Cancer ConsultExpertise for Clinical Practice
The field of oncology benefits from several large-scale reference books and a host of monographs dedicated to specific cancers. However, truly excellent practice and review books are, surprisingly, quite scarce. Outside of a scant handful of books and online reference tools that offer clinical response practice and board review in a basic question and answer format, there are no resources that offer a robust, engaging, fully referenced tool for these vital activities in every oncologist’s and oncology trainee’s work. This print and electronic book seeks to fill that void, offering comprehensive question-and-answer style content that covers the entire specialty of oncology and provides practicing oncologists with a fascinating and immediately applicable compendium of vital information dealing with a well-balanced selection of common and uncommon cancers. At the heart of this book is the editor’s and authors’ desire to overcome the controversies and barriers to practice that usually emerge following the appearance of new data. In every section, the user is guided toward collaboration in ongoing clinical research – for example, via discussions of well-designed ongoing clinical trials in each specific area. Developed with both the teacher and learner in mind, this book also offers trainees and fellows an excellent opportunity to enhance their preparation for the ABIM oncology fellowship exam as well as for the oncology boards. It will also be an extremely useful tool for oncologists working toward the recertification exam. This comprehensive, beefy book includes hundreds of painstakingly developed multiple-choice and mini-case-based questions covering the principles of medical oncology, malignant hematology, surgical oncology, and radiation oncology. It also contains mini-cases and questions dealing with the biology, diagnosis, classification, staging, and multidisciplinary treatment of cancers at every anatomic site. The very latest topics are included, such as molecular techniques, targeted therapies, and translational cancer research. Concise but detailed answers are referenced to key journals and books, and evidence-based wherever possible. NCCN guidelines are also referenced as appropriate. With its powerful focus on take-home messages from and for actual clinical work, this book will help keep oncologists up to date, bridging the gaps between journal and reference literature, conferences, and their existing knowledge base.
List of Contributors, x Preface, xxi Section 1 Malignant Hematology and Hematopoietic Cell Transplantation Part 1 Acute Lymphoblastic Leukemia in Adults 1 Diagnosis of acute lymphoblastic leukemia, 5 Frederick G. Behm, Agatha Bogard, Syed A. Abutalib, and Sujata S. Gaitonde 2 Prognostic markers and models in acute lymphoblastic leukemia, 18 Dieter Hoelzer 3 Management of B-cell acute lymphoblastic leukemia, 22 Hady Ghanem, Hagop Kantarjian, Nitin Jain, and Elias Jabbour 4 Management of T-cell acute lymphoblastic leukemia, 29 Daniel J. DeAngelo 5 Minimal residual disease in acute lymphoblastic leukemia, 35 Meir Wetzler 6 Hematopoietic cell transplantation in adult acute lymphoblastic leukemia, 40 Netanel A. Horowitz and Jacob M. Rowe Part 2 Acute Myeloid Leukemia in Adults 7 Prognosis in acute myeloid leukemia: cytogenetics and beyond, 51 Gordana Raca, Madina Sukhanova, and Lucy A. Godley 8 Induction therapy in acute myeloid leukemia, 58 Tapan Kadia and Farhad Ravandi 9 Consolidation therapy in acute myeloid leukemia, 67 Gregory K. Behbehani and Bruno C. Medeiros 10 Management of acute promyelocytic leukemia, 71 Eytan M. Stein and Martin S. Tallman 11 Minimal residual disease in acute myeloid leukemia, 76 Hans Beier Ommen, Line Nederby, Marie Toft-Petersen, Charlotte Guldborg Nyvold, and Peter Hokland 12 Relapsed and refractory acute myeloid leukemia, 82 Stefan H. Faderl 13 Hematopoietic cell transplantation in acute myeloid leukemia, 89 Antonio M. Jimenez and Stefan O. Ciurea Part 3 Myelodysplastic Syndromes and Related Disorders 14 Pitfalls in the diagnosis of myelodysplastic syndromes, 99 Jay Yang, Gail Bentley, and Charles A. Schiffer 15 Cytogenetics and prognostic models in myelodysplastic syndromes, 106 Uma Borate and Harry P. Erba 16 Management of myelodysplastic syndromes, 113 Vu H. Duong, Alan F. List, and Rami S. Komrokji 17 Management of therapy-related myeloid neoplasms, 120 Jagoda K. Jasielec and Richard A. Larson 18 Hematopoietic cell transplantation in myelodysplastic syndromes, 126 Antonio Di Stasi, Armin Ghobadi, and Partow Kebriaei 19 Acquired aplastic anemia, 131 Valeria Visconte and Ramon V. Tiu Part 4 Myeloproliferative Neoplasms 20 Diagnostic approach in myeloproliferative neoplasms, 137 Ayalew Tefferi 21 Chronic myeloid leukemia: chronic phase, 142 Jerald P. Radich 22 Blast crisis of chronic myeloid leukemia, 147 Michael J. Mauro 23 Chronic myeloid leukemia and pregnancy, 150 Michael J. Mauro 24 Polycythemia vera, 152 Constantine S. Tam and Srdan Verstovsek 25 Essential thrombocytosis, 156 Paola Guglielmelli and Alessandro M. Vannucchi 26 Primary myelofibrosis, 162 Ayalew Tefferi 27 Eosinophilic myeloproliferative disorders, 167 Jason Gotlib 28 Chronic myelomonocytic leukemia, 176 Mrinal M. Patnaik 29 Hematopoietic cell transplantation in chronic myeloid leukemia, 180 Jerald P. Radich 30 Hematopoietic cell transplantation in primary myelofibrosis, 187 Irum Khan and Damiano Rondelli Part 5 Chronic Lymphocytic and Other Leukemias 31 Prognostic markers and management of chronic lymphocytic leukemia, 195 Courtney D. DiNardo and Susan O’Brien 32 Hematopoietic cell transplantation in chronic lymphocytic leukemia, 201 Michael R. Bishop 33 Prolymphocytic leukemia, 207 Claire Dearden 34 Hairy cell leukemia, 220 Justin M. Watts and Martin S. Tallman Part 6 Hodgkin Lymphoma 35 Management of classical Hodgkin lymphoma, 229 Kristen Sanfi lippo and Nancy L. Bartlett 36 Nodular lymphocyte-predominant Hodgkin lymphoma, 235 Dennis A. Eichenauer 37 Hematopoietic cell transplantation in Hodgkin lymphoma, 240 Tsiporah Shore and Koen van Besien Part 7 Non-Hodgkin’s Lymphomas 38 Pitfalls in the diagnosis of non-Hodgkin’s lymphomas, 247 Carmen Barcena and Laurence de Leval 39 Follicular lymphoma, 257 Myron S. Czuczman 40 Diffuse large B-cell lymphoma, 263 Andrew D. Zelenetz 41 Mantle cell lymphoma, 270 Stephen Smith and John Sweetenham 42 Marginal zone lymphoma, 275 Sarah Rutherford, Wayne Tam, and Peter Martin 43 Primary mediastinal large B-cell lymphoma, 282 Pier Luigi Zinzani 44 Burkitt lymphoma, 286 Mark Roschewski and Wyndham Wilson 45 Gray zone lymphoma, 290 Caron A. Jacobson and Ann S. LaCasce 46 Transformed lymphoma, 295 Stephane Doucet and Jane N. Winter 47 HIV-associated lymphoma, 304 Kieron Dunleavy 48 Primary CNS lymphoma, 308 Nicholas A. Blondin, Joachim M. Baehring, and Fred H. Hochberg 49 Primary cutaneous lymphoma, 316 Thomas M. Habermann 50 Mycosis fungoides and Sézary syndrome, 323 Stephane Dalle, Marie Perier-Muzet, Brigitte Balme, and Luc Thomas 51 Hematopoietic cell transplantation in indolent non-Hodgkin’s lymphoma, 327 Saurabh Chhabra and Ginna G. Laport 52 Hematopoietic cell transplantation in diffuse large B-cell lymphoma, 332 Syed A. Abutalib and Istvan Redei 53 Hematopoietic cell transplantation in T-cell non-Hodgkin’s lymphomas, 339 Lori S. Muffly and Sonali M. Smith Part 8 Plasma Cell Neoplasms and Related Disorders 54 Smoldering multiple myeloma and monoclonal gammopathy of undetermined significance, 347 Robert A. Kyle 55 Risk stratification and response assessment in multiple myeloma and Waldenström’s macroglobulinemia, 352 Silvia Gentili and Sagar Lonial 56 Treatment of multiple myeloma, 358 Cindy Varga, Claudia Paba Prada, Kenneth Anderson, and Paul Richardson 57 Light-chain amyloidosis, 366 David C. Seldin 58 Waldenström’s macroglobulinemia, 371 Anita D’Souza and Morie A. Gertz 59 Autologous hematopoietic cell transplantation in multiple myeloma, 376 Jean-Luc Harousseau and Mohamad Mohty 60 Allogeneic hematopoietic cell transplantation in multiple myeloma, 381 Jasleen Randhawa, Veerpal Singh, and Parameswaran Hari Part 9 Special Issues in Hematology 61 Role of PET scan in lymphomas, 391 Matthew A. Lunning and James O. Armitage 62 Radioimmunotherapy in lymphomas, 398 Reem Karmali and Stephanie A. Gregory 63 Radiation oncology consultation for hematologic malignancies, 403 Chris R. Kelsey and Leonard R. Prosnitz Part 10 Special Issues in Hematopoietic Cell Transplantation 64 Donor and graft selection in allogeneic hematopoietic cell transplantation, 411 Jose Leonel Ochoa-Bayona and Claudio Anasetti 65 Preparative regimens in allogeneic hematopoietic cell transplantation for malignant hematological diseases, 417 Robert J. Soiffer 66 T-cell depletion in allogeneic hematopoietic cell transplantation, 421 Jenna D. Goldberg and Miguel-Angel Perales 67 Prevention and treatment of relapse following hematopoietic cell transplantation, 426 Robert Chen, Sandra Thomas, and Stephen J. Forman 68 Acute graft-versus-host disease, 432 Andrew C. Harris and John E. Levine 69 Chronic graft-versus-host disease, 438 Carrie L. Kitko and Daniel R. Couriel Section 2 Oncology Part 1 Central Nervous System Tumors 70 Primary brain tumors, 449 Barbara J. O’Brien and Mark R. Gilbert 71 Secondary brain and spinal cord tumors, 457 Rimas V. Lukas, Patrik Gabikian, and Steven J. Chmura Part 2 Head and Neck Cancers and Thoracic Malignancies 72 Medical management of head and neck cancers, 467 Tobenna Nwizu and David Adelstein 73 Endocrine malignancies, 476 Ann W. Gramza 74 Methodological and practical challenges for personalized therapies in non-small-cell lung cancer, 480 Ignacio I. Wistuba 75 Screening, staging, and stage I non-small-cell lung cancer, 486 Tarek M. Mekhail 76 Stage II and III non-small-cell lung cancer, 493 Grzegorz Korpanty and Natasha B. Leighl 77 Recurrent and metastatic non-small-cell lung cancer and novel targets, 500 Evan Pisick and Ravi Salgia 78 Small-cell lung cancer, 503 Stephen V. Liu and Glen J. Weiss 79 Mesothelioma, 506 Christopher W. Towe and Harvey I. Pass Part 3 Breast Cancer 80 Immunohistochemistry testing and beyond in breast cancer, 515 Alejandro A. Gru and D. Craig Allred 81 Prevention and adjuvant therapy in breast cancer, 523 Faithlore P. Gardner and Edith A. Perez 82 Preoperative systemic therapy for breast cancer, 532 Virginia Kaklamani and William J. Gradishar 83 Recurrent and metastatic breast cancer, 540 Dennis L. Citrin 84 Special issues in the young and pregnant patient with breast cancer, 546 Hatem A. Azim Jr. and Fedro A. Peccatori Part 4 Gastrointestinal Oncology 85 Early-stage esophageal and stomach cancers, 555 M. Naomi Horiba and Yixing Jiang 86 Metastatic esophagogastric cancer: controversies, consensus, and new targets, 562 Geoffrey Y. Ku and David H. Ilson 87 Early-stage colorectal cancer, 567 Vaibhav Sahai and Al B. Benson III 88 Recurrent and metastatic colorectal cancer: controversies, consensus, and new targets, 573 Davendra Sohal and Robert J. Pelley 89 Pancreatic cancer, 581 Katherine Van Loon and Margaret Tempero 90 Hepatobiliary cancer, 590 Keith Stuart 91 Neuroendocrine tumors, 595 Anya Litvak and Leonard Saltz 92 Transarterial liver-directed therapies in oncology, 601 Divyesh G. Mehta and Jeffery Choh 93 Anal cancer, 606 Rob Glynne Jones Part 5 Genitourinary Oncology 94 Renal cancer: tumor diversity, molecular taxonomy, and prognostic algorithms, 615 Henry J. Conter and Eric Jonasch 95 Medical management of renal cancer, 621 Gary R. MacVicar and Timothy M. Kuzel 96 Medical management of bladder cancer, 628 Gary R. MacVicar and Timothy M. Kuzel 97 Prostate cancer: Screening, surveillance, prognostic algorithms and independent pathologic predictive parameters, 634 Megan G. Lockyer and Thomas M. Wheeler 98 Medical management of prostate cancer, 638 Elizabeth K. O’Donnell and Philip Kantoff 99 Germ cell tumors, 645 Timothy Gilligan Part 6 Skin Malignancies 100 Medical management of melanoma, 653 Ana M. Ciurea and Kim Margolin 101 Nonmelanoma skin cancers, 661 Daniel Christiansen and Anna Sancho Clayton PART 7 Gynecological Malignancies 102 Ovarian cancer: neoadjuvant, adjuvant, and surgical issues, 669 Alpa M. Nick and Robert L. Coleman 103 Ovarian cancer: second-line treatment strategies, 675 Maurie Markman 104 Endometrial and cervical cancers, 681 Maurie Markman PART 8 Sarcomas 105 Bone sarcomas, 689 Nicole Larrier, William C. Eward, and Richard F. Riedel 106 Soft tissue sarcomas, 696 Neeta Somaiah and Shreyaskumar Patel PART 9 Multidisciplinary Approach: Consultation with Surgical Oncology Team 107 Surgical aspects of head and neck cancers, 707 Constance E.H. Teo and Randal S. Weber 108 Surgical aspects of thoracic malignancies, 711 Albert S.Y. Chang, Thomas A. D’Amico, and David C. White 109 Surgical aspects of upper gastrointestinal cancers, 719 Sabha Ganai and Mitchell C. Posner 110 Surgical aspects of pancreatic cancer, 723 Amanda B. Cooper, Ching-Wei D. Tzeng, and Matthew H.G. Katz 111 Surgical aspects of hepatobiliary tumors, 729 Subhasis Misra and Leonidas Koniaris 112 Surgical aspects of lower gastrointestinal cancers, 735 Anthony J. Senagore 113 Surgical aspects of renal cancer, 739 Michael E. Woods and Matthew C. Raynor 114 Surgical aspects of bladder cancer, 744 Michael B. Williams 115 Surgical aspects of prostate cancer, 747 Peter Pinto 116 Surgical aspects of melanoma, 754 Thomas Velancia PART 10 Multidisciplinary Approach: Consultation with Radiation Oncology Team 117 Radiotherapy for head and neck cancers, 761 Shiyu Song 118 Radiotherapy for ductal carcinoma in situ (DCIS), 767 Beryl McCormick 119 Radiotherapy for early-stage invasive breast cancer, 771 Julia White 120 Radiotherapy for thoracic malignancies, 778 Meredith E. Giuliani and Andrea Bezjak 121 Radiotherapy for gastrointestinal malignancies, 785 Manisha Palta, Christopher Willett, and Brian Czito 122 Radiotherapy for genitourinary malignancies, 789 Christina H. Chapman and Curtiland Deville PART 11 Hereditary Cancer Syndromes and Genetic Testing in Oncology 123 When to suspect hereditary cancer syndromes, 795 Emily Dalton and Kathy Schneider 124 Hereditary breast cancer syndromes, 800 Kathy Schneider and Emily Dalton 125 Genetic testing in gastrointestinal tumors, 804 Kristen M. Shannon and Daniel C. Chung 126 Hereditary urogenital cancer syndromes, 810 Melanie Corbman and Eric Fowler PART 12 Special Issues in Hematology and Oncology 127 Carcinoma of unknown primary (CUP), 817 Isabella C. Glitza and Gauri R. Varadhachary 128 Geriatric oncology, 822 Nayana Kamath and Supriya Gupta Mohile 129 Nuts and bolts of cancer immunotherapy, 826 Christopher R. Heery and James L. Gulley 130 Controversies related to oncology clinical trial development, 831 Elihu H. Estey 131 PET scan in oncology, 835 Shaunagh McDermott and Michael A. Blake 132 Hematopoietic growth factors, 841 LeAnn B. Norris, Jametta Magwood, and Charles L. Bennett 133 Anticoagulation issues in oncology, 844 Steven M. Corsello and Jean Marie Connors 134 Symptom management and palliative care, 851 Rony Dev and Eduardo D. Bruera 135 Metabolic and nutritional issues in oncology, 860 Julia Fechtner, Carolyn Lammersfeld, Carol Ireton-Jones, and Pankaj Vashi 136 Bone-related issues in oncology, 867 S. Mujtaba Rizvi, Helen Collins, and Alan Lipton 137 Integrative medicine in oncology, 872 Weidong Lu and David S. Rosenthal 138 Naturopathic medicine in oncology, 879 Christina M. Shannon, Tracey Thomas, and Shauna Birdsall 139 Anesthesiology consultation for localized cancer pain, 884 Abed Rahman, Magdalena Anitescu, and Raed Rahman 140 Musculoskeletal care in oncology, 893 James E. Rosenberg and Charles A. McDonald 141 Cancer survivorship and psychosocial issues in oncology, 896 Jabeen Abutalib, Shahid Raza, and Laura Sunn Index, 902 Color plate section facing p.522
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