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<p>Preface vii</p> <p><b>Part 1 Introduction 1</b></p> <p>1 Introduction to endocrinology 2</p> <p><b>Part 2 Disorders of the hypothalamic–pituitary axis 5</b></p> <p>2 The hypothalamic–pituitary axis and its assessment 6</p> <p>3 Acromegaly 8</p> <p>4 Cushing’s syndrome 10</p> <p>5 Hypopituitarism and non-functioning pituitary adenomas 12</p> <p>6 Prolactinoma and hyperprolactinaemia 14</p> <p><b>Part 3 Disorders of thirst and fluid balance 17</b></p> <p>7 Hypernatraemia and diabetes insipidus 18</p> <p>8 Hyponatraemia and SIADH 20</p> <p><b>Part 4 Thyroid disorders 23</b></p> <p>9 Thyroid function 24</p> <p>10 Hyperthyroidism: clinical presentation and investigation 26</p> <p>11 Hyperthyroidism: management and ophthalmopathy 28</p> <p>12 Hyperthyroidism: special circumstances 30</p> <p>13 Hypothyroidism 32</p> <p>14 Goitre, thyroid nodules and cancer 34</p> <p><b>Part 5 Disorders of calcium homeostasis 37</b></p> <p>15 Physiology of calcium, PTH and vitamin D metabolism 38</p> <p>16 Hypercalcaemia 40</p> <p>17 Hypocalcaemia 42</p> <p>18 Osteoporosis 44</p> <p><b>Part 6 Disorders of the adrenal gland 47</b></p> <p>19 Steroid physiology and biochemical assessment 48</p> <p>20 Adrenal insufficiency 50</p> <p>21 Adrenocortical tumours 52</p> <p>22 Disorders of the adrenal medulla 54</p> <p><b>Part 7 Disorders of the reproductive system 57</b></p> <p>23 Physiology of the reproductive system 58</p> <p>24 Growth, puberty and sexual differentiation 60</p> <p>25 Menstrual disturbance 62</p> <p>26 Hyperandrogenism 64</p> <p>27 Menopause and HRT 66</p> <p>28 Male hypogonadism 68</p> <p>29 Gynaecomastia 70</p> <p>30 Infertility 72</p> <p><b>Part 8 Neuroendocrine tumours 75</b></p> <p>31 Neuroendocrine tumours 76</p> <p>32 Neuroendocrine tumours: management 78</p> <p>33 Inherited endocrine tumour syndromes 80</p> <p>34 Spontaneous hypoglycaemia 82</p> <p><b>Part 9 Endocrine emergencies 85</b></p> <p>35 Adrenal crisis 86</p> <p>36 Pituitary apoplexy 88</p> <p>37 Myxoedema coma 90</p> <p>38 Thyroid storm 92</p> <p>39 Acute hyponatraemia 94</p> <p>40 Severe hypercalcaemia 96</p> <p>41 Acute hypocalcaemia 98</p> <p><b>Part 10 Diabetes mellitus 101</b></p> <p>42 Overview 102</p> <p>43 Diagnosis and monitoring 104</p> <p>44 Classification 106</p> <p>45 Type 1 diabetes: aetiology and clinical presentation 108</p> <p>46 Type 1 diabetes: insulin and other therapies 110</p> <p>47 Type 2 diabetes: aetiology and clinical presentation 112</p> <p>48 Type 2 diabetes: treatment 114</p> <p>49 Macrovascular complications 116</p> <p>50 Microvascular complications 118</p> <p>51 Diabetic foot disease 120</p> <p>52 Diabetic ketoacidosis 122</p> <p>53 Hyperglycaemic hyperosmolar state 124</p> <p>54 Hypoglycaemia 126</p> <p>55 Peri-operative management 128</p> <p>56 Management of acute illness 131</p> <p>57 Insulin infusions 134</p> <p>58 Pregnancy and diabetes 136</p> <p>59 Genetics of diabetes 138</p> <p>60 The multidisciplinary team 140</p> <p>61 Lipid disorders 142</p> <p>62 Appetite and weight 144</p> <p>63 Obesity and anorexia 146</p> <p>Index 148</p>

<p>Dr Aled Rees, Consultant Endocrinologist, School of Medicine, Cardiff University</p> <p>Dr Miles Levy, Consultant Endocrinologist, University Hospitals of Leicester</p> <p>Dr Andrew Lansdown, Consultant Endocrinologist, University Hospital of Wales, Cardiff</p>

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