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Cellular Basis of Morphogenesis


Cellular Basis of Morphogenesis


Novartis Foundation Symposia, Band 144 1. Aufl.

von: David Evered, Joan Marsh

121,99 €

Verlag: Wiley
Format: PDF
Veröffentl.: 30.04.2008
ISBN/EAN: 9780470513804
Sprache: englisch
Anzahl Seiten: 316

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Beschreibungen

Contributors to this symposium focus on the interface between genes and cells, covering genetic analysis, cloning studies, and the investigation of cell lineages and cellular interactions. They note how the body axes are already determined in the eggs of invertebrates and amphibia, then consider the mechanisms as the egg cleaves, in annelids, arthropods, amphibia, and mice that underlie assignation of cells to specific lineages, which give rise to different tissues in the adult. Closing chapters characterize the molecules that mediate each cell's particular fate, its position in the final body plan as the result of cell sorting or, in some cases, cell migration.
Partial table of contents: <p>The Cellular Interphase (A. Garcia-Bellido).</p> <p>Localization of mRNA and Axis Formation During <i>Xenopus</i> Embryogenesis (D. Melton, <i>et al.</i>).</p> <p>Morphogen Gradients and the Control of Body Pattern in Insect Embryos (G. Struhl).</p> <p>The Establishment of Regional Identity in the <i>Xenopus</i> Blastula (J. Heasman, <i>et al.</i>).</p> <p>Factors Specifying Cell Lineages in the Leech (D. Weisblat & S. Astrow).</p> <p><i>n Vivo</i> Competition Identifies Positive <i>Cis</i>-Regulatory Elements Required for Lineage-Specific Gene Expression in the Sea Urchin Embryo (R. Franks, <i>et al.</i>).</p> <p>Cell Allocation and Lineage in the Early Mouse Embryo (R. Gardner).</p> <p>Induction and Organization of the Body Plan in <i>Xenopus</i> Development (J. Cooke).</p> <p>Structure and Function of the Bithorax Complex Genes of <i>Drosophila</i> (A. Busturia, <i>et al.</i>).</p> <p>Cadherin-Mediated Specific Cell Adhesion and Animal Morphogenesis (M. Takeichi, <i>et al.</i>).</p> <p>Polarity and Patterning in the Neural Tube: The Origin and Function of the Floor Plate (T. Jessell, <i>et al.</i>).</p> <p>Cellular Communication in the Developing <i>Drosophila</i> Eye (A. Tomlinson).</p> <p>Index of Contributors.</p> <p>Subject Index.</p>
<p><b>David Evered</b> and <b>Joan Marsh</b> are the editors of <i>Cellular Basis of Morphogenesis</i> and other titles.</p>
Cellular Basis of Morphogenesis Chairman: L. Wolpert 1989 The establishment of body pattern in developing embryos has been studied since early this century. Descriptive accounts have been superseded by systematic screening for mutants, identification of the genes involved and isolation of these genes; firstly in organisms such as Drosophila where genetic techniques are well established, more recently in mammals using transfection and insertional mutagenesis. This book focuses on the interface between genes and cells, covering genetic analysis, cloning studies, and the investigation of cell lineages and cellular interactions. The opening chapters describe how the body axes are already determined in the eggs of invertebrates and amphibia. In all species, as the egg cleaves, cells are assigned to specific lineages, which give rise to different tissues in the adult. The mechanisms underlying these processes in annelids, arthropods, amphibia and mice are discussed. After a cell has adopted a particular fate, its position in the final body plan is the result of cell sorting and, in some cases, cell migration. The final chapters cover the characterization of the molecules that mediate these activities. Related Ciba Foundation Symposia: No 138 Plasticity of the neuromuscular system Chairman: A. J. Buller 1988 ISBN 0 471 91902 0 No 145 Carbohydrate recognition in cellular function Chairman: E. Ruoslahti 1989 ISBN 0 471 92307 9 (in press)

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