUCLEOPHILE ADDITION TO C=C BONDS Addition to Alpha, Beta-Unsaturated Aldehydes and Ketones Addition to Nitroolefins and Vinyl Sulfones Organocatalyzed Asymmetric Arylation and Heteroarylation Reactions PART IV: RING-FORMING REACTIONS Intramolecular Reactions Formation of 3-, 4- and 5-Membered Cycles by Intermolecular Reactions Diels-Alder and Hetero-Diels-Alder Reactions PART V: INCREASING COMPLEXITY Organocatalytic Radical and Electron Transfer Reactions Organocatalytic Sigmatropic Reactions Regio- and Position Selective Reactions and Desymmetrizations Three or More Components Reactions (Single Catalyst Systems) Multi-Catalyst Systems Organocatalysis in Total Synthesis
Peter I. Dalko studied chemistry at the Budapest Technical University (Hungary) and graduated from Paris XI University (France) under the supervision of the late Stephan D. Gero. After undertaking postdoctoral researches with the late Sir Derek H. Barton at TAMU (USA) and Yoshito Kishi at Harvard University he is now a Research Director at the French Scientific Research Council (CNRS) at the Medical Faculty of the Sorbonne Paris Cite (France). His research is focused on total synthesis of structurally complex natural products, development of organocatalytic reactions for synthesis and developing microand nanoscale technologies for biomedical researches.
Structured in three parts this manual recollects efficient organocatalytic transformations around clear principles that meet actual standard in asymmetric synthesis. Chapters were written by acknowledged leaders of the organocatalysis field, and are presented in a concise way. Volume 1: Privileged Catalysts gives insight to readers to the continuously increasing variety of catalysts, and the relatively complex interactions that make organocatalytic reactions selective. An appendix recollects catalyst structures with the adequate cross-references. Volume 2: Activations covers the fundamental activation types (non-covalent and covalent activations) and helps understanding the importance of physical parameters, and in particular, the role of water, that influences reactivity and selectivity. Volume 3: Reactions and Applications highlights transformations by reaction types. The final part of this volume is dedicated to application in multistep synthesis and industrial applications. Considering the ever increasing interest in the organocatalysis field, the book aims addressing to a large audience: to academic, and, industrial researchers, students and teachers who are interested in synthetic organic chemistry at advanced level. This book provides non-specialists with an introduction to the topic as well as serving as a valuable source for newcomers and researchers searching for an up-to-date and comprehensive overview of this promising area of synthetic organic chemistry.

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