Details

Collaborative Computational Technologies for Biomedical Research


Collaborative Computational Technologies for Biomedical Research


Wiley Series on Technologies for the Pharmaceutical Industry, Band 10 1. Aufl.

von: Sean Ekins, Maggie A. Z. Hupcey, Antony J. Williams, Alpheus Bingham

137,99 €

Verlag: Wiley
Format: PDF
Veröffentl.: 18.04.2011
ISBN/EAN: 9781118026014
Sprache: englisch
Anzahl Seiten: 576

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Beschreibungen

<p>Methods, Processes, and Tools for Collaboration</p> <p>"The time has come to fundamentally rethink how we handle the building of knowledge in biomedical sciences today. This book describes how the computational sciences have transformed into being a key knowledge broker, able to integrate and operate across divergent data types."—Bryn Williams-Jones, Associate Research Fellow, Pfizer</p> <p>The pharmaceutical industry utilizes an extended network of partner organizations in order to discover and develop new drugs, however there is currently little guidance for managing information and resources across collaborations.</p> <p>Featuring contributions from the leading experts in a range of industries, Collaborative Computational Technologies for Biomedical Research provides information that will help organizations make critical decisions about managing partnerships, including:</p> <ul> <li> <p>Serving as a user manual for collaborations</p> </li> <li> <p>Tackling real problems from both human collaborative and data and informatics perspectives</p> </li> <li> <p>Providing case histories of biomedical collaborations and technology-specific chapters that balance technological depth with accessibility for the non-specialist reader</p> </li> </ul> <p>A must-read for anyone working in the pharmaceuticals industry or academia, this book marks a major step towards widespread collaboration facilitated by computational technologies.</p>
<b>FOREWORD xi<br /> </b><i>Alpheus Bingham</i> <p><b>PREFACE xv</b></p> <p><b>CONTRIBUTORS xix</b></p> <p><b>PART I GETTING PEOPLE TO COLLABORATE 1</b></p> <p><b>1. The Need for Collaborative Technologies in Drug Discovery 3<br /> </b><i>Chris L. Waller, Ramesh V. Durvasula, and Nick Lynch</i></p> <p><b>2. Collaborative Innovation: The Essential Foundation of Scientific Discovery 19<br /> </b><i>Robert Porter Lynch</i></p> <p><b>3. Models for Collaborations and Computational Biology 39<br /> </b><i>Shawnmarie Mayrand-Chung, Gabriela Cohen-Freue, and Zsuzsanna Hollander</i></p> <p><b>4. Precompetitive Collaborations in the Pharmaceutical Industry 55<br /> </b><i>Jackie Hunter</i></p> <p><b>5. Collaborations in Chemistry 85<br /> </b><i>Sean Ekins, Antony J. Williams, and Christina K. Pikas</i></p> <p><b>6. Consistent Patterns in Large-Scale Collaboration 99<br /> </b><i>Robin W. Spencer</i></p> <p><b>7. Collaborations Between Chemists and Biologists 113<br /> </b><i>Victor J. Hruby</i></p> <p><b>8. Ethics of Collaboration 121<br /> </b><i>Richard J. McGowan, Matthew K. McGowan, and Garrett J. McGowan</i></p> <p><b>9. Intellectual Property Aspects of Collaboration 133<br /> </b><i>John Wilbanks</i></p> <p><b>PART II METHODS AND PROCESSES FOR COLLABORATIONS 147</b></p> <p><b>10. Scientific Networking and Collaborations 149<br /> </b><i>Edward D. Zanders</i></p> <p><b>11. Cancer Commons: Biomedicine in the Internet Age 161<br /> </b><i>Jeff Shrager, Jay M. Tenenbaum, and Michael Travers</i></p> <p><b>12. Collaborative Development of Large-Scale Biomedical Ontologies 179<br /> </b><i>Tania Tudorache and Mark A. Musen</i></p> <p><b>13. Standards for Collaborative Computational Technologies for Biomedical Research 201<br /> </b><i>Sean Ekins, Antony J. Williams, and Maggie A. Z. Hupcey</i></p> <p><b>14. Collaborative Systems Biology: Open Source, Open Data, and Cloud Computing 209<br /> </b><i>Brian Pratt</i></p> <p><b>15. Eight Years Using Grids for Life Sciences 221<br /> </b><i>Vincent Breton, Lydia Maigne, David Sarramia, and David Hill</i></p> <p><b>16. Enabling Precompetitive Translational Research: A Case Study 241<br /> </b><i>Sándor Szalma</i></p> <p><b>17. Collaboration in Cancer Research Community: Cancer Biomedical Informatics Grid (caBIG) 261<br /> </b><i>George A. Komatsoulis</i></p> <p><b>18. Leveraging Information Technology for Collaboration in Clinical Trials 281<br /> </b><i>O. K. Baek</i></p> <p><b>PART III TOOLS FOR COLLABORATIONS 301</b></p> <p><b>19. Evolution of Electronic Laboratory Notebooks 303<br /> </b><i>Keith T. Taylor</i></p> <p><b>20. Collaborative Tools to Accelerate Neglected Disease Research: Open Source Drug Discovery Model 321<br /> </b><i>Anshu Bhardwaj, Vinod Scaria, Zakir Thomas, Santhosh Adayikkoth, Open Source Drug Discovery (OSDD) Consortium, and Samir K. Brahmachari</i></p> <p><b>21. Pioneering Use of the Cloud for Development of Collaborative Drug Discovery (CDD) Database 335<br /> </b><i>Sean Ekins, Moses M. Hohman, and Barry A. Bunin</i></p> <p><b>22. Chemspider: a Platform for Crowdsourced Collaboration to Curate Data Derived From Public Compound Databases 363<br /> </b><i>Antony J. Williams</i></p> <p><b>23. Collaborative-Based Bioinformatics Applications 387<br /> </b><i>Brian D. Halligan</i></p> <p><b>24. Collaborative Cheminformatics Applications 399<br /> </b><i>Rajarshi Guha, Ola Spjuth, and Egon Willighagen</i></p> <p><b>PART IV THE FUTURE OF COLLABORATIONS 423</b></p> <p><b>25. Collaboration Using Open Notebook Science in Academia 425<br /> </b><i>Jean-Claude Bradley, Andrew S. I. D. Lang, Steve Koch, and Cameron Neylon</i></p> <p><b>26. Collaboration and the Semantic Web 453<br /> </b><i>Christine Chichester and Barend Mons</i></p> <p><b>27. Collaborative Visual Analytics Environment for Imaging Genetics 467<br /> </b><i>Zhiyu He, Kevin Ponto, and Falko Kuester</i></p> <p><b>28. Current and Future Challenges for Collaborative Computational Technologies for the Life Sciences 491<br /> </b><i>Antony J. Williams, Renée J. G. Arnold, Cameron Neylon, Robin W. Spencer, Stephan Schürer, and Sean Ekins</i></p> <p>INDEX 519</p>
"The book is of interest to researchers developing IT systems in the pharmaceutical industry, and for those participating in drug discovery collaborations." (Book News, 1 October 2011) <p>"What unveiled itself as I turned the pages was ... a truthful, meaningful accounting of an evolving social science, perhaps a hope that the pure thrill of crowdsourcing may accelerate the process of discovery while preserving a free market economy.... The book contains... [contributions from a] multi-national task force if you will of some of the world's finest minds in life and physical science and ‘cloud-native' knowledge-sharing." (Untangled Health, 11 August 2011)</p> <p> </p>
<b>SEAN EKINS, MSc, PhD, DSc</b>, is the Principal at Collaborations in Chemistry, and Collaborations Director at Collaborative Drug Discovery, Inc., as well as an Adjunct Associate Professor in the Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy. He has published more than 170 papers and book chapters on computational and in vitro drug discovery approaches and has previously edited or co-edited three books for Wiley. <p><b>MAGGIE A. Z. HUPCEY, PhD,</b> is a chemist working within the Life Sciences and Healthcare Practice of PA Consulting Group in Princeton, New Jersey. She has worked on collaborative projects for the design and development of new products and processes in the medical device, drug delivery, and drug discovery fields, including presubmission and post-launch regulatory compliance activities.</p> <p><b>ANTONY J. WILLIAMS, PhD, FRSC</b>, is currently Vice President, Strategic Development, at the Royal Society of Chemistry and holds an adjunct position at UNC-Chapel Hill. He has written chapters for many books and published more than 100 peer-reviewed papers and book chapters on NMR, predictive ADME methods, Internet-based tools, crowdsourcing, and database curation. He is an active blogger and participant in the Internet chemistry network.</p>
<p>Methods, Processes, and Tools for Collaboration</p> <p>"The time has come to fundamentally rethink how we handle the building of knowledge in biomedical sciences today. This book describes how the computational sciences have transformed into being a key knowledge broker, able to integrate and operate across divergent data types."—Bryn Williams-Jones, Associate Research Fellow, Pfizer</p> <p>The pharmaceutical industry utilizes an extended network of partner organizations in order to discover and develop new drugs, however there is currently little guidance for managing information and resources across collaborations.</p> <p>Featuring contributions from the leading experts in a range of industries, Collaborative Computational Technologies for Biomedical Research provides information that will help organizations make critical decisions about managing partnerships, including:</p> <ul> <li> <p>Serving as a user manual for collaborations</p> </li> <li> <p>Tackling real problems from both human collaborative and data and informatics perspectives</p> </li> <li> <p>Providing case histories of biomedical collaborations and technology-specific chapters that balance technological depth with accessibility for the non-specialist reader</p> </li> </ul> <p>A must-read for anyone working in the pharmaceuticals industry or academia, this book marks a major step towards widespread collaboration facilitated by computational technologies.</p>

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