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<p><b>Part I Analyzing DNA, RNA, and Protein Sequences</b></p> <p>1 Introduction 3</p> <p>2 Access to Sequence Data and Related Information 19</p> <p>3 Pairwise Sequence Alignment 69</p> <p>4 Basic Local Alignment Search Tool (BLAST) 121</p> <p>5 Advanced Database Searching 167</p> <p>6 Multiple Sequence Alignment 205</p> <p>7 Molecular Phylogeny and Evolution 245</p> <p><b>Part II Genomewide Analysis of DNA, RNA, and Protein</b></p> <p>8 DNA: The Eukaryotic Chromosome 307</p> <p>9 Analysis of Next-Generation Sequence Data 377</p> <p>10 Bioinformatic Approaches to Ribonucleic Acid (RNA) 433</p> <p>11 Gene Expression: Microarray and RNA-seq Data Analysis 479</p> <p>12 Protein Analysis and Proteomics 539</p> <p>13 Protein Structure 589</p> <p>14 Functional Genomics 635</p> <p><b>Part III Genome Analysis</b></p> <p>15 Genomes Across the Tree of Life 699</p> <p>16 Completed Genomes: Viruses 755</p> <p>17 Completed Genomes: Bacteria and Archaea 797</p> <p>18 Eukaryotic Genomes: Fungi 847</p> <p>19 Eukaryotic Genomes: From Parasites to Primates 887</p> <p>20 Human Genome 957</p> <p>21 Human Disease 1011</p> <p>Glossary 1075</p> <p>Self-Test Quiz: Solutions 1103</p> <p>Author Index 1105</p> <p>Subject Index 1109</p>

<p><b>Jonathan Pevsner</b>, PhD, is a Professor in the Department of Neurology at Kennedy Krieger Institute, an internationally recognized institution dedicated to improving the lives of children with neurodevelopmental disorders. He holds a primary faculty appointment as Professor in the Department of Psychiatry and Behavioral Sciences (Johns Hopkins University School of Medicine). He holds joint or secondary appointments in the Department of Neuroscience, the Institute of Genetic Medicine, and the Division of Health Sciences Informatics (Johns Hopkins School of Medicine), and the Department of Molecular Microbiology and Immunology (Johns Hopkins Bloomberg School of Public Health). He has taught bioinformatics courses since 2000 at the Johns Hopkins School of Medicine, and was awarded Teacher of the Year honors by the Graduate Student Association in both 2001 and 2006, the Professors' Award for Excellence in Teaching awarded by the medical faculty (2003), Teacher of the Year (Advanced Academic Programs, 2009), and Teaching Excellence Award in the Johns Hopkins Bloomberg School of Public Health (2011). In 2013 his lab used whole genome sequencing and reported a mutation that causes a rare disease, Sturge-Weber syndrome, as well as a commonly occurring port-wine stain birthmark.</p>

<p><b>The bestselling introduction to bioinformatics and genomics – now in its <i>third edition</i></b></p> <p>Widely received in its previous editions, <i>Bioinformatics and Functional Genomics</i> offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go-to source for students and professionals involved in biomedical research.</p> <p>This book provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:</p> <ul> <li>Extensive revisions and a slight reorder of chapters for a more effective organization</li> <li>A brand new chapter on next-generation sequencing</li> <li>An expanded companion website, also updated as and when new information becomes available</li> <li>Greater emphasis on a computational approach, with clear guidance of how software tools work and introductions to the use of command-line tools such as software for next-generation sequence analysis, the R programming language, and NCBI search utilities</li> </ul> <p>The book is complemented by lavish illustrations and more than 500 figures and tables - many newly-created for the third edition to enhance clarity and understanding. Each chapter includes learning objectives, a problem set, pitfalls section, boxes explaining key techniques and mathematics/statistics principles, a summary, recommended reading, and a list of freely available software. Readers may visit a related Web page for supplemental information such as PowerPoints and audiovisual files of lectures, and videocasts of how to perform many basic operations: www.wiley.com/go/pevsnerbioinformatics.</p> <p><i>Bioinformatics and Functional Genomics, Third Edition </i>serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.</p>

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