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List of Contributors vii <p>Foreword xi</p> <p>Preface xii</p> <p><b>Part I Pathology, Indications, and Review of Clinical Trials</b></p> <p>1 The pathobiology of CTO 3<br /> <i>Sergey Yalonetsky, Azriel B. Osherov & Bradley H. Strauss</i></p> <p>2 Collateral circulation in CTO 9<br /> <i>Alfredo R. Galassi, S.D. Tomasello & Hazem Khamis</i></p> <p>3 CTO: review of trials 18<br /> <i>Tina L. Pinto Slottow & Ron Waksman</i></p> <p>4 CTO-percutaneous coronary intervention: what is the evidence? 26<br /> <i>Gabriel Maluenda, Tina L. Pinto Slottow & Ron Waksman</i></p> <p>5 Case selection and long-term benefits 33<br /> <i>Imran N. Ahmad, Kamran I. Muhammad & Patrick L. Whitlow</i></p> <p><b>Part II Imaging</b></p> <p>6 CT angiography: application in chronic total occlusions 45<br /> <i>Hidehiko Hara, John R. Lesser, Nicholas Burke & Robert S. Schwartz</i></p> <p>7 Co-registration CTO and CT angiography 51<br /> <i>Gary M. Idelchik & Ariel Roguin</i></p> <p>8 Optical coherence tomography to guide the treatment of chronic total occlusions 60<br /> <i>Nicola Viceconte, Rodrigo Teijeiro-Mestre, Nicolas Foin, Alistair C. Lindsay and Carlo Di Mario.</i></p> <p>9 IVUS-guided CTO-PCI 67<br /> <i>Masashi Kimura & Yasushi Asakura</i></p> <p>10 IVUS evaluation of CTO 78<br /> <i>Akiko Maehara, Masahiko Ochiai & Gary S. Mintz</i></p> <p>11 Magnetic navigation wire 85<br /> <i>Steve Ramcharitar & Patrick Serruys</i></p> <p><b>Part III Wires Technology</b></p> <p>12 Deflecting wire systems 93<br /> <i>Mirko Schiemann</i></p> <p>13 Asahi wires 97<br /> <i>Shigeru Saito</i></p> <p>14 IVUS-guided recanalization of CTO 105<br /> <i>Etsuo Tsuchikane</i></p> <p>15 Frontrunner CTO technology 109<br /> <i>Chad Kliger, Steven P. Sedlis & Jeffrey D. Lorin</i></p> <p>16 Channel dilator: Corsair 113<br /> <i>Masashi Kimura</i></p> <p><b>Part IV Wires Technique</b></p> <p>17 Tornus catheter 121<br /> <i>Hideaki Kaneda</i></p> <p>18 Antegrade approach: step by step 126<br /> <i>Nicolaus Reifart</i></p> <p>19 Use of two wires in the treatment of CTO 134<br /> <i>Yves Louvard, Thierry Lefèvre & Marie-Claude Morice</i></p> <p>20 Parallel-wire techniques 143<br /> <i>Sudhir Rathore & Takahiko Suzuki</i></p> <p>21 Guidewire handling techniques for CTO lesions 147<br /> <i>Shigeru Saito</i></p> <p>22 Subintimal angioplasty in coronary CTO 155<br /> <i>Philippe Généreux & George D. Dangas</i></p> <p>23 Antegrade device assisted re-entry techniques 162<br /> <i>Nicolaus Reifart</i></p> <p>24 The microchannel technique 166<br /> <i>Mauro Carlino, Gill L. Buchanan & Cosmo Godino</i></p> <p>25 The STAR technique 172<br /> <i>Cosmo Godino, Mauro Carlino & Antonio Colombo</i></p> <p>26 Attempting CTO after first failed attempt 178<br /> <i>Sudhir Rathore & Takahiko Suzuki</i></p> <p>27 Transradial approach for CTO lesions and tapered-tip guidewires 184<br /> <i>Shigeru Saito</i></p> <p>28 Bilateral approach 191<br /> <i>Osamu Katoh</i></p> <p>29 Tips and tricks of the CART technique 198<br /> <i>Osamu Katoh</i></p> <p><b>Part V Devices Technology</b></p> <p>30 Recanalizing total occlusion in the periphery: utilization of radio frequency and other technology 209<br /> <i>Shishir Murarka & Richard Heuser</i></p> <p>31 High-frequency mechanical revascularization 226<br /> <i>Eberhard Grube & Lutz Buellesfeld</i></p> <p>32 Debulking of CTO 230<br /> <i>Etsuo Tsuchikane</i></p> <p>33 Vibrational angioplasty 235<br /> <i>Lampros K. Michalis</i></p> <p>34 Treatment of chronic total coronary occlusions with drug-eluting stents: overview of angiographic and clinical outcomes 240<br /> <i>David E. Kandzari</i></p> <p>35 Laser for CTO recanalization 251<br /> <i>On Topaz</i></p> <p>36 The ENABLER-P: a novel CTO crossing cystem 257<br /> <i>Maurice Buchbinder</i></p> <p>37 Collagenase plaque digestion for facilitating guidewire crossing 262<br /> <i>Azriel B. Osherov & Bradley H. Strauss</i></p> <p>38 The BridgePoint re-entry system 268<br /> <i>Imran N. Ahmad, Kamran I. Muhammad & Patrick L. Whitlow</i></p> <p><b>Part VI Complications</b></p> <p>39 Complications during the retrograde approach for CTO 275<br /> <i>Shigeru Saito</i></p> <p>40 CTO: how to minimize contrast nephropathy 279<br /> <i>Travis J. Bench & Luis Gruberg</i></p> <p><b>Part VII Interesting Cases</b></p> <p>41 Interesting cases I–VI 291<br /> <i>Shigeru Saito</i></p> <p>Index 301</p>

<p>“This is a very helpful book for those interested in invasive treatment of CTOs.  The authors provide practical explanations, supplemented by detailed imaging and pragmatic discussions of the latest advances in their treatment.”  (<i>Doody’s</i>, 4 October 2013)</p>

<p>Edited by<br /><b>Ron Waksman,</b> MD, FACC<br />Division of Cardiology, MedStar Washington Hospital Center, Washington, DC, USA</p> <p><b>Shigeru Saito</b>, MD, FACC, FSCAI, FJCC<br />Cardiology & Catheterization Laboratories, Shonan Kamakura General Hospital, Kamakura, Japan</p>

<p>“Chronic total occlusions continue to represent one of the greatest challenges to interventional cardiologists.”<br /> <b>Cardiovascular Research Foundation</b></p> <p><b>Chronic total occlusions (CTOs) can be found in 30% of patients with coronary artery disease</b><br /> Despite advances, CTOs remain one of the most frequently identified lesions in interventional cardiology<br /> yet least likely to be successfully treated. The prevalence of the disorder is vexing. The threat to your patients is significant. The condition is complex. And, treatment remains a challenge.</p> <p><b>Learn from internationally-recognized physician-educators how to approach CTOs</b> Turn to <i>Chronic Total Occlusions: A Guide to Recanalization, Second Edition</i> for expert insight into the world of CTOs and clear, practical guidance you can apply directly and immediately in your cath lab.</p> <p>Offering the most comprehensive information available, this completely updated second edition provides<br /> you with:</p> <p>• Full-color images from the diagnostic modalities that are essential in identifying CTOs</p> <p>• Data on indications and efficacy from the most recent clinical trials</p> <p>• Practical guidance on the selection and use of the latest wires and devices</p> <p>• Even more tips and tricks from leading operators from the world’s busiest centers</p> <p>• Clinical cases to illustrate some of the more complex scenarios and common complications</p> <p>• And more!</p> <p><i>Chronic Total Occlusions: A Guide to Recanalization, Second Edition</i> is the guide you can count on to<br /> improve the CTO success rate at your facility. Order your copy today!</p>

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