Clinical Radiation OncologyIndications, Techniques, and Results
This fully updated and enhanced third edition offers a highly practical, application-based review of the biological basis of radiation oncology and the clinical efficacy of radiation therapy. Revised edition of the classic reference in radiation oncology from Dr. C.C. Wang, whose practical approach to clinical application was legendary Includes the latest developments in the field: intensity modulated radiation therapy (IMRT), image guided radiation therapy, and particle beam therapy Includes two brand new chapters Palliative Radiotherapy, and Statistics in Radiation Oncology Features a vibrant and extremely comprehensive head and neck section Provides immediately applicable treatment algorithms for each tumor
Dedication ix Preface xi Contributors xiii Section 1 Scientific Foundations 1Section Editor:William Small Jr. 1 Basic Concepts of Clinical Radiation Oncology 3Hannah Yoon, Karan Shah,William Small Jr,Minesh P.Mehta and John P. Hayes 2 Radiation Biology for Radiation Oncologists 15Timothy A. Chan, Boris Hristov and Simon N. Powell 3 Treatment Planning 62George T.Y. Chen and Jong H. Kung 4 Image-Guided Radiation Therapy 83Monique Youl, Kristy K. Brock and Laura A. Dawson 5 A Guide to Understanding Statistics in Radiation Oncology 99Kathryn Winter 6 Use of Protons for Radiation Therapy 115Mark Pankuch, Nasiruddin Mohammed, Draik Hecksel, Steve Laub, Sean Boyer and William F. Hartsell 7 Principles of Palliative Radiation Therapy 141Randy L. Wei, Bo A. Wan, Edward Chowand Stephen Lutz 8 Patient Safety and Quality: Management for the Radiation Oncologist 158Fiori Alite and Abhishek A. Solanki Section 2 Cancers of the Head and Neck 175Section Editor: Min Yao 9 Carcinoma of the Oral Cavity 177Keith Unger, Felix Ho, James Melotek and Nancy Lee 10 Oropharyngeal Cancer 202Charles Woods, Mitchell Machtay and Min Yao 11 Larynx and Hypopharynx 227Changhu Chen 12 Carcinoma of the Nasopharynx 248Keith Unger, Felix Ho, James Melotek and Nancy Lee 13 Carcinoma of the Paranasal Sinuses and Nasal Cavity 269Farzan Siddiqui, Nicholas Galanopoulos and Min Yao 14 Salivary Gland Carcinomas 288Allen M. Chen 15 Cervical Nodes with Unknown Primary Carcinomas 300Min Yao, Pierre Lavertu and Mitchell Machtay 16 Temporal Bone Tumors 313Allen M. Chen 17 Thyroid Cancer 318Roi Dagan and Robert J. Amdur 18 Head and Neck Radiation Therapy Sequelae and Late Complications and the Role of IMRT 335Xiaoshen Wang and Avraham Eisbruch Section 3 Cancer of the Intrathorax 349Section Editor: Minesh P. Mehta 19 Lung Cancer 351Deepak Khuntia, Pranshu Mohindra and Minesh P. Mehta 20 Carcinoma of the Esophagus 385Grace J. Kim and Mohan Suntharalingam Section 4 Gastrointestinal Malignancies 397Section Editor: Christopher G.Willett 21 Gastric Cancer 399Joanna Y. Chin and Theodore S. Hong 22 Pancreatic Cancer 409Manisha Palta, Christopher G.Willett and Brian G. Czito 23 Colon Cancer 429Jennifer Y. Wo 24 Rectal Cancer 438Jennifer Y. Wo 25 Anal Cancer 466Brian G. Czito, Manisha Palta and Christopher G. Willett Section 5 Genitourinary Malignancies 481Section Editor: Jason A. Efstathiou 26 Bladder Cancer 483Phillip J. Gray,William U. Shipley and Jason A. Efstathiou 27 Prostate Cancer 497Abhishek A. Solanki, Rebecca I. Hartman, Phillip J. Gray, Brent S. Rose, Jonathan J. Paly, Kent W. Mouw and Jason A. Efstathiou 28 Carcinoma of the Upper Urinary Tract 531Anthony L. Zietman, Jonathan J. Paly and Jason A. Efstathiou 29 Testicular Cancer 539Jonathan J. Paly and Jason A. Efstathiou 30 Penile Cancer 549Kent W. Mouw, Anthony L. Zietman and Jason A. Efstathiou Section 6 Gynecological Malignancies 557Section Editor:William Small Jr. 31 Endometrium 559Ann Klopp and Patricia Eifel 32 Vulva 576Kanokpis Townamchai, Caitlin Newhouse and Akila N. Viswanathan 33 Ovary 597Charles A. Kunos 34 Vagina 618Charles A. Kunos 35 Cervix 631Charles A. Kunos Section 7 Miscellaneous Sites 673Section Editor:William Small, Jr 36 Cancer of the Skin 675Justin Lee, Elizabeth Barnes, May Tsao and Phillip Devlin 37 Cancer of the Breast 694Jonathan B. Strauss, Monica Morrow and William Small Jr 38 Soft-Tissue Sarcomas 739Jonathan B. Ashman and Kaled M. Alektiar 39 Tumors of the Central Nervous System 757Phillip J. Gray, Jay S. Loeffler and Helen A. Shih 40 The Lymphomas 775Caitlin Costello, Loren K. Mell and Parag Sanghvi 41 Pediatric Tumors 805Shannon M. MacDonald, Torunn I. Yock, Nancy J. Tarbell and Tamara Z. Vern-Gross Index 845
William Small Jr, MD, Professor of Radiation Oncology, Professor and Chair of the Department of Radiation Oncology, Loyola University Chicago Stritch School of Medicine, Chicago, IL, USA Associate Editors Nancy J. Tarbell, MD, Dean for Academic and Clinical Affairs and the C.C. Wang Professor of Radiation Oncology, Harvard Medical School, MA, USA Min Yao, MD, PhD, Department of Radiation Oncology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA Section Editors Minesh Mehta, MD, Jason A. Efstathiou, MD, and Chis Willet, MD Dr Chiu-Chen Wang, Founding Editor of Clinical Radiation Oncology Edited for two successful editions (1988 and 2000) by the eminent physician Dr Chiu-Chen Wang, this book was designed to offer highly practical, application-based comprehensive overview of the biological basis of radiation oncology and the clinical efficacy of radiation therapy. Dr Wang, widely known as "C.C." and well known for his "???skilled and no-nonsense methods of dealing with the various types of major organ cancers," passed away in 2005. He was a highly acclaimed leader in the field of radiation oncology based at Harvard Medical School, which established the "C.C. Wang Professorship in Radiation Oncology."
This fully updated and enhanced Third Edition offers a highly practical, application-based review of the biological basis of radiation oncology and the clinical efficacy of radiation therapy. Building on the legacy of Dr C.C. Wang, this new edition has been edited by Dr William Small Jr, and written by a team of outstanding, international oncologic expert contributors. It provides a comprehensive resource delivering concise, well-planned chapters offering a thorough review of the different solid organ tumors and radiation therapy technique. Chapters discuss disease by anatomic site covering relevant background information on each tumor, including epidemiology, pathology, diagnostic work-up, prognostic factors, treatment techniques, applications of surgery and chemotherapy, end results of treatment, and pertinent clinical trials. The comprehensive and rigorous assessment of each tumor site provides the foundation for the proper application of radiation therapy technique equipping the radiation oncologist with a "gold standard" approach. This edition: Includes the latest developments in the field; intensity-modulated radiation therapy (IMRT), image-guided radiation therapy, and particle beam therapy Includes two new chapters: Palliative Radiotherapy, and Statistics in Radiation Oncology Features a vibrant and extremely comprehensive head and neck section Provides immediately applicable treatment algorithms Is extensively illustrated with over 250 photographs, drawings, and diagrams As in the first two editions, the Third Edition of Clinical Radiation Oncology features contributions from renowned international specialists who have worked in a close collaboration to provide focused, clinically relevant information in a concise, user-friendly format ideal for the radiation oncologist, oncologic surgeon, medical oncologist, oncology nurse, radiation therapist, and resident.
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